Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922455135> ?p ?o ?g. }
- W2922455135 endingPage "6145" @default.
- W2922455135 startingPage "6140" @default.
- W2922455135 abstract "Significance Colorectal cancer (CRC) is a heterogeneous disease, with significant variation in genotype and phenotype within each individual tumor. This intratumor heterogeneity emerges during tumor development due to clonal evolution and in part can explain therapy resistance in CRC. However, a detailed understanding of the spatiotemporal development of tumors underlying cancer evolution and intratumor heterogeneity remains absent. Here, we use lineage-tracing experiments of human CRC cells transplanted into immunocompromised mice, in combination with computational modeling, to study the growth mode of CRC. We found that the clonal position is crucial for clonal outgrowth. This demonstrates that, in addition to the genetic composition, the environment and the geometry of tumor growth play a significant role in shaping tumor evolution." @default.
- W2922455135 created "2019-03-22" @default.
- W2922455135 creator A5000404080 @default.
- W2922455135 creator A5000969662 @default.
- W2922455135 creator A5003271927 @default.
- W2922455135 creator A5020889972 @default.
- W2922455135 creator A5023563715 @default.
- W2922455135 creator A5026556161 @default.
- W2922455135 creator A5026615754 @default.
- W2922455135 creator A5035211563 @default.
- W2922455135 creator A5036798094 @default.
- W2922455135 creator A5039493798 @default.
- W2922455135 creator A5039594270 @default.
- W2922455135 creator A5043831964 @default.
- W2922455135 creator A5046618040 @default.
- W2922455135 creator A5048096504 @default.
- W2922455135 creator A5048348175 @default.
- W2922455135 creator A5051358028 @default.
- W2922455135 creator A5062292279 @default.
- W2922455135 creator A5063711841 @default.
- W2922455135 creator A5063725205 @default.
- W2922455135 creator A5081956768 @default.
- W2922455135 date "2019-03-08" @default.
- W2922455135 modified "2023-10-18" @default.
- W2922455135 title "Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts" @default.
- W2922455135 cites W1968969468 @default.
- W2922455135 cites W2001258296 @default.
- W2922455135 cites W2009134460 @default.
- W2922455135 cites W2009359422 @default.
- W2922455135 cites W2010873488 @default.
- W2922455135 cites W2020131167 @default.
- W2922455135 cites W2043772256 @default.
- W2922455135 cites W2051055358 @default.
- W2922455135 cites W2078012053 @default.
- W2922455135 cites W2078510083 @default.
- W2922455135 cites W2123303153 @default.
- W2922455135 cites W2125636389 @default.
- W2922455135 cites W2129644533 @default.
- W2922455135 cites W2135163856 @default.
- W2922455135 cites W2135523574 @default.
- W2922455135 cites W2135925682 @default.
- W2922455135 cites W2140080780 @default.
- W2922455135 cites W2147650118 @default.
- W2922455135 cites W2162756888 @default.
- W2922455135 cites W2737053924 @default.
- W2922455135 cites W2767623442 @default.
- W2922455135 cites W2798041799 @default.
- W2922455135 cites W2886855629 @default.
- W2922455135 cites W2888063818 @default.
- W2922455135 doi "https://doi.org/10.1073/pnas.1813417116" @default.
- W2922455135 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6442578" @default.
- W2922455135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30850544" @default.
- W2922455135 hasPublicationYear "2019" @default.
- W2922455135 type Work @default.
- W2922455135 sameAs 2922455135 @default.
- W2922455135 citedByCount "54" @default.
- W2922455135 countsByYear W29224551352019 @default.
- W2922455135 countsByYear W29224551352020 @default.
- W2922455135 countsByYear W29224551352021 @default.
- W2922455135 countsByYear W29224551352022 @default.
- W2922455135 countsByYear W29224551352023 @default.
- W2922455135 crossrefType "journal-article" @default.
- W2922455135 hasAuthorship W2922455135A5000404080 @default.
- W2922455135 hasAuthorship W2922455135A5000969662 @default.
- W2922455135 hasAuthorship W2922455135A5003271927 @default.
- W2922455135 hasAuthorship W2922455135A5020889972 @default.
- W2922455135 hasAuthorship W2922455135A5023563715 @default.
- W2922455135 hasAuthorship W2922455135A5026556161 @default.
- W2922455135 hasAuthorship W2922455135A5026615754 @default.
- W2922455135 hasAuthorship W2922455135A5035211563 @default.
- W2922455135 hasAuthorship W2922455135A5036798094 @default.
- W2922455135 hasAuthorship W2922455135A5039493798 @default.
- W2922455135 hasAuthorship W2922455135A5039594270 @default.
- W2922455135 hasAuthorship W2922455135A5043831964 @default.
- W2922455135 hasAuthorship W2922455135A5046618040 @default.
- W2922455135 hasAuthorship W2922455135A5048096504 @default.
- W2922455135 hasAuthorship W2922455135A5048348175 @default.
- W2922455135 hasAuthorship W2922455135A5051358028 @default.
- W2922455135 hasAuthorship W2922455135A5062292279 @default.
- W2922455135 hasAuthorship W2922455135A5063711841 @default.
- W2922455135 hasAuthorship W2922455135A5063725205 @default.
- W2922455135 hasAuthorship W2922455135A5081956768 @default.
- W2922455135 hasBestOaLocation W29224551351 @default.
- W2922455135 hasConcept C104317684 @default.
- W2922455135 hasConcept C113968399 @default.
- W2922455135 hasConcept C121608353 @default.
- W2922455135 hasConcept C127716648 @default.
- W2922455135 hasConcept C135763542 @default.
- W2922455135 hasConcept C2776817793 @default.
- W2922455135 hasConcept C502942594 @default.
- W2922455135 hasConcept C526805850 @default.
- W2922455135 hasConcept C54355233 @default.
- W2922455135 hasConcept C64618202 @default.
- W2922455135 hasConcept C86803240 @default.
- W2922455135 hasConceptScore W2922455135C104317684 @default.
- W2922455135 hasConceptScore W2922455135C113968399 @default.
- W2922455135 hasConceptScore W2922455135C121608353 @default.
- W2922455135 hasConceptScore W2922455135C127716648 @default.