Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922762783> ?p ?o ?g. }
- W2922762783 endingPage "64" @default.
- W2922762783 startingPage "53" @default.
- W2922762783 abstract "Sulfate-based lipids (SL) have been proposed as players in inflammation, immunity and infection. In spite of the many biochemical processes linked to SL, analysis on this class of lipids has only focused on specific SL sub-classes in individual fluids or cells leaving a range of additional SL in other biological samples unaccounted for. This study describes the mass spectrometry screening of SL in lipid extracts of human fluids (saliva, plasma, urine, seminal fluid) and primary human cells (RBC, neutrophils, fibroblasts and skin epidermal) using targeted precursor ion scanning (PIS) approach. The PIS 97 mass spectra reveal a wide diversity of SL including steroid sulfates, sulfoglycolipids and other unidentified SL, as well as metabolites such as taurines, sulfated polyphenols and hypurate conjugates. Semi-quantification of SL revealed that plasma exhibited the highest content of SL whereas seminal fluid and epithelial cells contained the highest sulphur to phosphorous (S/P) ratio. The complexity of biofluids and cells sulfateome presented in this study highlight the importance of expanding the panel of synthetic sulfate-based lipid standards. Also, the heterogenous distribution of SL provides evidence for the interplay of sulfotransferases/sulfatases, opening new avenues for biomarker discovery in oral health, cardiovascular, fertility and dermatology research areas." @default.
- W2922762783 created "2019-04-01" @default.
- W2922762783 creator A5001343827 @default.
- W2922762783 creator A5007439444 @default.
- W2922762783 creator A5008183590 @default.
- W2922762783 creator A5034156967 @default.
- W2922762783 creator A5037240373 @default.
- W2922762783 creator A5038159404 @default.
- W2922762783 creator A5040791868 @default.
- W2922762783 creator A5060502597 @default.
- W2922762783 creator A5072119581 @default.
- W2922762783 creator A5075468536 @default.
- W2922762783 date "2019-07-01" @default.
- W2922762783 modified "2023-10-03" @default.
- W2922762783 title "Sulfate-based lipids: Analysis of healthy human fluids and cell extracts" @default.
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