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- W2922764110 abstract "Significance Pancreatic cancer is notoriously treatment resistant. These tumors rely on lysosome-dependent recycling pathways to generate substrates for metabolism, which are inhibited by chloroquine (CQ) and its derivatives. However, clinical efficacy of CQ as a monotherapy or combined with standard-of-care regimens has been limited. Using an unbiased kinome screen, we identify replication stress as an induced vulnerability of CQ due to impaired de novo nucleotide biosynthesis and find that combination treatment with CQ and a replication stress response inhibitor is synthetically lethal in pancreatic cancer." @default.
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- W2922764110 date "2019-03-20" @default.
- W2922764110 modified "2023-10-16" @default.
- W2922764110 title "Lysosome inhibition sensitizes pancreatic cancer to replication stress by aspartate depletion" @default.
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- W2922764110 doi "https://doi.org/10.1073/pnas.1812410116" @default.
- W2922764110 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6452719" @default.
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