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- W2922381007 abstract "Abstract The Pseudomonas quinolone signal (PQS) is a multifunctional quorum sensing molecule of key importance to the P. aeruginosa metabolism. We here describe that the lytic Pseudomonas bacterial virus LUZ19 targets this population-density-dependent signaling system by expressing q uorum s ensing-associated acyl t ransferase (Qst) during early infection. Qst interacts with a key biosynthesis pathway enzyme PqsD, resulting in decreased metabolites levels of PQS and its precursor 2-heptyl-4(1H)-quinolone. The lack of a functional PqsD enzyme impairs the normal LUZ19 infection but is restored by external supplementation of 2-heptyl-4(1H)-quinolone, showing that LUZ19 exploits PQS to successfully achieve its infection. A functional interaction network, which includes enzymes of the central carbon metabolism (CoaC/ThiD) and a novel non-ribosomal peptide synthetase pathway (PA1217), suggests a broader functional context for Qst, which blocks P. aeruginosa cell division. Qst represents an exquisite example of intricate reprogramming of the bacterium, which may be exploited towards antibiotic target discovery for this bacterial pathogen." @default.
- W2922381007 created "2019-03-22" @default.
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- W2922381007 date "2019-03-16" @default.
- W2922381007 modified "2023-09-26" @default.
- W2922381007 title "Host metabolic reprogramming of Pseudomonas aeruginosa by phage-based quorum sensing modulation" @default.
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- W2922381007 doi "https://doi.org/10.1101/577908" @default.
- W2922381007 hasPublicationYear "2019" @default.
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