FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922363098> ?p ?o ?g. }

• W2922363098 endingPage "4089" @default.
• W2922363098 startingPage "4083" @default.
• W2922363098 abstract "Background: Inflammation is a condition that jeopardizes the continuity of pregnancy because it increases the secretion of chemokines that favor the migration of leukocytes from maternal and fetal circulations to the cervix, placenta, and the chorioamniotic membranes. During pregnancy, the level of prolactin (PRL) in the amniotic fluid is high; there is evidence to suggest that PRL contributes to maintain a privileged immune environment in the amniotic cavity. We test the effect of prolactin on the secretion profile of chemokines in human fetal membranes.Methods: Nine fetal membranes collected from healthy nonlabouring cesarean deliveries at term. We placed whole membrane explants in a two-chamber culture system. Choriodecidua and amniotic chambers were pretreated with 250, 500, 1000, or 4000 ng/ml of PRL for 24 h, then choriodecidua was cotreated with 500 ng/ml of lipopolysaccharide (LPS) and PRL for 24 h. We used ELISA to measure secreted levels of four chemokines (RANTES, monocyte chemoattractant protein 1 (MCP-1), MIP-1α, and IL-8) in both amnion and choriodecidua regions.Results: In comparison with basal conditions, LPS treatment induced significantly higher secretion of RANTES, MCP-1, and MIP-1α, but not of IL-8. RANTES was mainly produced by choriodecidua and cotreatment with PRL significantly decreased its LPS-induced secretion. MCP-1 was primarily produced by the amnion and its secretion was only inhibited by 4000 ng/ml of PRL. Both membrane regions produced MIP-1α, which was significantly inhibited at 1000 and 4000 ng/ml PRL concentrations. IL-8 showed no significant changes regardless of PRL concentration.Conclusion: PRL inhibits the differential secretion of proinflammatory chemokines by human fetal membranes." @default.
• W2922363098 created "2019-03-22" @default.
• W2922363098 creator A5008842025 @default.
• W2922363098 creator A5033749351 @default.
• W2922363098 creator A5034206051 @default.
• W2922363098 creator A5051059039 @default.
• W2922363098 creator A5062504168 @default.
• W2922363098 creator A5062790055 @default.
• W2922363098 creator A5066822950 @default.
• W2922363098 creator A5067268445 @default.
• W2922363098 creator A5070951144 @default.
• W2922363098 creator A5073924079 @default.
• W2922363098 creator A5087977009 @default.
• W2922363098 creator A5088297202 @default.
• W2922363098 date "2019-03-27" @default.
• W2922363098 modified "2023-10-17" @default.
• W2922363098 title "Prolactin selectively inhibits the LPS-induced chemokine secretion of human foetal membranes" @default.
• W2922363098 cites W1830630019 @default.
• W2922363098 cites W1893553316 @default.
• W2922363098 cites W1963777456 @default.
• W2922363098 cites W1965539209 @default.
• W2922363098 cites W1973023139 @default.
• W2922363098 cites W1976852176 @default.
• W2922363098 cites W1986611953 @default.
• W2922363098 cites W1990063572 @default.
• W2922363098 cites W1990845589 @default.
• W2922363098 cites W2000593460 @default.
• W2922363098 cites W2004672136 @default.
• W2922363098 cites W2015633760 @default.
• W2922363098 cites W2027344845 @default.
• W2922363098 cites W2038019990 @default.
• W2922363098 cites W2049701834 @default.
• W2922363098 cites W2060586414 @default.
• W2922363098 cites W2064542389 @default.
• W2922363098 cites W2065982486 @default.
• W2922363098 cites W2066718981 @default.
• W2922363098 cites W2085792890 @default.
• W2922363098 cites W2097854119 @default.
• W2922363098 cites W2104538381 @default.
• W2922363098 cites W2105820857 @default.
• W2922363098 cites W2113841768 @default.
• W2922363098 cites W2114063564 @default.
• W2922363098 cites W2118340704 @default.
• W2922363098 cites W2136098797 @default.
• W2922363098 cites W2136406415 @default.
• W2922363098 cites W2138932008 @default.
• W2922363098 cites W2145820173 @default.
• W2922363098 cites W2148151469 @default.
• W2922363098 cites W2153579603 @default.
• W2922363098 cites W2160272188 @default.
• W2922363098 cites W2162657919 @default.
• W2922363098 cites W2165380904 @default.
• W2922363098 cites W2168878247 @default.
• W2922363098 cites W2171224841 @default.
• W2922363098 cites W2182067452 @default.
• W2922363098 cites W2619986506 @default.
• W2922363098 cites W2754971264 @default.
• W2922363098 doi "https://doi.org/10.1080/14767058.2019.1596255" @default.
• W2922363098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30880514" @default.
• W2922363098 hasPublicationYear "2019" @default.
• W2922363098 type Work @default.
• W2922363098 sameAs 2922363098 @default.
• W2922363098 citedByCount "5" @default.
• W2922363098 countsByYear W29223630982021 @default.
• W2922363098 countsByYear W29223630982022 @default.
• W2922363098 countsByYear W29223630982023 @default.
• W2922363098 crossrefType "journal-article" @default.
• W2922363098 hasAuthorship W2922363098A5008842025 @default.
• W2922363098 hasAuthorship W2922363098A5033749351 @default.
• W2922363098 hasAuthorship W2922363098A5034206051 @default.
• W2922363098 hasAuthorship W2922363098A5051059039 @default.
• W2922363098 hasAuthorship W2922363098A5062504168 @default.
• W2922363098 hasAuthorship W2922363098A5062790055 @default.
• W2922363098 hasAuthorship W2922363098A5066822950 @default.
• W2922363098 hasAuthorship W2922363098A5067268445 @default.
• W2922363098 hasAuthorship W2922363098A5070951144 @default.
• W2922363098 hasAuthorship W2922363098A5073924079 @default.
• W2922363098 hasAuthorship W2922363098A5087977009 @default.
• W2922363098 hasAuthorship W2922363098A5088297202 @default.
• W2922363098 hasConcept C126322002 @default.
• W2922363098 hasConcept C13373296 @default.
• W2922363098 hasConcept C134018914 @default.
• W2922363098 hasConcept C16685009 @default.
• W2922363098 hasConcept C172680121 @default.
• W2922363098 hasConcept C185592680 @default.
• W2922363098 hasConcept C2776914184 @default.
• W2922363098 hasConcept C2776953305 @default.
• W2922363098 hasConcept C2778754761 @default.
• W2922363098 hasConcept C2779064019 @default.
• W2922363098 hasConcept C2779234561 @default.
• W2922363098 hasConcept C2780197806 @default.
• W2922363098 hasConcept C2780646683 @default.
• W2922363098 hasConcept C2780899479 @default.
• W2922363098 hasConcept C2781184567 @default.
• W2922363098 hasConcept C49039625 @default.
• W2922363098 hasConcept C54355233 @default.
• W2922363098 hasConcept C71315377 @default.
• W2922363098 hasConcept C71924100 @default.

• next