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- W2922763339 abstract "To investigate the role of 18F-FDG positron emission tomography/computed tomography (PET/CT) in detection of recurrence in ovarian cancer patients with increased CA-125 levels.Fifty-two patients (30-80 years old, mean: 58.5±10.6 years) who had been histopathologically diagnosed with ovarian cancer, underwent 18F-FDG PET/CT imaging for re-staging due to elevation of CA-125 levels were included in this retrospective study. 18F-FDG PET/CT findings were compared with histopathological, radiological and clinical follow-up results.CA-125 levels ranged between 35.2-2740 U/mL (N: 0-35 U/mL). Recurrent disease was detected in 45 of 52 patients on PET/CT imaging. There were three false negative and one false positive result. In addition to abdominal and pelvic lesions, 14 distant metastatic lesions (brain, lung, liver and bone metastasis) were identified correctly on PET/CT imaging. Sensitivity, specificity, positive and negative predictive value and accuracy of 18F-FDG PET/CT were calculated as 94%, 75%, 98%, 50% and 96%, respectively.18F-FDG PET/CT is a useful imaging method that can be used in detection of ovarian cancer recurrence in patients with elevated CA-125 levels. Since this modality offers whole body imaging, distant metastases could be detected in addition to abdominal and pelvic lesions thus contributing to patient management.Bu çalışmanın amacı, serum CA-125 düzeylerinde artış olan over kanserli hastalarda rekürrens saptamada 18F-FDG pozitron emisyon tomografi/bilgisayarlı tomografinin (PET/BT) rolünü araştırmaktır.Bu retrospektif çalışmaya histopatolojik olarak over kanseri tanısı almış, CA-125 düzeylerinde artış nedeniyle yeniden evreleme amacıyla 18F-FDG PET/BT yapılan 52 hasta (30-80 yaş, ortalama: 58,5±10,6 yaş) dahil edildi. 18F-FDG PET/BT bulguları histopatolojik bulgular veya radyolojik ve klinik izlem sonuçlarıyla karşılaştırıldıCA-125 düzeyleri 35,2-2740 U/mL (N: 0-35 U/mL) aralığındaydı. PET/BT görüntülerinde rekürren hastalık 52 hastanın 45’inde gösterildi. Üç yanlış negatif, bir yanlış pozitif sonuç elde edildi. Abdominal ve pelvik lezyonlara ilave olarak 14 uzak metastaz (beyin, akciğer, karaciğer ve kemik metastazı) PET/BT ile doğru olarak gösterildi. Duyarlılık, özgüllük, pozitif ve negatif öngörü değeri ve doğruluk sırasıyla %94, %75, %98, %50 ve %96 idi.18F-FDG PET/BT, serum CA-125 düzeylerinde artış olan over kanserli hastalarda rekürrens saptamada kullanılabilecek yararlı bir yöntemdir. Tüm vücut görüntüleme yöntemi olması nedeniyle abdominal ve pelvik lezyonların yanında uzak metastazları da saptayarak bu hastaların izlemine katkıda bulunabilir." @default.
- W2922763339 created "2019-04-01" @default.
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- W2922763339 date "2019-02-01" @default.
- W2922763339 modified "2023-10-13" @default.
- W2922763339 title "The Role of <sup>18</sup>F-FDG PET/CT in Detecting Ovarian Cancer Recurrence in Patients with Elevated CA-125 Levels" @default.
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- W2922763339 doi "https://doi.org/10.4274/mirt.galenos.2018.00710" @default.
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