Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922634558> ?p ?o ?g. }
- W2922634558 abstract "Tuberculosis (TB) is a major global public health problem causing significant mortality and morbidity. In addition to ~10.4 million cases of active TB annually, it is estimated that about two billion people are latently infected with Mycobacterium tuberculosis (Mtb), the causative agent of TB. Reactivation of latent Mtb infection is the leading cause of death in patients with immunodeficiency virus (HIV) infection. The low efficiency of the only licensed anti-TB vaccine, Bacille Calmette-Guérin (BCG) to reduce pulmonary TB in adults contributes to this problem. Here we investigated if vaccination with conventional BCG or the genetically modified experimental BCGΔBCG1419c strain can prevent reactivation of latent lymphatic TB in a mouse model of induced reactivation, following the depletion of CD4+ T cells, as it occurs in HIV+ individuals. Vaccination with conventional BCG or BCGΔBCG1419c prevented reactivation of Mtb from the infected lymph node and the systemic spread of Mtb to spleen and lung. Prevention of reactivation was independent of vaccination route and was accompanied by reduced levels of circulating inflammatory cytokines and the absence of lung pathology. Our results demonstrate that vaccine-induced CD4+ T cells are not essential to prevent reactivation of latent lymphatic murine TB, and highlight the need to better understand how non-CD4+ immune cell populations participate in protective immune responses to control latent TB." @default.
- W2922634558 created "2019-04-01" @default.
- W2922634558 creator A5013742202 @default.
- W2922634558 creator A5021003953 @default.
- W2922634558 creator A5027632335 @default.
- W2922634558 creator A5036755500 @default.
- W2922634558 creator A5060599041 @default.
- W2922634558 creator A5073530719 @default.
- W2922634558 date "2019-03-21" @default.
- W2922634558 modified "2023-09-25" @default.
- W2922634558 title "BCG Vaccination Prevents Reactivation of Latent Lymphatic Murine Tuberculosis Independently of CD4+ T Cells" @default.
- W2922634558 cites W1891754006 @default.
- W2922634558 cites W1967051290 @default.
- W2922634558 cites W1974295132 @default.
- W2922634558 cites W1979194104 @default.
- W2922634558 cites W1981096151 @default.
- W2922634558 cites W1991801598 @default.
- W2922634558 cites W2008688858 @default.
- W2922634558 cites W2010318115 @default.
- W2922634558 cites W2010429088 @default.
- W2922634558 cites W2017173637 @default.
- W2922634558 cites W2025430970 @default.
- W2922634558 cites W2032186491 @default.
- W2922634558 cites W2058635567 @default.
- W2922634558 cites W2058969608 @default.
- W2922634558 cites W2061765078 @default.
- W2922634558 cites W2075477269 @default.
- W2922634558 cites W2083006524 @default.
- W2922634558 cites W2086114953 @default.
- W2922634558 cites W2097008213 @default.
- W2922634558 cites W2097403005 @default.
- W2922634558 cites W2104557844 @default.
- W2922634558 cites W2116619718 @default.
- W2922634558 cites W2132999784 @default.
- W2922634558 cites W2133457373 @default.
- W2922634558 cites W2133611371 @default.
- W2922634558 cites W2135746704 @default.
- W2922634558 cites W2137633461 @default.
- W2922634558 cites W2139398845 @default.
- W2922634558 cites W2162615775 @default.
- W2922634558 cites W2164309428 @default.
- W2922634558 cites W2164423040 @default.
- W2922634558 cites W2181978203 @default.
- W2922634558 cites W2269375097 @default.
- W2922634558 cites W2277861006 @default.
- W2922634558 cites W2343808808 @default.
- W2922634558 cites W2437228747 @default.
- W2922634558 cites W2467308937 @default.
- W2922634558 cites W2518123420 @default.
- W2922634558 cites W2520295082 @default.
- W2922634558 cites W2521361619 @default.
- W2922634558 cites W2531189450 @default.
- W2922634558 cites W2533230523 @default.
- W2922634558 cites W2549771086 @default.
- W2922634558 cites W2568769321 @default.
- W2922634558 cites W2597394874 @default.
- W2922634558 cites W2604792316 @default.
- W2922634558 cites W2608290060 @default.
- W2922634558 cites W2618718964 @default.
- W2922634558 cites W2734641426 @default.
- W2922634558 cites W2737312556 @default.
- W2922634558 cites W2755564631 @default.
- W2922634558 cites W2756158128 @default.
- W2922634558 cites W2763033987 @default.
- W2922634558 cites W2773156503 @default.
- W2922634558 cites W2783711120 @default.
- W2922634558 cites W2786068252 @default.
- W2922634558 cites W2790898162 @default.
- W2922634558 cites W2791315694 @default.
- W2922634558 cites W2791882709 @default.
- W2922634558 cites W2792935975 @default.
- W2922634558 cites W2797540534 @default.
- W2922634558 cites W2803989671 @default.
- W2922634558 cites W2808373354 @default.
- W2922634558 cites W2892057890 @default.
- W2922634558 cites W2896064560 @default.
- W2922634558 cites W2899307752 @default.
- W2922634558 cites W2952724804 @default.
- W2922634558 cites W4313333757 @default.
- W2922634558 doi "https://doi.org/10.3389/fimmu.2019.00532" @default.
- W2922634558 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6437071" @default.
- W2922634558 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30949177" @default.
- W2922634558 hasPublicationYear "2019" @default.
- W2922634558 type Work @default.
- W2922634558 sameAs 2922634558 @default.
- W2922634558 citedByCount "14" @default.
- W2922634558 countsByYear W29226345582019 @default.
- W2922634558 countsByYear W29226345582020 @default.
- W2922634558 countsByYear W29226345582021 @default.
- W2922634558 countsByYear W29226345582022 @default.
- W2922634558 countsByYear W29226345582023 @default.
- W2922634558 crossrefType "journal-article" @default.
- W2922634558 hasAuthorship W2922634558A5013742202 @default.
- W2922634558 hasAuthorship W2922634558A5021003953 @default.
- W2922634558 hasAuthorship W2922634558A5027632335 @default.
- W2922634558 hasAuthorship W2922634558A5036755500 @default.
- W2922634558 hasAuthorship W2922634558A5060599041 @default.
- W2922634558 hasAuthorship W2922634558A5073530719 @default.
- W2922634558 hasBestOaLocation W29226345581 @default.
- W2922634558 hasConcept C142724271 @default.