Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922796664> ?p ?o ?g. }
- W2922796664 abstract "Abstract Objectives Because primary mesenchymal progenitor cells (adult‐MPCs) have various functions that depend on the tissue origin and donor, de novo MPCs from human pluripotent stem cells (hPSCs) would be required in regenerative medicine. However, the characteristics and function of MPCs derived from reprogrammed hPSCs have not been well studied. Thus, we show that functional MPCs can be successfully established from a single cell‐derived clonal expansion following MPC derivation from somatic cell nuclear transfer‐derived (SCNT)‐hPSCs, and these cells can serve as therapeutic contributors in an animal model of Asherman's syndrome (AS). Materials and methods We developed single cell‐derived clonal expansion following MPC derivation from SCNT‐hPSCs to offer a pure population and a higher biological activity. Additionally, we investigated the therapeutic effects of SCNT‐hPSC‐MPCs in model mice of Asherman's syndrome (AS), which is characterized by synechiae or fibrosis with endometrial injury. Results Their humoral effects in proliferating host cells encouraged angiogenesis and decreased pro‐inflammatory factors via a host‐dependent mechanism, resulting in reduction in AS. We also addressed that cellular activities such as the cell proliferation and population doubling of SCNT‐hPSC‐MPCs resemble those of human embryonic stem cell‐derived MPCs (hESC‐MPCs) and are much higher than those of adult‐MPCs. Conclusions Somatic cell nuclear transfer‐derived‐hPSCs‐MPCs could be an advanced therapeutic strategy for specific diseases in the field of regenerative medicine." @default.
- W2922796664 created "2019-04-01" @default.
- W2922796664 creator A5002290352 @default.
- W2922796664 creator A5003019453 @default.
- W2922796664 creator A5022857149 @default.
- W2922796664 creator A5028514548 @default.
- W2922796664 creator A5047086305 @default.
- W2922796664 creator A5049607620 @default.
- W2922796664 creator A5065055695 @default.
- W2922796664 creator A5080823003 @default.
- W2922796664 date "2019-03-21" @default.
- W2922796664 modified "2023-10-16" @default.
- W2922796664 title "Single cell‐derived clonally expanded mesenchymal progenitor cells from somatic cell nuclear transfer‐derived pluripotent stem cells ameliorate the endometrial function in the uterus of a murine model with Asherman’s syndrome" @default.
- W2922796664 cites W1543085590 @default.
- W2922796664 cites W1559742681 @default.
- W2922796664 cites W1660392447 @default.
- W2922796664 cites W1937647947 @default.
- W2922796664 cites W1968410373 @default.
- W2922796664 cites W1984965755 @default.
- W2922796664 cites W1987774343 @default.
- W2922796664 cites W2001147123 @default.
- W2922796664 cites W2006680614 @default.
- W2922796664 cites W2024706459 @default.
- W2922796664 cites W2027669322 @default.
- W2922796664 cites W2033719428 @default.
- W2922796664 cites W2049446122 @default.
- W2922796664 cites W2054095354 @default.
- W2922796664 cites W2059378220 @default.
- W2922796664 cites W2063341926 @default.
- W2922796664 cites W2064441872 @default.
- W2922796664 cites W2065571115 @default.
- W2922796664 cites W2071883174 @default.
- W2922796664 cites W2076491580 @default.
- W2922796664 cites W2086663462 @default.
- W2922796664 cites W2086943348 @default.
- W2922796664 cites W2092873757 @default.
- W2922796664 cites W2111727066 @default.
- W2922796664 cites W2114222046 @default.
- W2922796664 cites W2115281784 @default.
- W2922796664 cites W2121051882 @default.
- W2922796664 cites W2128553876 @default.
- W2922796664 cites W2129530584 @default.
- W2922796664 cites W2138977668 @default.
- W2922796664 cites W2154580143 @default.
- W2922796664 cites W2159999899 @default.
- W2922796664 cites W2193291380 @default.
- W2922796664 cites W2308714122 @default.
- W2922796664 cites W2554457530 @default.
- W2922796664 cites W2791471142 @default.
- W2922796664 doi "https://doi.org/10.1111/cpr.12597" @default.
- W2922796664 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6536448" @default.
- W2922796664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30896075" @default.
- W2922796664 hasPublicationYear "2019" @default.
- W2922796664 type Work @default.
- W2922796664 sameAs 2922796664 @default.
- W2922796664 citedByCount "16" @default.
- W2922796664 countsByYear W29227966642020 @default.
- W2922796664 countsByYear W29227966642021 @default.
- W2922796664 countsByYear W29227966642022 @default.
- W2922796664 countsByYear W29227966642023 @default.
- W2922796664 crossrefType "journal-article" @default.
- W2922796664 hasAuthorship W2922796664A5002290352 @default.
- W2922796664 hasAuthorship W2922796664A5003019453 @default.
- W2922796664 hasAuthorship W2922796664A5022857149 @default.
- W2922796664 hasAuthorship W2922796664A5028514548 @default.
- W2922796664 hasAuthorship W2922796664A5047086305 @default.
- W2922796664 hasAuthorship W2922796664A5049607620 @default.
- W2922796664 hasAuthorship W2922796664A5065055695 @default.
- W2922796664 hasAuthorship W2922796664A5080823003 @default.
- W2922796664 hasBestOaLocation W29227966641 @default.
- W2922796664 hasConcept C104317684 @default.
- W2922796664 hasConcept C107459253 @default.
- W2922796664 hasConcept C10854531 @default.
- W2922796664 hasConcept C134305767 @default.
- W2922796664 hasConcept C145103041 @default.
- W2922796664 hasConcept C196843134 @default.
- W2922796664 hasConcept C198826908 @default.
- W2922796664 hasConcept C201750760 @default.
- W2922796664 hasConcept C202438428 @default.
- W2922796664 hasConcept C203014093 @default.
- W2922796664 hasConcept C2778177303 @default.
- W2922796664 hasConcept C28328180 @default.
- W2922796664 hasConcept C2908647359 @default.
- W2922796664 hasConcept C502942594 @default.
- W2922796664 hasConcept C54355233 @default.
- W2922796664 hasConcept C71924100 @default.
- W2922796664 hasConcept C86803240 @default.
- W2922796664 hasConcept C87073359 @default.
- W2922796664 hasConcept C95444343 @default.
- W2922796664 hasConcept C99454951 @default.
- W2922796664 hasConceptScore W2922796664C104317684 @default.
- W2922796664 hasConceptScore W2922796664C107459253 @default.
- W2922796664 hasConceptScore W2922796664C10854531 @default.
- W2922796664 hasConceptScore W2922796664C134305767 @default.
- W2922796664 hasConceptScore W2922796664C145103041 @default.
- W2922796664 hasConceptScore W2922796664C196843134 @default.
- W2922796664 hasConceptScore W2922796664C198826908 @default.
- W2922796664 hasConceptScore W2922796664C201750760 @default.
- W2922796664 hasConceptScore W2922796664C202438428 @default.
- W2922796664 hasConceptScore W2922796664C203014093 @default.