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• W2922349975 abstract "Hypertension is a prevalent, complex and polygenic cardiovascular disease, which is associated with increased mortality and morbidity. Across the world, traditional Chinese medicine (TCM) constituted by herbal medicine and non-pharmacological therapies is used to assist blood pressure management. Though widely accepted in daily practice, its mechanism remains largely unknown. Recent years saw a number of studies utilizing metabolomics technologies to elucidate the biological foundation of the antihypertensive effect of TCM. Metabolomics is a relatively ‘young’ omics approach that has gained enormous attention recently in cardiovascular drug discovery and pharmacology studies of natural products. In this review, we described the use of metabolomics in deciphering TCM diagnostic codes for hypertension and in revealing molecular events that drive the antihypertensive effect. By corroborating the diagnostic rules, there’s accumulating evidence showing that metabolic profile could be the signature of different syndromes/patterns of hypertension, which offers new perspectives for disease diagnosis and efficacy optimization. Moreover, TCM treatment significantly altered the metabolic perturbations associated with hypertension, which could be a crucial mechanism of the therapeutic effect of TCM. Not only significantly rebalances the dynamics of metabolic flux, TCM but also elicits metabolic network reorganization through restoring the functions of key metabolites, and metabolic pathways. The role of TCM in regulating metabolic perturbations will be informative to researchers seeking new leads for drug discovery. This review further envisioned the promises of employing metabolomics to explore network pharmacology, host-gut microbiota interactions and metabolic reprogramming in TCM, and possible herb-drug interactions in this field in future." @default.
• W2922349975 created "2019-03-22" @default.
• W2922349975 creator A5015198590 @default.
• W2922349975 creator A5018295627 @default.
• W2922349975 date "2019-03-08" @default.
• W2922349975 modified "2023-09-30" @default.
• W2922349975 title "Emerging Applications of Metabolomics in Traditional Chinese Medicine Treating Hypertension: Biomarkers, Pathways and More" @default.
• W2922349975 cites W132196007 @default.
• W2922349975 cites W1518190589 @default.
• W2922349975 cites W1549912426 @default.
• W2922349975 cites W1596479267 @default.
• W2922349975 cites W1597273370 @default.
• W2922349975 cites W1693752077 @default.
• W2922349975 cites W1797956629 @default.
• W2922349975 cites W1966322986 @default.
• W2922349975 cites W1970709685 @default.
• W2922349975 cites W1970930529 @default.
• W2922349975 cites W1973231143 @default.
• W2922349975 cites W1973829843 @default.
• W2922349975 cites W1980799772 @default.
• W2922349975 cites W1981149380 @default.
• W2922349975 cites W1982852364 @default.
• W2922349975 cites W1983624870 @default.
• W2922349975 cites W1986129954 @default.
• W2922349975 cites W1990058257 @default.
• W2922349975 cites W1993628165 @default.
• W2922349975 cites W1993957210 @default.
• W2922349975 cites W1994863439 @default.
• W2922349975 cites W1997062226 @default.
• W2922349975 cites W1998533429 @default.
• W2922349975 cites W2001903432 @default.
• W2922349975 cites W2004452745 @default.
• W2922349975 cites W2010847239 @default.
• W2922349975 cites W2014864482 @default.
• W2922349975 cites W2016187822 @default.
• W2922349975 cites W2016418843 @default.
• W2922349975 cites W2037370235 @default.
• W2922349975 cites W2041628570 @default.
• W2922349975 cites W2042439240 @default.
• W2922349975 cites W2042445733 @default.
• W2922349975 cites W2042952308 @default.
• W2922349975 cites W2046396835 @default.
• W2922349975 cites W2048533654 @default.
• W2922349975 cites W2054885423 @default.
• W2922349975 cites W2061156796 @default.
• W2922349975 cites W2061464639 @default.
• W2922349975 cites W2066846767 @default.
• W2922349975 cites W2074299694 @default.
• W2922349975 cites W2076515304 @default.
• W2922349975 cites W2079790205 @default.
• W2922349975 cites W2080184611 @default.
• W2922349975 cites W2082714887 @default.
• W2922349975 cites W2085036690 @default.
• W2922349975 cites W2087129770 @default.
• W2922349975 cites W2087492315 @default.
• W2922349975 cites W2087865072 @default.
• W2922349975 cites W2088980248 @default.
• W2922349975 cites W2093657255 @default.
• W2922349975 cites W2095465112 @default.
• W2922349975 cites W2097498614 @default.
• W2922349975 cites W2102709588 @default.
• W2922349975 cites W2102794013 @default.
• W2922349975 cites W2111256272 @default.
• W2922349975 cites W2116114989 @default.
• W2922349975 cites W2123683638 @default.
• W2922349975 cites W213096282 @default.
• W2922349975 cites W2131186249 @default.
• W2922349975 cites W2133669558 @default.
• W2922349975 cites W2135170450 @default.
• W2922349975 cites W2138385561 @default.
• W2922349975 cites W2140041517 @default.
• W2922349975 cites W2141058448 @default.
• W2922349975 cites W2141986536 @default.
• W2922349975 cites W2142856784 @default.
• W2922349975 cites W2142885994 @default.
• W2922349975 cites W2148473209 @default.
• W2922349975 cites W2155680682 @default.
• W2922349975 cites W2157562956 @default.
• W2922349975 cites W2158355556 @default.
• W2922349975 cites W2161902274 @default.
• W2922349975 cites W2163949090 @default.
• W2922349975 cites W2165926971 @default.
• W2922349975 cites W2168047024 @default.
• W2922349975 cites W2171078840 @default.
• W2922349975 cites W2171322355 @default.
• W2922349975 cites W2236927123 @default.
• W2922349975 cites W2295182096 @default.
• W2922349975 cites W2324986020 @default.
• W2922349975 cites W2352521542 @default.
• W2922349975 cites W2400332190 @default.
• W2922349975 cites W2401629805 @default.
• W2922349975 cites W2415998686 @default.
• W2922349975 cites W2416211062 @default.
• W2922349975 cites W2513580483 @default.
• W2922349975 cites W2522093042 @default.
• W2922349975 cites W2529503249 @default.
• W2922349975 cites W2536987917 @default.
• W2922349975 cites W2560340862 @default.
• W2922349975 cites W2560835389 @default.
• W2922349975 cites W2567160193 @default.

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