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• W2922389470 abstract "Salvianolic acid A (SAA) is a bioactive polyphenol extracted from Salviae miltiorrhizae Bunge, which possesses a variety of pharmacological activities. In our previous study, we have demonstrated that SAA effectively attenuates kidney injury and inflammation in an established animal model of 5/6 nephrectomized (5/6Nx) rats. However, there has been limited research regarding the antioxidative effects of SAA on chronic kidney disease (CKD). Here, we examined the antioxidative effects and underlying mechanisms of SAA in 5/6Nx rats. The rats were injected with SAA (2.5, 5, and 10 mg·kg -1 ·d -1 , ip) for 28 days. Biochemical, flow cytometry, and Western blot analyses showed that SAA significantly increased the activities of total superoxide dismutase (T-SOD), glutathione peroxidase (GPx), and catalase (CAT) and lowered the levels of malondialdehyde (MDA), reactive oxygen species (ROS), and NADPH oxidase 4 (NOX-4) in a dose-dependent manner in 5/6Nx rats and in H 2 O 2 -induced HK-2 cells in vitro . Moreover, SAA enhanced the activation of the protein kinase B/glycogen synthase kinase-3 β /nuclear factor-erythroid-2-related factor 2 (Akt/GSK-3 β /Nrf2) signaling pathway in a dose-dependent manner and subsequently increased the expression of heme oxygenase-1 (HO-1) in the kidney of 5/6Nx rats, which were consistent with those obtained in H 2 O 2 -induced HK-2 cells in vitro shown by Western blot analysis. Furthermore, SAA significantly increased the expression of intranuclear Nrf2 and HO-1 proteins compared to HK-2 cells stimulated by LPS on the one hand, which can be enhanced by QNZ to some extent; on the other hand, SAA significantly lowered the expression of p-NF- κ B p65 and ICAM-1 proteins compared to HK-2 cells stimulated by H 2 O 2 , which can be abrogated by ML385 to some extent. In conclusion, our results demonstrated that SAA effectively protects the kidney against oxidative stress in 5/6Nx rats. One of the pivotal mechanisms for the protective effects of SAA on kidney injury was mainly related with its antioxidative roles by activating the Akt/GSK-3 β /Nrf2 signaling pathway and inhibiting the NF- κ B signaling pathway." @default.
• W2922389470 created "2019-03-22" @default.
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• W2922389470 date "2019-03-18" @default.
• W2922389470 modified "2023-10-16" @default.
• W2922389470 title "Salvianolic Acid A Protects the Kidney against Oxidative Stress by Activating the Akt/GSK-3<i>β</i>/Nrf2 Signaling Pathway and Inhibiting the NF-<i>κ</i>B Signaling Pathway in 5/6 Nephrectomized Rats" @default.
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• W2922389470 doi "https://doi.org/10.1155/2019/2853534" @default.
• W2922389470 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6442489" @default.
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