Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922502010> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2922502010 endingPage "338" @default.
- W2922502010 startingPage "330" @default.
- W2922502010 abstract "Objectives Tertiary lymphoid organs are formed at sites of chronic inflammation and are thought to contribute to the immune response. Here, we aimed to characterize the structure and function of tertiary lymphoid organs in a model of murine kidney allotransplant to understand their role in alloimmunity. Materials and methods We transplanted 4 C57BL/6 mouse kidneys (isograft group) and 17 DBA/2 mouse kidneys into C57BL/6 mouse recipients. Three DBA/2-to-C57BL/6 transplant mice that rejected their grafts acutely (before 10 days posttransplant) were excluded from the study. The 14 surviving DAB2 grafts were retrieved at day 45 posttransplant and evaluated histologically. The presence of antibody-secreting cells and circulating levels of donor-specific antibodies were also evaluated. Results We found that tertiary lymphoid organs can be associated with a beneficial response in a kidney allotransplant model. Characterization of B-cell subsets within tertiary lymphoid organs in mouse kidney allografts revealed naive, plasma, and memory B cells, which were mostly grouped within or in close proximity of tertiary lymphoid organs. Staining for intracellular immunoglobulin G showed that many of the B cells within tertiary lymphoid organs were capable of producing antibodies. Although allospecific antibodies were found in the serum of recipient mice and were deposited in the transplanted kidneys, graft function was not affected in this model. Conclusions B cells within tertiary lymphoid organs are functional and contribute to the humoral arm of the alloresponse. However, tertiary lymphoid organs are not necessarily associated with graft rejection, suggesting that protective mechanisms are at play." @default.
- W2922502010 created "2019-03-22" @default.
- W2922502010 creator A5003333307 @default.
- W2922502010 creator A5013922510 @default.
- W2922502010 creator A5015981980 @default.
- W2922502010 creator A5043218129 @default.
- W2922502010 creator A5083303153 @default.
- W2922502010 date "2019-05-28" @default.
- W2922502010 modified "2023-09-25" @default.
- W2922502010 title "Characterizing the B-Cell and Humoral Response in Tertiary Lymphoid Organs in Kidney Allografts" @default.
- W2922502010 cites W1496296841 @default.
- W2922502010 cites W1507358916 @default.
- W2922502010 cites W1608541985 @default.
- W2922502010 cites W1951741511 @default.
- W2922502010 cites W1968532588 @default.
- W2922502010 cites W1979718470 @default.
- W2922502010 cites W1997111251 @default.
- W2922502010 cites W1998271677 @default.
- W2922502010 cites W1999260605 @default.
- W2922502010 cites W2012407667 @default.
- W2922502010 cites W2025307441 @default.
- W2922502010 cites W2044521216 @default.
- W2922502010 cites W2046637170 @default.
- W2922502010 cites W2047225646 @default.
- W2922502010 cites W2053458227 @default.
- W2922502010 cites W2056389041 @default.
- W2922502010 cites W2056556444 @default.
- W2922502010 cites W2058456826 @default.
- W2922502010 cites W2078237676 @default.
- W2922502010 cites W2099385262 @default.
- W2922502010 cites W2106347651 @default.
- W2922502010 cites W2111355146 @default.
- W2922502010 cites W2137442990 @default.
- W2922502010 cites W2143367304 @default.
- W2922502010 cites W2150661866 @default.
- W2922502010 cites W2167318411 @default.
- W2922502010 cites W2173879850 @default.
- W2922502010 cites W2239154376 @default.
- W2922502010 doi "https://doi.org/10.6002/ect.2017.0261" @default.
- W2922502010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30880652" @default.
- W2922502010 hasPublicationYear "2019" @default.
- W2922502010 type Work @default.
- W2922502010 sameAs 2922502010 @default.
- W2922502010 citedByCount "4" @default.
- W2922502010 countsByYear W29225020102020 @default.
- W2922502010 countsByYear W29225020102021 @default.
- W2922502010 countsByYear W29225020102023 @default.
- W2922502010 crossrefType "journal-article" @default.
- W2922502010 hasAuthorship W2922502010A5003333307 @default.
- W2922502010 hasAuthorship W2922502010A5013922510 @default.
- W2922502010 hasAuthorship W2922502010A5015981980 @default.
- W2922502010 hasAuthorship W2922502010A5043218129 @default.
- W2922502010 hasAuthorship W2922502010A5083303153 @default.
- W2922502010 hasConcept C126322002 @default.
- W2922502010 hasConcept C142724271 @default.
- W2922502010 hasConcept C181152851 @default.
- W2922502010 hasConcept C203014093 @default.
- W2922502010 hasConcept C2780091579 @default.
- W2922502010 hasConcept C71924100 @default.
- W2922502010 hasConceptScore W2922502010C126322002 @default.
- W2922502010 hasConceptScore W2922502010C142724271 @default.
- W2922502010 hasConceptScore W2922502010C181152851 @default.
- W2922502010 hasConceptScore W2922502010C203014093 @default.
- W2922502010 hasConceptScore W2922502010C2780091579 @default.
- W2922502010 hasConceptScore W2922502010C71924100 @default.
- W2922502010 hasIssue "3" @default.
- W2922502010 hasLocation W29225020101 @default.
- W2922502010 hasOpenAccess W2922502010 @default.
- W2922502010 hasPrimaryLocation W29225020101 @default.
- W2922502010 hasRelatedWork W1995871134 @default.
- W2922502010 hasRelatedWork W2009548384 @default.
- W2922502010 hasRelatedWork W2020347089 @default.
- W2922502010 hasRelatedWork W2094664811 @default.
- W2922502010 hasRelatedWork W2096890189 @default.
- W2922502010 hasRelatedWork W2104354137 @default.
- W2922502010 hasRelatedWork W2111533798 @default.
- W2922502010 hasRelatedWork W2112227821 @default.
- W2922502010 hasRelatedWork W2244617787 @default.
- W2922502010 hasRelatedWork W2336868671 @default.
- W2922502010 hasVolume "17" @default.
- W2922502010 isParatext "false" @default.
- W2922502010 isRetracted "false" @default.
- W2922502010 magId "2922502010" @default.
- W2922502010 workType "article" @default.