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• W2922731999 abstract "Abstract Adolescents show greater and/or more prolonged activation of the hypothalamic‐pituitary‐adrenal axis in response to stressors than adults, although the basis for such an age difference is not understood. We investigated developmental shifts in the regulation of HPA function by testosterone using androgen replacement in orchiectomised ( OCX ) pre‐pubertal and post‐pubertal adolescent rats and in adults, as well as using inhibitors of testosterone synthesis in non‐operated rats. The expected dampening effect of testosterone in adult OCX rats did not meet statistical significance in all of the three experiments. Nevertheless, in each, adolescents had higher post‐stress concentrations of corticosterone compared to adults despite similar concentrations of testosterone. The effect of testosterone was in the opposite direction in post‐pubertal adolescents compared to that in adults, with testosterone replacement leading to increased rather than lower corticosterone concentration. Testosterone replacement decreased arginine vasopressin and corticotrophin‐releasing hormone immune‐reactive cell counts in the paraventricular nucleus at all ages. In a fourth experiment, we provide evidence that the basis of the age difference in corticosterone release is because of a greater conversion of testosterone to oestradiol in adolescents and a greater conversion of testosterone to dihydrotestosterone in adults: aromatase inhibition had little effect in adults and attenuated the age difference by decreasing stress‐induced corticosterone release in adolescents. By contrast, 5α‐reductase inhibition or an androgen receptor antagonist had little effect in adolescents and attenuated the age difference by increasing stress‐induced corticosterone release in adults. In the adrenal gland, adolescents had reduced 5α‐reductase and androgen receptor gene expression. There also were age differences in the regulation of hypothalamic mRNA expression of androgen receptors, oestrogen receptors and aromatase by testosterone. In sum, the results suggest that developmental shifts in the synthesis of testosterone and the regulation of gene expression are factors with respect to age differences in corticosterone release in response to stressors." @default.
• W2922731999 created "2019-04-01" @default.
• W2922731999 creator A5022543459 @default.
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• W2922731999 creator A5061826523 @default.
• W2922731999 date "2019-04-17" @default.
• W2922731999 modified "2023-10-16" @default.
• W2922731999 title "Age‐dependent regulation by androgens of gene expression in the anterior hypothalamus and stress‐induced release of adrenal hormones in adolescent and adult male rats" @default.
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• W2922731999 doi "https://doi.org/10.1111/jne.12714" @default.
• W2922731999 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30912177" @default.
• W2922731999 hasPublicationYear "2019" @default.
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