Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922780360> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2922780360 abstract "Group 2 innate lymphoid cells (ILC2s) play an important role in the initiation of type-2 immune responses. Numerous targets have been identified that may activate or repress ILC2 function, though few negative regulatory feedback pathways induced upon activation have been shown to be operative in ILC2s. Here we demonstrate that loss of ADAM17 from ILC2s results in a selective defect in IL-33 responsiveness, but not IL-25 responsiveness. We find that IL1R2 is significantly upregulated at both the transcript and protein level in IL-33 activated ILC2s. We are also able to demonstrate that ADAM17 regulates IL1R2 levels on ILC2s in both a constitutive and activation induced manner. Additionally, IL1R2+ ILC2s, a unique subset of ILC2s, have decreased Il5 and Il13 transcripts following IL-33 stimulation. Overall, these data suggest that the expression of IL1R2 may act as an activation-induced negative regulatory feedback mechanism to decrease ILC2 responsiveness to IL-33." @default.
- W2922780360 created "2019-04-01" @default.
- W2922780360 creator A5027338850 @default.
- W2922780360 creator A5049658773 @default.
- W2922780360 creator A5068767093 @default.
- W2922780360 date "2019-05-01" @default.
- W2922780360 modified "2023-09-24" @default.
- W2922780360 title "A Disintegrin and Metalloproteinase 17 is required for ILC2 responses to IL-33" @default.
- W2922780360 cites W1488576485 @default.
- W2922780360 cites W1592394199 @default.
- W2922780360 cites W1964948273 @default.
- W2922780360 cites W1965971815 @default.
- W2922780360 cites W1967413976 @default.
- W2922780360 cites W1979315677 @default.
- W2922780360 cites W1995070836 @default.
- W2922780360 cites W2015437055 @default.
- W2922780360 cites W2031721046 @default.
- W2922780360 cites W2036842448 @default.
- W2922780360 cites W2047882259 @default.
- W2922780360 cites W2078136106 @default.
- W2922780360 cites W2091282297 @default.
- W2922780360 cites W2093498736 @default.
- W2922780360 cites W2101500685 @default.
- W2922780360 cites W2140206763 @default.
- W2922780360 cites W2155916024 @default.
- W2922780360 cites W2161033554 @default.
- W2922780360 cites W2165275387 @default.
- W2922780360 cites W2166623795 @default.
- W2922780360 cites W2300527575 @default.
- W2922780360 cites W2747616958 @default.
- W2922780360 cites W2782130265 @default.
- W2922780360 doi "https://doi.org/10.1016/j.bbrc.2019.03.120" @default.
- W2922780360 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6467721" @default.
- W2922780360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30926166" @default.
- W2922780360 hasPublicationYear "2019" @default.
- W2922780360 type Work @default.
- W2922780360 sameAs 2922780360 @default.
- W2922780360 citedByCount "5" @default.
- W2922780360 countsByYear W29227803602020 @default.
- W2922780360 countsByYear W29227803602021 @default.
- W2922780360 countsByYear W29227803602022 @default.
- W2922780360 crossrefType "journal-article" @default.
- W2922780360 hasAuthorship W2922780360A5027338850 @default.
- W2922780360 hasAuthorship W2922780360A5049658773 @default.
- W2922780360 hasAuthorship W2922780360A5068767093 @default.
- W2922780360 hasBestOaLocation W29227803602 @default.
- W2922780360 hasConcept C104317684 @default.
- W2922780360 hasConcept C119557319 @default.
- W2922780360 hasConcept C127561419 @default.
- W2922780360 hasConcept C134018914 @default.
- W2922780360 hasConcept C136449434 @default.
- W2922780360 hasConcept C14036430 @default.
- W2922780360 hasConcept C181901479 @default.
- W2922780360 hasConcept C185592680 @default.
- W2922780360 hasConcept C203014093 @default.
- W2922780360 hasConcept C24998067 @default.
- W2922780360 hasConcept C2778690821 @default.
- W2922780360 hasConcept C47742525 @default.
- W2922780360 hasConcept C55493867 @default.
- W2922780360 hasConcept C74172505 @default.
- W2922780360 hasConcept C86803240 @default.
- W2922780360 hasConcept C8891405 @default.
- W2922780360 hasConcept C95444343 @default.
- W2922780360 hasConceptScore W2922780360C104317684 @default.
- W2922780360 hasConceptScore W2922780360C119557319 @default.
- W2922780360 hasConceptScore W2922780360C127561419 @default.
- W2922780360 hasConceptScore W2922780360C134018914 @default.
- W2922780360 hasConceptScore W2922780360C136449434 @default.
- W2922780360 hasConceptScore W2922780360C14036430 @default.
- W2922780360 hasConceptScore W2922780360C181901479 @default.
- W2922780360 hasConceptScore W2922780360C185592680 @default.
- W2922780360 hasConceptScore W2922780360C203014093 @default.
- W2922780360 hasConceptScore W2922780360C24998067 @default.
- W2922780360 hasConceptScore W2922780360C2778690821 @default.
- W2922780360 hasConceptScore W2922780360C47742525 @default.
- W2922780360 hasConceptScore W2922780360C55493867 @default.
- W2922780360 hasConceptScore W2922780360C74172505 @default.
- W2922780360 hasConceptScore W2922780360C86803240 @default.
- W2922780360 hasConceptScore W2922780360C8891405 @default.
- W2922780360 hasConceptScore W2922780360C95444343 @default.
- W2922780360 hasLocation W29227803601 @default.
- W2922780360 hasLocation W29227803602 @default.
- W2922780360 hasLocation W29227803603 @default.
- W2922780360 hasLocation W29227803604 @default.
- W2922780360 hasOpenAccess W2922780360 @default.
- W2922780360 hasPrimaryLocation W29227803601 @default.
- W2922780360 hasRelatedWork W1524155111 @default.
- W2922780360 hasRelatedWork W1531317003 @default.
- W2922780360 hasRelatedWork W1556307916 @default.
- W2922780360 hasRelatedWork W1578291120 @default.
- W2922780360 hasRelatedWork W2103515427 @default.
- W2922780360 hasRelatedWork W2582591980 @default.
- W2922780360 hasRelatedWork W3136230949 @default.
- W2922780360 hasRelatedWork W3203432298 @default.
- W2922780360 hasRelatedWork W4206425682 @default.
- W2922780360 hasRelatedWork W4242298313 @default.
- W2922780360 isParatext "false" @default.
- W2922780360 isRetracted "false" @default.
- W2922780360 magId "2922780360" @default.
- W2922780360 workType "article" @default.