FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922642854> ?p ?o ?g. }

• W2922642854 endingPage "673" @default.
• W2922642854 startingPage "667" @default.
• W2922642854 abstract "Abstract Background People living with human immunodeficiency virus (HIV) infection have higher risk for chronic kidney disease (CKD), defined by a reduced estimated glomerular filtration rate (eGFR). Previous studies have implicated epigenetic changes related to CKD; however, the mechanism of HIV-related CKD has not been thoroughly investigated. Methods We conducted an epigenome-wide association study of eGFR among 567 HIV-positive and 117 HIV-negative male participants in the Veterans Aging Cohort Study to identify epigenetic signatures of kidney function. Results By surveying more than 400 000 cytosine guanine dinucleotide (CpG) sites measured from peripheral blood mononuclear cells, we identified 15 sites that were significantly associated with eGFR (false discovery rate Q value &lt; 0.05) among HIV-positive participants. The most significant CpG sites, located at MAD1L1, TSNARE1/BAI1, and LTV1, were all negatively associated with eGFR (cg06329547, P = 5.25 × 10–9; cg23281907, P = 1.37 × 10–8; cg18368637, P = 5.17 × 10–8). We also replicated previously reported eGFR-associated CpG sites including cg17944885 (P = 2.5 × 10–5) located between ZNF788 and ZNF20 on chromosome 19 in the pooled population. Conclusions In this study we uncovered novel epigenetic associations with kidney function among people living with HIV and suggest potential epigenetic mechanisms linked with HIV-related CKD risk." @default.
• W2922642854 created "2019-04-01" @default.
• W2922642854 creator A5003111624 @default.
• W2922642854 creator A5025733523 @default.
• W2922642854 creator A5026540715 @default.
• W2922642854 creator A5039284931 @default.
• W2922642854 creator A5049322594 @default.
• W2922642854 creator A5055309934 @default.
• W2922642854 creator A5075575064 @default.
• W2922642854 creator A5081148959 @default.
• W2922642854 creator A5082160146 @default.
• W2922642854 creator A5084970543 @default.
• W2922642854 creator A5088648714 @default.
• W2922642854 date "2019-03-20" @default.
• W2922642854 modified "2023-10-13" @default.
• W2922642854 title "Epigenetic Associations With Estimated Glomerular Filtration Rate Among Men With Human Immunodeficiency Virus Infection" @default.
• W2922642854 cites W1692222554 @default.
• W2922642854 cites W1970528899 @default.
• W2922642854 cites W1973331597 @default.
• W2922642854 cites W1974047233 @default.
• W2922642854 cites W1982756878 @default.
• W2922642854 cites W2006207922 @default.
• W2922642854 cites W2023491353 @default.
• W2922642854 cites W2029028259 @default.
• W2922642854 cites W2039426604 @default.
• W2922642854 cites W2039432541 @default.
• W2922642854 cites W2051038826 @default.
• W2922642854 cites W2051285263 @default.
• W2922642854 cites W2052629634 @default.
• W2922642854 cites W2053102671 @default.
• W2922642854 cites W2080152031 @default.
• W2922642854 cites W2083225704 @default.
• W2922642854 cites W2084270956 @default.
• W2922642854 cites W2098238559 @default.
• W2922642854 cites W2099437253 @default.
• W2922642854 cites W2105314711 @default.
• W2922642854 cites W2110717475 @default.
• W2922642854 cites W2126684705 @default.
• W2922642854 cites W2129926563 @default.
• W2922642854 cites W2137608879 @default.
• W2922642854 cites W2155965977 @default.
• W2922642854 cites W2163887613 @default.
• W2922642854 cites W2254194192 @default.
• W2922642854 cites W2278753145 @default.
• W2922642854 cites W2325094346 @default.
• W2922642854 cites W2560074970 @default.
• W2922642854 cites W2576668239 @default.
• W2922642854 cites W2766367869 @default.
• W2922642854 cites W2766407607 @default.
• W2922642854 cites W2773911224 @default.
• W2922642854 cites W2909735706 @default.
• W2922642854 doi "https://doi.org/10.1093/cid/ciz240" @default.
• W2922642854 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7319269" @default.
• W2922642854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30893429" @default.
• W2922642854 hasPublicationYear "2019" @default.
• W2922642854 type Work @default.
• W2922642854 sameAs 2922642854 @default.
• W2922642854 citedByCount "21" @default.
• W2922642854 countsByYear W29226428542019 @default.
• W2922642854 countsByYear W29226428542020 @default.
• W2922642854 countsByYear W29226428542021 @default.
• W2922642854 countsByYear W29226428542022 @default.
• W2922642854 countsByYear W29226428542023 @default.
• W2922642854 crossrefType "journal-article" @default.
• W2922642854 hasAuthorship W2922642854A5003111624 @default.
• W2922642854 hasAuthorship W2922642854A5025733523 @default.
• W2922642854 hasAuthorship W2922642854A5026540715 @default.
• W2922642854 hasAuthorship W2922642854A5039284931 @default.
• W2922642854 hasAuthorship W2922642854A5049322594 @default.
• W2922642854 hasAuthorship W2922642854A5055309934 @default.
• W2922642854 hasAuthorship W2922642854A5075575064 @default.
• W2922642854 hasAuthorship W2922642854A5081148959 @default.
• W2922642854 hasAuthorship W2922642854A5082160146 @default.
• W2922642854 hasAuthorship W2922642854A5084970543 @default.
• W2922642854 hasAuthorship W2922642854A5088648714 @default.
• W2922642854 hasBestOaLocation W29226428542 @default.
• W2922642854 hasConcept C104317684 @default.
• W2922642854 hasConcept C117717151 @default.
• W2922642854 hasConcept C126322002 @default.
• W2922642854 hasConcept C140173407 @default.
• W2922642854 hasConcept C150194340 @default.
• W2922642854 hasConcept C159641895 @default.
• W2922642854 hasConcept C190727270 @default.
• W2922642854 hasConcept C203014093 @default.
• W2922642854 hasConcept C2775921022 @default.
• W2922642854 hasConcept C2778653478 @default.
• W2922642854 hasConcept C2908647359 @default.
• W2922642854 hasConcept C41091548 @default.
• W2922642854 hasConcept C54355233 @default.
• W2922642854 hasConcept C71924100 @default.
• W2922642854 hasConcept C86803240 @default.
• W2922642854 hasConcept C99454951 @default.
• W2922642854 hasConceptScore W2922642854C104317684 @default.
• W2922642854 hasConceptScore W2922642854C117717151 @default.
• W2922642854 hasConceptScore W2922642854C126322002 @default.
• W2922642854 hasConceptScore W2922642854C140173407 @default.
• W2922642854 hasConceptScore W2922642854C150194340 @default.
• W2922642854 hasConceptScore W2922642854C159641895 @default.

• next