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• W2922461110 abstract "Purpose: Endoscopic ultrasound (EUS) guided fine needle aspiration (FNA) is emerging as the preferred method for the diagnosis of pancreatic masses. Diagnostic accuracy is variable, with reported rates ranging from 65 to 95%. The goal of our study was to determine if clinical or endosonographic features such as location, size or echofeatures of the tumor can predict the accuracy of FNA. Methods: A retrospective study was performed on all patients referred to a single tertiary care center for EUS-FNA of a solid pancreatic mass from August 2007 to June 2009. All procedures were performed by a single endosonographer, with in-room cytopathology. All patients had a positive diagnosis of cancer confirmed by surgical pathology. Patients with pathology proven benign disease via a surgical specimen were excluded from the study. Results: 61 patients (32 male) were identified. The mean age of the patients was 66.6±12.7 years. Forty six patients (75%) with a mass in the pancreas had positive cytology for adenocarcinoma, of which 39 had solid masses and 7 had mixed features (solid and cystic components). Fifteen patients (25%) had non-definitive cytology (negative, suspicious or atypical findings), of which 9 had solid masses and 6 had mixed features. The predictive value of solid vs. mixed features in determining cytology yield did not reach clinical significance (p= 0.67). The average size of the positive lesions was 3.54 cm (SD 1.0093) and 3.34 cm (SD 1.0903) for the negative lesions, with a p value of 0.54. The location of the masses were also compared with 33 of 43 (76.7%) masses positive in the head/uncinate of the pancreas and 13 of 18 (72.2%) positive in the body/tail of the pancreas (p=0.75). Clinical features such as abdominal pain, jaundice, weight loss, diabetes mellitus, or history of pancreatitis showed no significance in predicting accuracy of FNA. Of note, reclassification of suspicious and atypical findings to positive results increased the overall accuracy of FNA to 85%, but again clinical and endosonographic features did not reach clinical significance. Conclusion: EUS-FNA has emerged as an important tool for the diagnosis of pancreatic tumors, allowing a tissue diagnosis prior to surgery. Our study did not reveal any predictive variables amongst clinical features or endosonographic features that could increase the accuracy of FNA." @default.
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• W2922461110 date "2010-10-01" @default.
• W2922461110 modified "2023-10-17" @default.
• W2922461110 title "The Role of Clinical and Endosonographic Features in Predicting the Accuracy of Endoscopic Ultrasound Guided Fine Needle Aspiration" @default.
• W2922461110 doi "https://doi.org/10.14309/00000434-201010001-00163" @default.
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