FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922796611> ?p ?o ?g. }

• W2922796611 endingPage "81" @default.
• W2922796611 startingPage "76" @default.
• W2922796611 abstract "Small intestinal organoids have become an important tool to study crypt homeostasis, cell fate dynamics and tissue biomechanics. Yet, the mechanisms that drive the budding of crypts from the smooth organoid epithelium remain incompletely understood. Locally enhanced proliferation has been suggested to induce tissue buckling and crypt initiation. Here we report that changes in cell morphology play a crucial role in crypt formation. Crypt formation is preceded by local epithelial thickening, apicobasal elongation, and apical narrowing, resulting in a wedge-like cell-shape, followed by apical evagination and crypt outgrowth. Myosin II activity is found to coincide with apical constriction of cells, while inhibition of myosin suppresses apical constriction and bud formation. The data suggest that myosin-driven apical constriction is a key driving force of bud initiation in small intestinal organoids." @default.
• W2922796611 created "2019-04-01" @default.
• W2922796611 creator A5023970260 @default.
• W2922796611 creator A5035000089 @default.
• W2922796611 creator A5036763566 @default.
• W2922796611 creator A5045414992 @default.
• W2922796611 date "2019-06-01" @default.
• W2922796611 modified "2023-09-29" @default.
• W2922796611 title "Apical constriction is necessary for crypt formation in small intestinal organoids" @default.
• W2922796611 cites W1485031304 @default.
• W2922796611 cites W1566014451 @default.
• W2922796611 cites W1872124954 @default.
• W2922796611 cites W1974467110 @default.
• W2922796611 cites W1981924236 @default.
• W2922796611 cites W1992260947 @default.
• W2922796611 cites W2016624677 @default.
• W2922796611 cites W2026463969 @default.
• W2922796611 cites W2027302673 @default.
• W2922796611 cites W2044005732 @default.
• W2922796611 cites W2045237583 @default.
• W2922796611 cites W2053352622 @default.
• W2922796611 cites W2080098793 @default.
• W2922796611 cites W2081128785 @default.
• W2922796611 cites W2084964842 @default.
• W2922796611 cites W2093208620 @default.
• W2922796611 cites W2111214065 @default.
• W2922796611 cites W2113401723 @default.
• W2922796611 cites W2127367210 @default.
• W2922796611 cites W2133728642 @default.
• W2922796611 cites W2135384218 @default.
• W2922796611 cites W2151153178 @default.
• W2922796611 cites W2154994078 @default.
• W2922796611 cites W2156939613 @default.
• W2922796611 cites W2157010562 @default.
• W2922796611 cites W2158092398 @default.
• W2922796611 cites W2163949267 @default.
• W2922796611 cites W2168901267 @default.
• W2922796611 cites W2192354918 @default.
• W2922796611 cites W2260331015 @default.
• W2922796611 cites W2552754421 @default.
• W2922796611 cites W2585548548 @default.
• W2922796611 doi "https://doi.org/10.1016/j.ydbio.2019.03.009" @default.
• W2922796611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30914321" @default.
• W2922796611 hasPublicationYear "2019" @default.
• W2922796611 type Work @default.
• W2922796611 sameAs 2922796611 @default.
• W2922796611 citedByCount "21" @default.
• W2922796611 countsByYear W29227966112019 @default.
• W2922796611 countsByYear W29227966112020 @default.
• W2922796611 countsByYear W29227966112021 @default.
• W2922796611 countsByYear W29227966112022 @default.
• W2922796611 countsByYear W29227966112023 @default.
• W2922796611 crossrefType "journal-article" @default.
• W2922796611 hasAuthorship W2922796611A5023970260 @default.
• W2922796611 hasAuthorship W2922796611A5035000089 @default.
• W2922796611 hasAuthorship W2922796611A5036763566 @default.
• W2922796611 hasAuthorship W2922796611A5045414992 @default.
• W2922796611 hasBestOaLocation W29227966111 @default.
• W2922796611 hasConcept C104317684 @default.
• W2922796611 hasConcept C105702510 @default.
• W2922796611 hasConcept C134018914 @default.
• W2922796611 hasConcept C1491633281 @default.
• W2922796611 hasConcept C176080148 @default.
• W2922796611 hasConcept C198410946 @default.
• W2922796611 hasConcept C31695470 @default.
• W2922796611 hasConcept C39579648 @default.
• W2922796611 hasConcept C40692019 @default.
• W2922796611 hasConcept C529295009 @default.
• W2922796611 hasConcept C54355233 @default.
• W2922796611 hasConcept C55493867 @default.
• W2922796611 hasConcept C66090201 @default.
• W2922796611 hasConcept C6997183 @default.
• W2922796611 hasConcept C85813293 @default.
• W2922796611 hasConcept C86803240 @default.
• W2922796611 hasConcept C95444343 @default.
• W2922796611 hasConceptScore W2922796611C104317684 @default.
• W2922796611 hasConceptScore W2922796611C105702510 @default.
• W2922796611 hasConceptScore W2922796611C134018914 @default.
• W2922796611 hasConceptScore W2922796611C1491633281 @default.
• W2922796611 hasConceptScore W2922796611C176080148 @default.
• W2922796611 hasConceptScore W2922796611C198410946 @default.
• W2922796611 hasConceptScore W2922796611C31695470 @default.
• W2922796611 hasConceptScore W2922796611C39579648 @default.
• W2922796611 hasConceptScore W2922796611C40692019 @default.
• W2922796611 hasConceptScore W2922796611C529295009 @default.
• W2922796611 hasConceptScore W2922796611C54355233 @default.
• W2922796611 hasConceptScore W2922796611C55493867 @default.
• W2922796611 hasConceptScore W2922796611C66090201 @default.
• W2922796611 hasConceptScore W2922796611C6997183 @default.
• W2922796611 hasConceptScore W2922796611C85813293 @default.
• W2922796611 hasConceptScore W2922796611C86803240 @default.
• W2922796611 hasConceptScore W2922796611C95444343 @default.
• W2922796611 hasFunder F4320321800 @default.
• W2922796611 hasIssue "2" @default.
• W2922796611 hasLocation W29227966111 @default.
• W2922796611 hasLocation W29227966112 @default.
• W2922796611 hasOpenAccess W2922796611 @default.
• W2922796611 hasPrimaryLocation W29227966111 @default.

• next