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- W2922349654 abstract "Intracellular lipid accumulation has been associated with a poor prognosis in cancer. We have previously reported the involvement of lipid droplets in cell proliferation in colon cancer cells, suggesting a role for these organelles in cancer development. In this study, we evaluate the role of lipid droplets in cell cycle regulation and cellular transformation. Cell cycle synchronization of NIH 3T3 cells revealed increased numbers and dispersed distribution of lipid droplets specifically during S phase. Also, the transformed cell lineage NIH 3T3-H-rasV12 showed an accumulation of both lipid droplets and PLIN2 protein above the levels in NIH 3T3 cells. PLIN2 gene overexpression, however, was not able to induce NIH 3T3 cell transformation, disproving the hypothesis that PLIN2 is an oncogene. Furthermore, positive PLIN2 staining was strongly associated with highly proliferative Ki-67-positive areas in human colon adenocarcinoma tissue samples. Taken together, these results indicate that cell cycle progression is associated with tight regulation of lipid droplets, a process that is altered in transformed cells, suggesting the existence of a mechanism that connects cell cycle progression and cell proliferation with lipid accumulation." @default.
- W2922349654 created "2019-03-22" @default.
- W2922349654 creator A5002244856 @default.
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- W2922349654 creator A5056957225 @default.
- W2922349654 date "2019-05-01" @default.
- W2922349654 modified "2023-10-17" @default.
- W2922349654 title "Cell Cycle Progression Regulates Biogenesis and Cellular Localization of Lipid Droplets" @default.
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- W2922349654 doi "https://doi.org/10.1128/mcb.00374-18" @default.
- W2922349654 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6469922" @default.
- W2922349654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30782775" @default.
- W2922349654 hasPublicationYear "2019" @default.
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