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• W2922641378 endingPage "8069" @default.
• W2922641378 startingPage "8060" @default.
• W2922641378 abstract "HISTONE MONOUBIQUITINATION1 (HUB1) and its paralog HUB2 act in a conserved heterotetrameric complex in the chromatin-mediated transcriptional modulation of developmental programs, such as flowering time, dormancy, and the circadian clock. The KHD1 and SPEN3 proteins were identified as interactors of the HUB1 and HUB2 proteins with in vitro RNA-binding activity. Mutants in SPEN3 and KHD1 had reduced rosette and leaf areas. Strikingly, in spen3 mutants, the flowering time was slightly, but significantly, delayed, as opposed to the early flowering time in the hub1-4 mutant. The mutant phenotypes in biomass and flowering time suggested a deregulation of their respective regulatory genes CIRCADIAN CLOCK-ASSOCIATED1 ( CCA1 ) and FLOWERING LOCUS C ( FLC ) that are known targets of the HUB1-mediated histone H2B monoubiquitination (H2Bub). Indeed, in the spen3-1 and hub1-4 mutants, the circadian clock period was shortened as observed by luciferase reporter assays, the levels of the CCA1 α and CCA1 β splice forms were altered, and the CCA1 expression and H2Bub levels were reduced. In the spen3-1 mutant, the delay in flowering time was correlated with an enhanced FLC expression, possibly due to an increased distal versus proximal ratio of its antisense COOLAIR transcript. Together with transcriptomic and double-mutant analyses, our data revealed that the HUB1 interaction with SPEN3 links H2Bub during transcript elongation with pre-mRNA processing at CCA1 . Furthermore, the presence of an intact HUB1 at the FLC is required for SPEN3 function in the formation of the FLC -derived antisense COOLAIR transcripts." @default.
• W2922641378 created "2019-04-01" @default.
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• W2922641378 date "2019-03-28" @default.
• W2922641378 modified "2023-10-16" @default.
• W2922641378 title "Histone 2B monoubiquitination complex integrates transcript elongation with RNA processing at circadian clock and flowering regulators" @default.
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• W2922641378 doi "https://doi.org/10.1073/pnas.1806541116" @default.
• W2922641378 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6475378" @default.
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• W2922641378 hasPublicationYear "2019" @default.
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