FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922483141> ?p ?o ?g. }

• W2922483141 abstract "Genital C. trachomatis infection may cause pelvic inflammatory disease (PID) that can lead to tubal factor infertility (TFI). Understanding the pathogenesis of chlamydial complications including the pathophysiological processes within the female host genital tract is important in preventing adverse pathology. MicroRNAs regulate several pathophysiological processes of infectious and non-infectious etiologies. In this study, we tested the hypothesis that the miRNA profile of single and repeat genital chlamydial infections will be different and that these differences will be time dependent. Thus, we analyzed and compared differentially expressed mice genital tract miRNAs after single and repeat chlamydia infections using a C. muridarum mouse model. Mice were sacrificed and their genital tract tissues were collected at 1, 2, 4, and 8 weeks after a single and repeat chlamydia infections. Histopathology, and miRNA sequencing were performed. Histopathology presentation showed that the oviduct and uterus of reinfected mice were more inflamed, distended and dilated compared to mice infected once. The miRNAs expression profile was different in the reproductive tissues after a reinfection, with a greater number of miRNAs expressed after reinfection. Also, the number of miRNAs expressed each week after chlamydia infection and reinfection varied, with weeks eight and one having the highest number of differentially expressed miRNAs for chlamydia infection and reinfection respectively. Ten miRNAs; mmu-miR-378b, mmu-miR-204-5p, mmu-miR-151-5p, mmu-miR-142-3p, mmu-miR-128-3p, mmu-miR-335-3p, mmu-miR-195a-3p, mmu-miR-142-5p, mmu-miR-106a-5p and mmu-miR-92a-3p were common in both primary chlamydia infection and reinfection. Pathway analysis showed that, amongst other functions, the differentially regulated miRNAs control pathways involved in cellular and tissue development, disease conditions and toxicity. This study provides insights into the changes in miRNA expression over time after chlamydia infection and reinfection, as well as the pathways they regulate to determine pathological outcomes. The miRNAs networks generated in our study shows that there are differences in the focus molecules involved in significant biological functions in chlamydia infection and reinfection, implying that chlamydial pathogenesis occurs differently for each type of infection and that this could be important when determining treatments regime and disease outcome. The study underscores the crucial role of host factors in chlamydia pathogenesis." @default.
• W2922483141 created "2019-03-22" @default.
• W2922483141 creator A5005169500 @default.
• W2922483141 creator A5012979418 @default.
• W2922483141 creator A5015617830 @default.
• W2922483141 creator A5023593380 @default.
• W2922483141 creator A5024363658 @default.
• W2922483141 creator A5025012407 @default.
• W2922483141 creator A5035329514 @default.
• W2922483141 creator A5036900001 @default.
• W2922483141 creator A5038865787 @default.
• W2922483141 creator A5053472373 @default.
• W2922483141 creator A5054143765 @default.
• W2922483141 creator A5057852995 @default.
• W2922483141 creator A5073348196 @default.
• W2922483141 creator A5073655805 @default.
• W2922483141 creator A5075872284 @default.
• W2922483141 creator A5076001164 @default.
• W2922483141 creator A5080605949 @default.
• W2922483141 creator A5081195057 @default.
• W2922483141 date "2019-02-18" @default.
• W2922483141 modified "2023-10-18" @default.
• W2922483141 title "A unique insight into the MiRNA profile during genital chlamydial infection" @default.
• W2922483141 cites W1502979477 @default.
• W2922483141 cites W1585791945 @default.
• W2922483141 cites W1609044025 @default.
• W2922483141 cites W1674006573 @default.
• W2922483141 cites W1865855039 @default.
• W2922483141 cites W1911559258 @default.
• W2922483141 cites W1975823101 @default.
• W2922483141 cites W1979652158 @default.
• W2922483141 cites W1988208510 @default.
• W2922483141 cites W1992825004 @default.
• W2922483141 cites W1993165035 @default.
• W2922483141 cites W1995896010 @default.
• W2922483141 cites W1999306757 @default.
• W2922483141 cites W2005428616 @default.
• W2922483141 cites W2011202167 @default.
• W2922483141 cites W2021044235 @default.
• W2922483141 cites W2042673698 @default.
• W2922483141 cites W2058169359 @default.
• W2922483141 cites W2062010389 @default.
• W2922483141 cites W2065982844 @default.
• W2922483141 cites W2070161604 @default.
• W2922483141 cites W2070738304 @default.
• W2922483141 cites W2094376465 @default.
• W2922483141 cites W2096310503 @default.
• W2922483141 cites W2098304796 @default.
• W2922483141 cites W2102472095 @default.
• W2922483141 cites W2103724228 @default.
• W2922483141 cites W2104537148 @default.
• W2922483141 cites W2105679485 @default.
• W2922483141 cites W2109550280 @default.
• W2922483141 cites W2115807816 @default.
• W2922483141 cites W2124311711 @default.
• W2922483141 cites W2127826417 @default.
• W2922483141 cites W2133613657 @default.
• W2922483141 cites W2134629862 @default.
• W2922483141 cites W2140681541 @default.
• W2922483141 cites W2142298371 @default.
• W2922483141 cites W2144480059 @default.
• W2922483141 cites W2146511995 @default.
• W2922483141 cites W2147422529 @default.
• W2922483141 cites W2147526306 @default.
• W2922483141 cites W2152475228 @default.
• W2922483141 cites W2155606878 @default.
• W2922483141 cites W2161044764 @default.
• W2922483141 cites W2162143298 @default.
• W2922483141 cites W2163569756 @default.
• W2922483141 cites W2165947442 @default.
• W2922483141 cites W2178935594 @default.
• W2922483141 cites W2215375911 @default.
• W2922483141 cites W2268443037 @default.
• W2922483141 cites W2299490193 @default.
• W2922483141 cites W2324257742 @default.
• W2922483141 cites W2398430375 @default.
• W2922483141 cites W2466042115 @default.
• W2922483141 cites W2468004912 @default.
• W2922483141 cites W2514730674 @default.
• W2922483141 cites W2517026908 @default.
• W2922483141 cites W2543970794 @default.
• W2922483141 cites W2560103880 @default.
• W2922483141 cites W2560261877 @default.
• W2922483141 cites W2570018941 @default.
• W2922483141 cites W2575620894 @default.
• W2922483141 cites W2601663960 @default.
• W2922483141 cites W2614910036 @default.
• W2922483141 cites W2738584174 @default.
• W2922483141 cites W2766847129 @default.
• W2922483141 cites W2804008698 @default.
• W2922483141 cites W2915737634 @default.
• W2922483141 cites W3152046499 @default.
• W2922483141 doi "https://doi.org/10.1186/s12864-019-5495-6" @default.
• W2922483141 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6379932" @default.
• W2922483141 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30777008" @default.
• W2922483141 hasPublicationYear "2019" @default.
• W2922483141 type Work @default.
• W2922483141 sameAs 2922483141 @default.
• W2922483141 citedByCount "13" @default.
• W2922483141 countsByYear W29224831412020 @default.

• next