FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922797727> ?p ?o ?g. }

• W2922797727 endingPage "704" @default.
• W2922797727 startingPage "695" @default.
• W2922797727 abstract "11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) catalyzes enzymatic conversion of cortisone into the stress hormone cortisol. This first-in-human brain imaging study characterizes the kinetic modeling and test–retest reproducibility of [ 18 F]AS2471907, a novel PET radiotracer for 11β-HSD1. Eight individuals underwent one 180-min ( n = 4) or two 240-min ( n = 4) [ 18 F]AS2471907 PET brain scans (12 total) acquired on the high-resolution research tomograph (HRRT) scanner with arterial blood sampling. Imaging data were modeled with 1-tissue (1T) and 2-tissue (2T) compartment models and with multilinear analysis (MA1) to estimate [ 18 F]AS2471907 availability ( V T ). [ 18 F]AS2471907 demonstrated high, heterogeneous uptake throughout the brain. Of the compartment models, 2T best described [ 18 F]AS2471907 data. Estimates of V T were highly correlated between 2T and MA1 ( t* = 30 min) with MA1 yielding V T values ranging from 3.2 ± 1.0 mL/cm 3 in the caudate to 15.7 ± 4.2 mL/cm 3 in the occipital cortex. The median absolute test–retest variability of 16 ± 5% and high intraclass correlation coefficient (ICC) values of 0.67–0.97 across regions indicate fair test–retest reliability but large intersubject variability. V T estimates using 180 min were within 10% of estimates using full acquisition time. In summary, [ 18 F]AS2471907 exhibits reasonable kinetic properties for imaging 11β-HSD1 in human brain." @default.
• W2922797727 created "2019-04-01" @default.
• W2922797727 creator A5004932337 @default.
• W2922797727 creator A5006508700 @default.
• W2922797727 creator A5012357230 @default.
• W2922797727 creator A5014166718 @default.
• W2922797727 creator A5042932147 @default.
• W2922797727 creator A5044085592 @default.
• W2922797727 creator A5046219145 @default.
• W2922797727 creator A5054839216 @default.
• W2922797727 creator A5062263815 @default.
• W2922797727 creator A5072017477 @default.
• W2922797727 creator A5084609706 @default.
• W2922797727 creator A5085371664 @default.
• W2922797727 creator A5089624017 @default.
• W2922797727 date "2019-03-21" @default.
• W2922797727 modified "2023-10-10" @default.
• W2922797727 title "First in-human PET study and kinetic evaluation of [¹⁸F]AS2471907 for imaging 11β-hydroxysteroid dehydrogenase type 1" @default.
• W2922797727 cites W161293699 @default.
• W2922797727 cites W1819145306 @default.
• W2922797727 cites W1977189703 @default.
• W2922797727 cites W1996323095 @default.
• W2922797727 cites W2001434260 @default.
• W2922797727 cites W2003158170 @default.
• W2922797727 cites W2015219993 @default.
• W2922797727 cites W2022724013 @default.
• W2922797727 cites W2024333989 @default.
• W2922797727 cites W2027953236 @default.
• W2922797727 cites W2032798922 @default.
• W2922797727 cites W2032932933 @default.
• W2922797727 cites W2055655674 @default.
• W2922797727 cites W2058046532 @default.
• W2922797727 cites W2063017390 @default.
• W2922797727 cites W2080788045 @default.
• W2922797727 cites W2109136796 @default.
• W2922797727 cites W2110948307 @default.
• W2922797727 cites W2112278807 @default.
• W2922797727 cites W2133069858 @default.
• W2922797727 cites W2145161166 @default.
• W2922797727 cites W2147337850 @default.
• W2922797727 cites W2152760742 @default.
• W2922797727 cites W2158809703 @default.
• W2922797727 cites W2162015134 @default.
• W2922797727 cites W2470594653 @default.
• W2922797727 cites W2567215542 @default.
• W2922797727 cites W2590990277 @default.
• W2922797727 cites W2601272645 @default.
• W2922797727 cites W2785820159 @default.
• W2922797727 cites W2913125849 @default.
• W2922797727 cites W2922037411 @default.
• W2922797727 cites W4233270027 @default.
• W2922797727 cites W4362207762 @default.
• W2922797727 doi "https://doi.org/10.1177/0271678x19838633" @default.
• W2922797727 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7168798" @default.
• W2922797727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30895878" @default.
• W2922797727 hasPublicationYear "2019" @default.
• W2922797727 type Work @default.
• W2922797727 sameAs 2922797727 @default.
• W2922797727 citedByCount "9" @default.
• W2922797727 countsByYear W29227977272021 @default.
• W2922797727 countsByYear W29227977272022 @default.
• W2922797727 countsByYear W29227977272023 @default.
• W2922797727 crossrefType "journal-article" @default.
• W2922797727 hasAuthorship W2922797727A5004932337 @default.
• W2922797727 hasAuthorship W2922797727A5006508700 @default.
• W2922797727 hasAuthorship W2922797727A5012357230 @default.
• W2922797727 hasAuthorship W2922797727A5014166718 @default.
• W2922797727 hasAuthorship W2922797727A5042932147 @default.
• W2922797727 hasAuthorship W2922797727A5044085592 @default.
• W2922797727 hasAuthorship W2922797727A5046219145 @default.
• W2922797727 hasAuthorship W2922797727A5054839216 @default.
• W2922797727 hasAuthorship W2922797727A5062263815 @default.
• W2922797727 hasAuthorship W2922797727A5072017477 @default.
• W2922797727 hasAuthorship W2922797727A5084609706 @default.
• W2922797727 hasAuthorship W2922797727A5085371664 @default.
• W2922797727 hasAuthorship W2922797727A5089624017 @default.
• W2922797727 hasBestOaLocation W29227977271 @default.
• W2922797727 hasConcept C104709138 @default.
• W2922797727 hasConcept C121332964 @default.
• W2922797727 hasConcept C154020017 @default.
• W2922797727 hasConcept C169760540 @default.
• W2922797727 hasConcept C185592680 @default.
• W2922797727 hasConcept C2777348757 @default.
• W2922797727 hasConcept C2777670902 @default.
• W2922797727 hasConcept C2989005 @default.
• W2922797727 hasConcept C43617362 @default.
• W2922797727 hasConcept C46141821 @default.
• W2922797727 hasConcept C71924100 @default.
• W2922797727 hasConcept C86803240 @default.
• W2922797727 hasConcept C89838059 @default.
• W2922797727 hasConcept C9893847 @default.
• W2922797727 hasConceptScore W2922797727C104709138 @default.
• W2922797727 hasConceptScore W2922797727C121332964 @default.
• W2922797727 hasConceptScore W2922797727C154020017 @default.
• W2922797727 hasConceptScore W2922797727C169760540 @default.
• W2922797727 hasConceptScore W2922797727C185592680 @default.
• W2922797727 hasConceptScore W2922797727C2777348757 @default.
• W2922797727 hasConceptScore W2922797727C2777670902 @default.

• next