FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922363339> ?p ?o ?g. }

• W2922363339 endingPage "S189" @default.
• W2922363339 startingPage "S188" @default.
• W2922363339 abstract "Purpose: High-volume biliary output, or hypercholeresis, has been rarely reported and not well understood. We report a case of hypercholeresis leading to acute kidney injury and metabolic acidosis following percutaneous transhepatic decompression of a malignant biliary obstruction. Methods: Case: A 73-year-old female presented with one month of nausea, fatigue, weight loss and pruritus. Exam was notable for jaundice and scleral icterus. Labs revealed a total/direct bilirubin of 9.7/6.8 mg/dL and serum creatinine of 0.6 mg/dL. CT showed intrahepatic ductal dilatation without an obvious mass, and ERCP demonstrated a 2-3 cm stricture at the hilum which was brushed and stented; histopathology revealed a cholangiocarcinoma. MRCP confirmed a localized hilar IIIA tumor with persistent biliary dilatation; a percutaneous transhepatic cholangiogram (PTC) was performed, showing considerable dilatation of left ductal branches. An 8.5 French biliary Cope loop catheter was inserted with its tip in the duodenum and side holes in left main duct, with external drainage. Results: The patient was admitted for observation after PTC. Within 10 hours, she had 3750 mL of bile output from the drain; over the next 24 hours, she had 5425 mL of additional output. She then developed hypotension, hyperchloremic metabolic acidosis and oliguric, prerenal acute kidney injury with creatinine of 2.0 mg/dl. Over four days, she had 12.1 liters of bile output. Fluid analysis showed sodium 118 mEq/L, potassium 9.3 mEq/L, chloride 93 mEq/L and a bilirubin of 461 mcg/mL, without infection. She was rehydrated with >15 liters of lactated Ringer's, and her creatinine improved to baseline. Her drain output decreased after 4 days, and she underwent right hepatectomy, common bile duct resection and a Roux-en-Y left hepaticojejunostomy, doing well post-operatively. Conclusion: Discussion: Normal bile output ranges from 250-1100 mL daily, and although high-volume biliary output (>2000 mL/day) is rare, it has been reported with T-tube drainage after ductal exploration, a choledochocutaneous fistula, and after percutaneous transhepatic drainage of biliary obstruction. The reason for this increased output is unknown, but may be related to osmotic effects of bile acids after prolonged obstruction. Given the uncommon nature of hypercholeresis, there are no known predictors to allow providers to stratify a patient's risk after PTC, so awareness of this rare outcome is essential to adequately counsel patients." @default.
• W2922363339 created "2019-03-22" @default.
• W2922363339 creator A5006815406 @default.
• W2922363339 creator A5052441786 @default.
• W2922363339 creator A5077792271 @default.
• W2922363339 creator A5087106529 @default.
• W2922363339 date "2010-10-01" @default.
• W2922363339 modified "2023-09-24" @default.
• W2922363339 title "How Much Bile is Too Much? A Case of Post-Obstructive Hypercholeresis" @default.
• W2922363339 doi "https://doi.org/10.14309/00000434-201010001-00518" @default.
• W2922363339 hasPublicationYear "2010" @default.
• W2922363339 type Work @default.
• W2922363339 sameAs 2922363339 @default.
• W2922363339 citedByCount "0" @default.
• W2922363339 crossrefType "journal-article" @default.
• W2922363339 hasAuthorship W2922363339A5006815406 @default.
• W2922363339 hasAuthorship W2922363339A5052441786 @default.
• W2922363339 hasAuthorship W2922363339A5077792271 @default.
• W2922363339 hasAuthorship W2922363339A5087106529 @default.
• W2922363339 hasConcept C126322002 @default.
• W2922363339 hasConcept C126894567 @default.
• W2922363339 hasConcept C141071460 @default.
• W2922363339 hasConcept C2776884468 @default.
• W2922363339 hasConcept C2777513400 @default.
• W2922363339 hasConcept C2778456037 @default.
• W2922363339 hasConcept C2779246250 @default.
• W2922363339 hasConcept C2779777945 @default.
• W2922363339 hasConcept C2779819216 @default.
• W2922363339 hasConcept C2780306776 @default.
• W2922363339 hasConcept C2780472472 @default.
• W2922363339 hasConcept C71924100 @default.
• W2922363339 hasConcept C90924648 @default.
• W2922363339 hasConceptScore W2922363339C126322002 @default.
• W2922363339 hasConceptScore W2922363339C126894567 @default.
• W2922363339 hasConceptScore W2922363339C141071460 @default.
• W2922363339 hasConceptScore W2922363339C2776884468 @default.
• W2922363339 hasConceptScore W2922363339C2777513400 @default.
• W2922363339 hasConceptScore W2922363339C2778456037 @default.
• W2922363339 hasConceptScore W2922363339C2779246250 @default.
• W2922363339 hasConceptScore W2922363339C2779777945 @default.
• W2922363339 hasConceptScore W2922363339C2779819216 @default.
• W2922363339 hasConceptScore W2922363339C2780306776 @default.
• W2922363339 hasConceptScore W2922363339C2780472472 @default.
• W2922363339 hasConceptScore W2922363339C71924100 @default.
• W2922363339 hasConceptScore W2922363339C90924648 @default.
• W2922363339 hasLocation W29223633391 @default.
• W2922363339 hasOpenAccess W2922363339 @default.
• W2922363339 hasPrimaryLocation W29223633391 @default.
• W2922363339 hasRelatedWork W1193443216 @default.
• W2922363339 hasRelatedWork W163187928 @default.
• W2922363339 hasRelatedWork W2062935353 @default.
• W2922363339 hasRelatedWork W2082820084 @default.
• W2922363339 hasRelatedWork W2092421559 @default.
• W2922363339 hasRelatedWork W2373481473 @default.
• W2922363339 hasRelatedWork W2440823168 @default.
• W2922363339 hasRelatedWork W2474903143 @default.
• W2922363339 hasRelatedWork W2796180366 @default.
• W2922363339 hasRelatedWork W2887219498 @default.
• W2922363339 hasVolume "105" @default.
• W2922363339 isParatext "false" @default.
• W2922363339 isRetracted "false" @default.
• W2922363339 magId "2922363339" @default.
• W2922363339 workType "article" @default.