Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922458694> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2922458694 abstract "This thesis describes the synthesis of fluorinated cyclopropane analogues to enhance the metabolic stability of a previously published lead candidate for prostate cancer treatment. A structural unique motif such as the bicyclo[1.1.0]pentane was also incorporated to investigate its potential as cyclopropane bioisostere. Preliminary results from liver microsome and luciferase assays suggested that fluorinations on the cyclopropane carbon atoms have little impact on the metabolic stability. However, fluorination on other labile sites showed enhanced metabolic stability while retaining compound potency. An enantioselective route to improve the original racemic synthesis of these analogues was also investigated. The key step was a Co(II)-salen catalyzed enantioselective cis-cyclopropanation of an olefin with ethyl diazoacetate to provide the cyclopropyl amide in 98% ee over three high-yielding steps." @default.
- W2922458694 created "2019-03-22" @default.
- W2922458694 creator A5087437454 @default.
- W2922458694 date "2018-09-26" @default.
- W2922458694 modified "2023-09-27" @default.
- W2922458694 title "Synthesis of Small Molecule Antagonists at the Androgen Receptor for Prostate Cancer Treatment and Efforts Toward an Enantioselective Co(II)-Catalyzed Cyclopropanation" @default.
- W2922458694 hasPublicationYear "2018" @default.
- W2922458694 type Work @default.
- W2922458694 sameAs 2922458694 @default.
- W2922458694 citedByCount "0" @default.
- W2922458694 crossrefType "journal-article" @default.
- W2922458694 hasAuthorship W2922458694A5087437454 @default.
- W2922458694 hasConcept C114373084 @default.
- W2922458694 hasConcept C146686406 @default.
- W2922458694 hasConcept C161790260 @default.
- W2922458694 hasConcept C178790620 @default.
- W2922458694 hasConcept C185592680 @default.
- W2922458694 hasConcept C202751555 @default.
- W2922458694 hasConcept C21951064 @default.
- W2922458694 hasConcept C2777052750 @default.
- W2922458694 hasConcept C2779095896 @default.
- W2922458694 hasConcept C2779200411 @default.
- W2922458694 hasConcept C2780378348 @default.
- W2922458694 hasConcept C55493867 @default.
- W2922458694 hasConcept C71240020 @default.
- W2922458694 hasConceptScore W2922458694C114373084 @default.
- W2922458694 hasConceptScore W2922458694C146686406 @default.
- W2922458694 hasConceptScore W2922458694C161790260 @default.
- W2922458694 hasConceptScore W2922458694C178790620 @default.
- W2922458694 hasConceptScore W2922458694C185592680 @default.
- W2922458694 hasConceptScore W2922458694C202751555 @default.
- W2922458694 hasConceptScore W2922458694C21951064 @default.
- W2922458694 hasConceptScore W2922458694C2777052750 @default.
- W2922458694 hasConceptScore W2922458694C2779095896 @default.
- W2922458694 hasConceptScore W2922458694C2779200411 @default.
- W2922458694 hasConceptScore W2922458694C2780378348 @default.
- W2922458694 hasConceptScore W2922458694C55493867 @default.
- W2922458694 hasConceptScore W2922458694C71240020 @default.
- W2922458694 hasLocation W29224586941 @default.
- W2922458694 hasOpenAccess W2922458694 @default.
- W2922458694 hasPrimaryLocation W29224586941 @default.
- W2922458694 hasRelatedWork W1971505974 @default.
- W2922458694 hasRelatedWork W1996195474 @default.
- W2922458694 hasRelatedWork W1997519247 @default.
- W2922458694 hasRelatedWork W2055285739 @default.
- W2922458694 hasRelatedWork W2082924421 @default.
- W2922458694 hasRelatedWork W2085949895 @default.
- W2922458694 hasRelatedWork W2094855248 @default.
- W2922458694 hasRelatedWork W2103661111 @default.
- W2922458694 hasRelatedWork W2179990755 @default.
- W2922458694 hasRelatedWork W2268545489 @default.
- W2922458694 hasRelatedWork W2288900729 @default.
- W2922458694 hasRelatedWork W2317115327 @default.
- W2922458694 hasRelatedWork W2763793342 @default.
- W2922458694 hasRelatedWork W2779263012 @default.
- W2922458694 hasRelatedWork W2789863026 @default.
- W2922458694 hasRelatedWork W2949654515 @default.
- W2922458694 hasRelatedWork W2950085225 @default.
- W2922458694 hasRelatedWork W2950615242 @default.
- W2922458694 hasRelatedWork W2950936507 @default.
- W2922458694 hasRelatedWork W605225630 @default.
- W2922458694 isParatext "false" @default.
- W2922458694 isRetracted "false" @default.
- W2922458694 magId "2922458694" @default.
- W2922458694 workType "article" @default.