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- W2922752562 abstract "Alimentary mucositis is a severe dose limiting side effect of chemotherapy and radiotherapy. Mucin expression and secretion are associated with mucositis. This article aims to review current studies involving mucin and mucositis.Mucins have been shown to alter mucositis severity and key targets associated with mucositis. First, interventions increasing mucin content has been associated with reduce damage associated with mucositis. Second, mucins have also been shown to protect microbiota from radiation-induced damage. Finally, mucins have also been shown to be involved in lumen epithelial barrier interactions altering signalling for cell proliferation, motility, and the inhibition of apoptosis.The current studies suggest that mucin expression prior to and during mucositis may be very important in reducing the severity of mucositis and further research into the area is warranted." @default.
- W2922752562 created "2019-04-01" @default.
- W2922752562 creator A5025877363 @default.
- W2922752562 date "2019-06-01" @default.
- W2922752562 modified "2023-09-26" @default.
- W2922752562 title "The role of mucins in mucositis" @default.
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- W2922752562 doi "https://doi.org/10.1097/spc.0000000000000423" @default.
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