FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922791012> ?p ?o ?g. }

• W2922791012 endingPage "672" @default.
• W2922791012 startingPage "661" @default.
• W2922791012 abstract "The present study was designed to examine the therapeutic effects of Botulinum neurotoxin A (BoNT/A) on depression-like behaviors in mice and to explore the potential mechanisms. These results revealed that a single facial injection of BoNT/A induced a rapid and prolonged improvement of depression-like behaviors in naïve and space-restriction-stressed (SRS) mice, reflected by a decreased duration of immobility in behavioral despair tests. BoNT/A significantly increased the 5-hydroxytryptamine (5-HT) levels in several brain regions, including the hippocampus and hypothalamus, in SRS mice. BoNT/A increased the expression of the N-methyl-D-aspartate receptor subunits NR1 and NR2B in the hippocampus, which were significantly decreased in SRS mice. Furthermore, BoNT/A significantly increased the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus, hypothalamus, prefrontal cortex, and amygdala, which were decreased in SRS mice. Finally, BoNT/A transiently increased the levels of phosphorylated extracellular signal-regulated kinase (p-ERK) and cAMP-response element binding protein (p-CREB), which were suppressed in the hippocampus of SRS mice. Collectively, these results demonstrated that BoNT/A treatment has anti-depressant-like activity in mice, and this is associated with increased 5-HT levels and the activation of BDNF/ERK/CREB pathways in the hippocampus, supporting further investigation of BoNT/A therapy in depression." @default.
• W2922791012 created "2019-04-01" @default.
• W2922791012 creator A5004563088 @default.
• W2922791012 creator A5009613920 @default.
• W2922791012 creator A5028982370 @default.
• W2922791012 creator A5035282947 @default.
• W2922791012 creator A5043101749 @default.
• W2922791012 creator A5046775442 @default.
• W2922791012 creator A5059860203 @default.
• W2922791012 creator A5064955961 @default.
• W2922791012 creator A5067045315 @default.
• W2922791012 creator A5077265169 @default.
• W2922791012 creator A5090424198 @default.
• W2922791012 date "2019-03-21" @default.
• W2922791012 modified "2023-10-13" @default.
• W2922791012 title "Antidepressant-Like Action of Single Facial Injection of Botulinum Neurotoxin A is Associated with Augmented 5-HT Levels and BDNF/ERK/CREB Pathways in Mouse Brain" @default.
• W2922791012 cites W1098652179 @default.
• W2922791012 cites W1484469381 @default.
• W2922791012 cites W1510821208 @default.
• W2922791012 cites W1541025865 @default.
• W2922791012 cites W184284683 @default.
• W2922791012 cites W1941293036 @default.
• W2922791012 cites W1942357531 @default.
• W2922791012 cites W1969532190 @default.
• W2922791012 cites W1980374113 @default.
• W2922791012 cites W1981097208 @default.
• W2922791012 cites W1981764249 @default.
• W2922791012 cites W1983197762 @default.
• W2922791012 cites W2002765069 @default.
• W2922791012 cites W2005594217 @default.
• W2922791012 cites W2006864059 @default.
• W2922791012 cites W2030466283 @default.
• W2922791012 cites W2030991664 @default.
• W2922791012 cites W2034154112 @default.
• W2922791012 cites W2040649786 @default.
• W2922791012 cites W2052098936 @default.
• W2922791012 cites W2054535395 @default.
• W2922791012 cites W2076277579 @default.
• W2922791012 cites W2076323540 @default.
• W2922791012 cites W2089677127 @default.
• W2922791012 cites W2097357554 @default.
• W2922791012 cites W2106623141 @default.
• W2922791012 cites W2128203559 @default.
• W2922791012 cites W2129579709 @default.
• W2922791012 cites W2158031806 @default.
• W2922791012 cites W2167800954 @default.
• W2922791012 cites W2197078876 @default.
• W2922791012 cites W2214948900 @default.
• W2922791012 cites W2225304307 @default.
• W2922791012 cites W2229859804 @default.
• W2922791012 cites W2269415604 @default.
• W2922791012 cites W2288675656 @default.
• W2922791012 cites W2290405132 @default.
• W2922791012 cites W2346390990 @default.
• W2922791012 cites W2405927945 @default.
• W2922791012 cites W2431147098 @default.
• W2922791012 cites W2471446449 @default.
• W2922791012 cites W2509601827 @default.
• W2922791012 cites W2512235203 @default.
• W2922791012 cites W2553993334 @default.
• W2922791012 cites W2554445742 @default.
• W2922791012 cites W2558947971 @default.
• W2922791012 cites W2586346358 @default.
• W2922791012 cites W2587716329 @default.
• W2922791012 cites W2595110790 @default.
• W2922791012 cites W2607401518 @default.
• W2922791012 cites W2663388482 @default.
• W2922791012 cites W2732787110 @default.
• W2922791012 cites W2766059362 @default.
• W2922791012 cites W2766558591 @default.
• W2922791012 cites W2783872043 @default.
• W2922791012 cites W2785770559 @default.
• W2922791012 cites W2790010984 @default.
• W2922791012 cites W2802998522 @default.
• W2922791012 cites W2865698779 @default.
• W2922791012 doi "https://doi.org/10.1007/s12264-019-00367-8" @default.
• W2922791012 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6617494" @default.
• W2922791012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31177385" @default.
• W2922791012 hasPublicationYear "2019" @default.
• W2922791012 type Work @default.
• W2922791012 sameAs 2922791012 @default.
• W2922791012 citedByCount "26" @default.
• W2922791012 countsByYear W29227910122019 @default.
• W2922791012 countsByYear W29227910122020 @default.
• W2922791012 countsByYear W29227910122021 @default.
• W2922791012 countsByYear W29227910122022 @default.
• W2922791012 countsByYear W29227910122023 @default.
• W2922791012 crossrefType "journal-article" @default.
• W2922791012 hasAuthorship W2922791012A5004563088 @default.
• W2922791012 hasAuthorship W2922791012A5009613920 @default.
• W2922791012 hasAuthorship W2922791012A5028982370 @default.
• W2922791012 hasAuthorship W2922791012A5035282947 @default.
• W2922791012 hasAuthorship W2922791012A5043101749 @default.
• W2922791012 hasAuthorship W2922791012A5046775442 @default.
• W2922791012 hasAuthorship W2922791012A5059860203 @default.
• W2922791012 hasAuthorship W2922791012A5064955961 @default.
• W2922791012 hasAuthorship W2922791012A5067045315 @default.
• W2922791012 hasAuthorship W2922791012A5077265169 @default.

• next