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- W2922622777 abstract "BACKGROUND: Acute pancreatitis is a severe and frequently lethal disorder which occurs suddenly and develops rapidly. Acute pancreatitis is usually accompanied with systemic inflammatory cascades and microcirculatory disturbance. Microcirculatory disturbance is a trigger factor in the development of Acute pancreatitis, and plays a key role in the development of multiple organ dysfunction syndrome or multiple organ failure (MODS/MOF) The aim of the study is to look for the role of low molecular weight heparin (LMWH) IN treatment of pancreatitis which improves microcirculationPATIENTS AND METHODS:Our study included 100 patients, 50 in each group GROUP : A patients will undergo conventional therapy that includes management of shock; maintenance of water and electrolytes balance, fasting, gastrointestinal decompression, administration of pancreatic enzymes inhibitor (octreotide), antibiotics (cephalosporins and metronidazole) and oral manganese sulfate and symptomatic treatment.GROUP : B patients: The treatment included following the methods used in GROUP A patients, plus administering LMWH at 100 micro gram /kg per day subcutaneous injection starting from the admission day and continuing for 7 days.The APACHE II score was compared in both groups at the time of admission and after 7 a days of treatment.RESULTS:The results showed that the decline in APACHE-II scores in the observation group was larger than that in the control group and lower values than those in CONTROL group (p < 0.05–0.01). There is a significant benefit in terms of mean hospital stay, morbidity and mortality rate in LMWH group.CONCLUSION:LMWH can enhance the effect of conventional treatment for acute pancreatitis, and can markedly decrease the mortality of acute pancreatitis. LMWH is a simple, safe, economic and effective method for treatment of acute pancreatitis." @default.
- W2922622777 created "2019-04-01" @default.
- W2922622777 creator A5058556818 @default.
- W2922622777 date "2018-05-01" @default.
- W2922622777 modified "2023-09-26" @default.
- W2922622777 title "Role of low molecular weight heparin in treatment of acute pancreatitis" @default.
- W2922622777 hasPublicationYear "2018" @default.
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