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- W2922520373 abstract "Introduction: Severe hypoglycemia is common among those with type 1 diabetes (T1D). Hypoglycemia unawareness (HU) in T1D increases the risk of severe hypoglycemia more than five-fold. Prior work has established an association between severe hypoglycemia and impaired cognition. However, it is unknown if HU is associated with impaired cognition. Hypothesis: We hypothesized that HU would be associated with impaired cognition in a large cohort of older adults with T1D. Methods: We examined the association between HU and cognitive function using baseline data collected on 544 older adults with T1D from the Study of Longevity in Diabetes (SOLID). Self-reported HU was assessed using the 8-item Clarke Hypoglycemia Awareness Questionnaire, which captures frequency of hypoglycemia and awareness of symptoms. Participants with responses indicating ‘reduced awareness’ on ≥4 of the 8 items were categorized as having reduced awareness. Cognitive tests assessed four cognitive domains identified via factor analysis (language, executive function, episodic memory, attention). All cognitive test scores were standardized. Using generalized linear regression, we examined the association between HU and cognition on each of the four cognitive domains and on global cognition (average of scores on the 4 domains) in models adjusted for age and age, sex, education, race/ethnicity, and diabetes duration. Results: Overall, 27% of participants (n=149) had reduced hypoglycemia awareness. In fully adjusted models, compared to those with normal awareness, those with reduced hypoglycemia awareness had significantly lower scores on measures of language and global cognition; however, executive function, episodic memory and simple attention did not differ by HU status. Conclusions: Our results suggest that, among older adults with type 1 diabetes, HU may be associated with poorer cognition, specifically through language-related processes." @default.
- W2922520373 created "2019-03-22" @default.
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- W2922520373 date "2019-03-05" @default.
- W2922520373 modified "2023-09-26" @default.
- W2922520373 title "Abstract P011: Hypoglycemia Unawareness is Associated With Impaired Cognition Among Older Adults With Type 1 Diabetes: the Study of Longevity in Diabetes" @default.
- W2922520373 doi "https://doi.org/10.1161/circ.139.suppl_1.p011" @default.
- W2922520373 hasPublicationYear "2019" @default.
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