Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922415308> ?p ?o ?g. }
- W2922415308 endingPage "9" @default.
- W2922415308 startingPage "1" @default.
- W2922415308 abstract "Methods . Human ARPE-19 cells engineered to secrete high levels of the glial cell line-derived neurotrophic factor (GDNF) were encapsulated into hollow fiber membranes. The devices were implanted into the rat striatum 1 week prior to striatal quinolinic acid injections. Animals were evaluated using a battery of validated motor tests, and histology was performed to determine the extent of GDNF diffusion and associated prevention of neuronal cell loss and behavioral deficits. Results . Encapsulated cell-based delivery of GDNF produced widespread distribution of GDNF throughout the entire implanted striatum. Stereological estimates of striatal neuron number and volume of lesion size revealed that GDNF delivery resulted in near complete neuroprotection. Conclusions . Delivery of neurotrophic molecules such as GDNF using encapsulated cells has reached a technological point where clinical evaluation is justified. Because GDNF has been effective in animal models of Parkinson’s disease, stroke, epilepsy, and Huntington’s disease, among other debilitating neurodegenerative diseases, encapsulated cell-based delivery of GDNF might represent one innovative means of slowing the neural degeneration seen in a myriad of currently untreatable neurological diseases." @default.
- W2922415308 created "2019-03-22" @default.
- W2922415308 creator A5000544131 @default.
- W2922415308 creator A5017581245 @default.
- W2922415308 creator A5053688298 @default.
- W2922415308 creator A5058329121 @default.
- W2922415308 creator A5074765508 @default.
- W2922415308 creator A5077753619 @default.
- W2922415308 creator A5081117993 @default.
- W2922415308 date "2019-03-11" @default.
- W2922415308 modified "2023-09-27" @default.
- W2922415308 title "Widespread Striatal Delivery of GDNF from Encapsulated Cells Prevents the Anatomical and Functional Consequences of Excitotoxicity" @default.
- W2922415308 cites W1479712018 @default.
- W2922415308 cites W18842890 @default.
- W2922415308 cites W1968245867 @default.
- W2922415308 cites W1969882081 @default.
- W2922415308 cites W1971258758 @default.
- W2922415308 cites W1973502470 @default.
- W2922415308 cites W1979264516 @default.
- W2922415308 cites W1987050568 @default.
- W2922415308 cites W1991208841 @default.
- W2922415308 cites W1997631088 @default.
- W2922415308 cites W1999128801 @default.
- W2922415308 cites W2002741808 @default.
- W2922415308 cites W2008503216 @default.
- W2922415308 cites W2010395737 @default.
- W2922415308 cites W2019695510 @default.
- W2922415308 cites W2024630482 @default.
- W2922415308 cites W2027604698 @default.
- W2922415308 cites W2030512990 @default.
- W2922415308 cites W2032744846 @default.
- W2922415308 cites W2033373933 @default.
- W2922415308 cites W2034110115 @default.
- W2922415308 cites W2036748407 @default.
- W2922415308 cites W2041676728 @default.
- W2922415308 cites W2047955009 @default.
- W2922415308 cites W2051834632 @default.
- W2922415308 cites W2051871118 @default.
- W2922415308 cites W2069311390 @default.
- W2922415308 cites W2075594601 @default.
- W2922415308 cites W2076686536 @default.
- W2922415308 cites W2079367950 @default.
- W2922415308 cites W2093522076 @default.
- W2922415308 cites W2096048446 @default.
- W2922415308 cites W2101099825 @default.
- W2922415308 cites W2106179404 @default.
- W2922415308 cites W2107155103 @default.
- W2922415308 cites W2108724455 @default.
- W2922415308 cites W2117516229 @default.
- W2922415308 cites W2121642311 @default.
- W2922415308 cites W2133781582 @default.
- W2922415308 cites W2163916988 @default.
- W2922415308 cites W2165526364 @default.
- W2922415308 cites W2789376325 @default.
- W2922415308 cites W2792121520 @default.
- W2922415308 cites W2901164297 @default.
- W2922415308 cites W2910152620 @default.
- W2922415308 cites W4232045797 @default.
- W2922415308 cites W4245890209 @default.
- W2922415308 cites W4379371205 @default.
- W2922415308 doi "https://doi.org/10.1155/2019/6286197" @default.
- W2922415308 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6432730" @default.
- W2922415308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30984255" @default.
- W2922415308 hasPublicationYear "2019" @default.
- W2922415308 type Work @default.
- W2922415308 sameAs 2922415308 @default.
- W2922415308 citedByCount "10" @default.
- W2922415308 countsByYear W29224153082019 @default.
- W2922415308 countsByYear W29224153082020 @default.
- W2922415308 countsByYear W29224153082021 @default.
- W2922415308 countsByYear W29224153082022 @default.
- W2922415308 countsByYear W29224153082023 @default.
- W2922415308 crossrefType "journal-article" @default.
- W2922415308 hasAuthorship W2922415308A5000544131 @default.
- W2922415308 hasAuthorship W2922415308A5017581245 @default.
- W2922415308 hasAuthorship W2922415308A5053688298 @default.
- W2922415308 hasAuthorship W2922415308A5058329121 @default.
- W2922415308 hasAuthorship W2922415308A5074765508 @default.
- W2922415308 hasAuthorship W2922415308A5077753619 @default.
- W2922415308 hasAuthorship W2922415308A5081117993 @default.
- W2922415308 hasBestOaLocation W29224153081 @default.
- W2922415308 hasConcept C126322002 @default.
- W2922415308 hasConcept C160539049 @default.
- W2922415308 hasConcept C169760540 @default.
- W2922415308 hasConcept C170493617 @default.
- W2922415308 hasConcept C185856081 @default.
- W2922415308 hasConcept C25498285 @default.
- W2922415308 hasConcept C2780062018 @default.
- W2922415308 hasConcept C2781012912 @default.
- W2922415308 hasConcept C513476851 @default.
- W2922415308 hasConcept C67018056 @default.
- W2922415308 hasConcept C71924100 @default.
- W2922415308 hasConcept C86803240 @default.
- W2922415308 hasConceptScore W2922415308C126322002 @default.
- W2922415308 hasConceptScore W2922415308C160539049 @default.
- W2922415308 hasConceptScore W2922415308C169760540 @default.
- W2922415308 hasConceptScore W2922415308C170493617 @default.
- W2922415308 hasConceptScore W2922415308C185856081 @default.