Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922385763> ?p ?o ?g. }
- W2922385763 endingPage "e14026" @default.
- W2922385763 startingPage "e14026" @default.
- W2922385763 abstract "Emerging evidence suggests that sex differences exist in the control of lung innate immunity; however, the specific roles of sex hormones in the inflammatory response, and the mechanisms involved are unclear. Here, we investigated whether fluctuations in circulating hormone levels occurring in the mouse estrous cycle could affect the inflammatory response to air pollution exposure. For this, we exposed female mice (C57BL/6J, 8 weeks old) at different phases of the estrous cycle to 2 ppm of ozone or filtered air (FA) for 3 h. Following exposure, we collected lung tissue and bronchoalveolar lavage fluid (BAL), and performed lung function measurements to evaluate inflammatory responses and respiratory mechanics. We found a differential inflammatory response to ozone in females exposed in the luteal phase (metestrus, diestrus) versus the follicular phase (proestrus, estrus). Females exposed to ozone in the follicular phase had significantly higher expression of inflammatory genes, including Ccl2, Cxcl2, Ccl20, and Il6, compared to females exposed in the luteal phase (P < 0.05), and displayed differential activation of regulatory pathways. Exposure to ozone in the follicular phase also resulted in higher BAL neutrophilia, lipocalin levels, and airway resistance than exposure in the luteal phase (P < 0.05). Together, these results show that the effects of ozone exposure in the female lung are affected by the estrous cycle phase, and potentially hormonal status. Future studies investigating air pollution effects and inflammation in women should consider the menstrual cycle phase and/or circulating hormone levels." @default.
- W2922385763 created "2019-03-22" @default.
- W2922385763 creator A5034207382 @default.
- W2922385763 creator A5043445718 @default.
- W2922385763 creator A5043539183 @default.
- W2922385763 creator A5052979418 @default.
- W2922385763 creator A5062797423 @default.
- W2922385763 date "2019-03-01" @default.
- W2922385763 modified "2023-10-16" @default.
- W2922385763 title "Modulation of the lung inflammatory response to ozone by the estrous cycle" @default.
- W2922385763 cites W1512733937 @default.
- W2922385763 cites W1965883545 @default.
- W2922385763 cites W1967205811 @default.
- W2922385763 cites W1969860294 @default.
- W2922385763 cites W1975731098 @default.
- W2922385763 cites W1978611150 @default.
- W2922385763 cites W1985995428 @default.
- W2922385763 cites W2005916772 @default.
- W2922385763 cites W2006754766 @default.
- W2922385763 cites W2010497705 @default.
- W2922385763 cites W2011569188 @default.
- W2922385763 cites W2014545138 @default.
- W2922385763 cites W2016264305 @default.
- W2922385763 cites W2040026684 @default.
- W2922385763 cites W2041292755 @default.
- W2922385763 cites W2042152630 @default.
- W2922385763 cites W2049144654 @default.
- W2922385763 cites W2050465723 @default.
- W2922385763 cites W2077258706 @default.
- W2922385763 cites W2078981058 @default.
- W2922385763 cites W2083753594 @default.
- W2922385763 cites W2096790979 @default.
- W2922385763 cites W2097762666 @default.
- W2922385763 cites W2107277218 @default.
- W2922385763 cites W2107881000 @default.
- W2922385763 cites W2110065044 @default.
- W2922385763 cites W2126003582 @default.
- W2922385763 cites W2126181705 @default.
- W2922385763 cites W2133180000 @default.
- W2922385763 cites W2147120129 @default.
- W2922385763 cites W2152505277 @default.
- W2922385763 cites W2162296057 @default.
- W2922385763 cites W2165853736 @default.
- W2922385763 cites W2167123485 @default.
- W2922385763 cites W2167514696 @default.
- W2922385763 cites W2172467955 @default.
- W2922385763 cites W2183998942 @default.
- W2922385763 cites W2192080449 @default.
- W2922385763 cites W2275778827 @default.
- W2922385763 cites W2291170577 @default.
- W2922385763 cites W2333339461 @default.
- W2922385763 cites W2369611914 @default.
- W2922385763 cites W2405019496 @default.
- W2922385763 cites W25125631 @default.
- W2922385763 cites W2530132793 @default.
- W2922385763 cites W2547522166 @default.
- W2922385763 cites W2586753232 @default.
- W2922385763 cites W2587873400 @default.
- W2922385763 cites W2602783738 @default.
- W2922385763 cites W2604448703 @default.
- W2922385763 cites W2740317253 @default.
- W2922385763 cites W2740628813 @default.
- W2922385763 cites W2741465559 @default.
- W2922385763 cites W2743080541 @default.
- W2922385763 cites W2787648779 @default.
- W2922385763 cites W2803598168 @default.
- W2922385763 cites W2807280898 @default.
- W2922385763 cites W2885228297 @default.
- W2922385763 cites W2888012767 @default.
- W2922385763 cites W2899736836 @default.
- W2922385763 cites W2903234174 @default.
- W2922385763 cites W2905350932 @default.
- W2922385763 cites W2912248177 @default.
- W2922385763 cites W2922385763 @default.
- W2922385763 cites W4246230944 @default.
- W2922385763 cites W4252672757 @default.
- W2922385763 cites W4301024644 @default.
- W2922385763 cites W817098076 @default.
- W2922385763 doi "https://doi.org/10.14814/phy2.14026" @default.
- W2922385763 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6405886" @default.
- W2922385763 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30848106" @default.
- W2922385763 hasPublicationYear "2019" @default.
- W2922385763 type Work @default.
- W2922385763 sameAs 2922385763 @default.
- W2922385763 citedByCount "27" @default.
- W2922385763 countsByYear W29223857632019 @default.
- W2922385763 countsByYear W29223857632020 @default.
- W2922385763 countsByYear W29223857632021 @default.
- W2922385763 countsByYear W29223857632022 @default.
- W2922385763 countsByYear W29223857632023 @default.
- W2922385763 crossrefType "journal-article" @default.
- W2922385763 hasAuthorship W2922385763A5034207382 @default.
- W2922385763 hasAuthorship W2922385763A5043445718 @default.
- W2922385763 hasAuthorship W2922385763A5043539183 @default.
- W2922385763 hasAuthorship W2922385763A5052979418 @default.
- W2922385763 hasAuthorship W2922385763A5062797423 @default.
- W2922385763 hasBestOaLocation W29223857631 @default.
- W2922385763 hasConcept C126322002 @default.