Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922356585> ?p ?o ?g. }
- W2922356585 endingPage "59" @default.
- W2922356585 startingPage "50" @default.
- W2922356585 abstract "Dyslipidemia is an important risk factor for cardiovascular diseases. Fucoidan (FUC) is a polysaccharide extracted from brown marine algae with various biological activities. Galactooligosaccharides (GOS) are important prebiotics that exert benefits on the intestinal microbiota. The aim of this study was to investigate the effects of FUC and GOS on dyslipidemia in rats by modulating the gut microbiota and bile acid metabolism.Twenty-four male inbred Sprague-Dawley (SD) rats aged 8 wk were fed a normal or high-fat diet (HFD) for 8 wk. During the feeding period, rats were gavaged with normal saline solution, FUC solution (100 mg/kg),or GOS solution (800 mg/kg), or a combination of both once daily. Serum biochemical parameters were determined, and the gut microbiota were analyzed via 16S rRNA gene sequencing. Bile salt hydrolase (BSH) activity in the small intestinal contents was also analyzed. The effects of FUC and GOS on Lactobacillus casei DM8121 were analyzed in vitro.In rats, GOS and FUC supplementation significantly improved serum total cholesterol, low-density lipoprotein cholesterol, lipopolysaccharide, serum total bile acid, hepatic tissue steatosis, aortic arch injury, gut microbiota, serum high-density lipoprotein cholesterol, cholesterol 7-alpha hydroxylase expression in the liver, and BSH activity in the small intestinal contents. In an in vitro experiment, GOS and FUC supplementation significantly increased L. casei DM8121's BSH activity.In rats, FUC and GOS supplementation improved serum dyslipidemia, gut microbiota, BSH activity, and bile acid metabolism-related pathways. In vitro, GOS and FUC supplementation increased L. casei DM8121's BSH activity." @default.
- W2922356585 created "2019-03-22" @default.
- W2922356585 creator A5005974424 @default.
- W2922356585 creator A5017353282 @default.
- W2922356585 creator A5026828904 @default.
- W2922356585 creator A5048755096 @default.
- W2922356585 creator A5060013340 @default.
- W2922356585 creator A5071687930 @default.
- W2922356585 creator A5076222782 @default.
- W2922356585 creator A5077866259 @default.
- W2922356585 date "2019-09-01" @default.
- W2922356585 modified "2023-10-01" @default.
- W2922356585 title "Fucoidan and galactooligosaccharides ameliorate high-fat diet–induced dyslipidemia in rats by modulating the gut microbiota and bile acid metabolism" @default.
- W2922356585 cites W1524169968 @default.
- W2922356585 cites W1790787093 @default.
- W2922356585 cites W1966311917 @default.
- W2922356585 cites W1976818997 @default.
- W2922356585 cites W1980914602 @default.
- W2922356585 cites W1981504305 @default.
- W2922356585 cites W1982914684 @default.
- W2922356585 cites W1986647484 @default.
- W2922356585 cites W199262836 @default.
- W2922356585 cites W1995393174 @default.
- W2922356585 cites W2018213438 @default.
- W2922356585 cites W2020916024 @default.
- W2922356585 cites W2033048555 @default.
- W2922356585 cites W2035779227 @default.
- W2922356585 cites W2036771282 @default.
- W2922356585 cites W2041255015 @default.
- W2922356585 cites W2047556994 @default.
- W2922356585 cites W2048971537 @default.
- W2922356585 cites W2056253073 @default.
- W2922356585 cites W2073332363 @default.
- W2922356585 cites W2077574170 @default.
- W2922356585 cites W2084960042 @default.
- W2922356585 cites W2085175109 @default.
- W2922356585 cites W2087577664 @default.
- W2922356585 cites W2103970981 @default.
- W2922356585 cites W2112940932 @default.
- W2922356585 cites W2120009957 @default.
- W2922356585 cites W2122277908 @default.
- W2922356585 cites W2125826054 @default.
- W2922356585 cites W2127505063 @default.
- W2922356585 cites W2133964299 @default.
- W2922356585 cites W2134897177 @default.
- W2922356585 cites W2138411980 @default.
- W2922356585 cites W2138546203 @default.
- W2922356585 cites W2145232186 @default.
- W2922356585 cites W2147203117 @default.
- W2922356585 cites W2147726663 @default.
- W2922356585 cites W2148305363 @default.
- W2922356585 cites W2149573313 @default.
- W2922356585 cites W2161129780 @default.
- W2922356585 cites W2167084464 @default.
- W2922356585 cites W2170886805 @default.
- W2922356585 cites W2200285648 @default.
- W2922356585 cites W2280231561 @default.
- W2922356585 cites W2281941613 @default.
- W2922356585 cites W2294177598 @default.
- W2922356585 cites W2324161694 @default.
- W2922356585 cites W2332492464 @default.
- W2922356585 cites W2396003270 @default.
- W2922356585 cites W2469343084 @default.
- W2922356585 cites W2549568832 @default.
- W2922356585 cites W2552283579 @default.
- W2922356585 cites W2584092516 @default.
- W2922356585 cites W2604894279 @default.
- W2922356585 cites W2626300127 @default.
- W2922356585 cites W2763122985 @default.
- W2922356585 cites W2783754831 @default.
- W2922356585 cites W2808975724 @default.
- W2922356585 cites W2884119528 @default.
- W2922356585 cites W80087853 @default.
- W2922356585 doi "https://doi.org/10.1016/j.nut.2019.03.001" @default.
- W2922356585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31029922" @default.
- W2922356585 hasPublicationYear "2019" @default.
- W2922356585 type Work @default.
- W2922356585 sameAs 2922356585 @default.
- W2922356585 citedByCount "93" @default.
- W2922356585 countsByYear W29223565852019 @default.
- W2922356585 countsByYear W29223565852020 @default.
- W2922356585 countsByYear W29223565852021 @default.
- W2922356585 countsByYear W29223565852022 @default.
- W2922356585 countsByYear W29223565852023 @default.
- W2922356585 crossrefType "journal-article" @default.
- W2922356585 hasAuthorship W2922356585A5005974424 @default.
- W2922356585 hasAuthorship W2922356585A5017353282 @default.
- W2922356585 hasAuthorship W2922356585A5026828904 @default.
- W2922356585 hasAuthorship W2922356585A5048755096 @default.
- W2922356585 hasAuthorship W2922356585A5060013340 @default.
- W2922356585 hasAuthorship W2922356585A5071687930 @default.
- W2922356585 hasAuthorship W2922356585A5076222782 @default.
- W2922356585 hasAuthorship W2922356585A5077866259 @default.
- W2922356585 hasConcept C100544194 @default.
- W2922356585 hasConcept C100817775 @default.
- W2922356585 hasConcept C126322002 @default.
- W2922356585 hasConcept C134018914 @default.
- W2922356585 hasConcept C2775909754 @default.