Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922356756> ?p ?o ?g. }
- W2922356756 abstract "SUMMARY Better understanding the progression of neural stem cells (NSCs) in the developing cerebral cortex is important for modeling neurogenesis and defining the pathogenesis of neuropsychiatric disorders. Here we used RNA-sequencing, cell imaging and lineage tracing of mouse and human in vitro NSCs to model the generation of cortical neuronal fates. We show that conserved signaling mechanisms regulate the acute transition from proliferative NSCs to committed glutamatergic excitatory neurons. As human telencephalic NSCs developed from pluripotency in vitro , they first transitioned through organizer states that spatially pattern the cortex before generating glutamatergic precursor fates. NSCs derived from multiple human pluripotent lines varied in these early patterning states leading differentially to dorsal or ventral telencephalic fates. This work furthers systematic analysis of the earliest patterning events that generate the major neuronal trajectories of the human telencephalon." @default.
- W2922356756 created "2019-03-22" @default.
- W2922356756 creator A5011268118 @default.
- W2922356756 creator A5013182443 @default.
- W2922356756 creator A5014965298 @default.
- W2922356756 creator A5025704103 @default.
- W2922356756 creator A5026311709 @default.
- W2922356756 creator A5026436089 @default.
- W2922356756 creator A5027701541 @default.
- W2922356756 creator A5029112284 @default.
- W2922356756 creator A5033103731 @default.
- W2922356756 creator A5038455977 @default.
- W2922356756 creator A5040039946 @default.
- W2922356756 creator A5042585311 @default.
- W2922356756 creator A5043264677 @default.
- W2922356756 creator A5044440275 @default.
- W2922356756 creator A5055872472 @default.
- W2922356756 creator A5056121164 @default.
- W2922356756 creator A5058677167 @default.
- W2922356756 creator A5060071592 @default.
- W2922356756 creator A5066530681 @default.
- W2922356756 creator A5069366529 @default.
- W2922356756 creator A5080758121 @default.
- W2922356756 creator A5086282462 @default.
- W2922356756 date "2019-03-15" @default.
- W2922356756 modified "2023-10-13" @default.
- W2922356756 title "Variation of human neural stem cells generating organizer states in vitro before committing to cortical excitatory or inhibitory neuronal fates" @default.
- W2922356756 cites W1485371658 @default.
- W2922356756 cites W1493073807 @default.
- W2922356756 cites W1503727145 @default.
- W2922356756 cites W1564357553 @default.
- W2922356756 cites W1603868355 @default.
- W2922356756 cites W1768523798 @default.
- W2922356756 cites W1964137734 @default.
- W2922356756 cites W1966955323 @default.
- W2922356756 cites W1967611229 @default.
- W2922356756 cites W1967679856 @default.
- W2922356756 cites W1967946279 @default.
- W2922356756 cites W1970783808 @default.
- W2922356756 cites W1971559485 @default.
- W2922356756 cites W1972968697 @default.
- W2922356756 cites W1974651731 @default.
- W2922356756 cites W1979952856 @default.
- W2922356756 cites W1980607613 @default.
- W2922356756 cites W1981164058 @default.
- W2922356756 cites W1982780398 @default.
- W2922356756 cites W1982946814 @default.
- W2922356756 cites W1990935914 @default.
- W2922356756 cites W1991949401 @default.
- W2922356756 cites W1993965691 @default.
- W2922356756 cites W1999225599 @default.
- W2922356756 cites W2003835684 @default.
- W2922356756 cites W2007034511 @default.
- W2922356756 cites W2007187950 @default.
- W2922356756 cites W2009742334 @default.
- W2922356756 cites W2011526626 @default.
- W2922356756 cites W2020539766 @default.
- W2922356756 cites W2021707007 @default.
- W2922356756 cites W2022335405 @default.
- W2922356756 cites W2022976940 @default.
- W2922356756 cites W2023652080 @default.
- W2922356756 cites W2025260963 @default.
- W2922356756 cites W2027246053 @default.
- W2922356756 cites W2028776222 @default.
- W2922356756 cites W2039600900 @default.
- W2922356756 cites W2044142173 @default.
- W2922356756 cites W2063478423 @default.
- W2922356756 cites W2066015597 @default.
- W2922356756 cites W2071596650 @default.
- W2922356756 cites W2071598557 @default.
- W2922356756 cites W2078950435 @default.
- W2922356756 cites W2083495710 @default.
- W2922356756 cites W2087786585 @default.
- W2922356756 cites W2089993812 @default.
- W2922356756 cites W2094038606 @default.
- W2922356756 cites W2100007797 @default.
- W2922356756 cites W2100086434 @default.
- W2922356756 cites W2101502746 @default.
- W2922356756 cites W2102793585 @default.
- W2922356756 cites W2104793567 @default.
- W2922356756 cites W2106461017 @default.
- W2922356756 cites W2109630386 @default.
- W2922356756 cites W2110387447 @default.
- W2922356756 cites W2112074923 @default.
- W2922356756 cites W2117317524 @default.
- W2922356756 cites W2117677048 @default.
- W2922356756 cites W2118712914 @default.
- W2922356756 cites W2119608950 @default.
- W2922356756 cites W2120761216 @default.
- W2922356756 cites W2120815463 @default.
- W2922356756 cites W2123252501 @default.
- W2922356756 cites W2124134886 @default.
- W2922356756 cites W2129261595 @default.
- W2922356756 cites W2130793535 @default.
- W2922356756 cites W2132649118 @default.
- W2922356756 cites W2135835495 @default.
- W2922356756 cites W2136101247 @default.
- W2922356756 cites W2139646621 @default.
- W2922356756 cites W2139808477 @default.
- W2922356756 cites W2143981060 @default.