Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922807795> ?p ?o ?g. }
- W2922807795 abstract "Unraveling the genetic susceptibility of complex diseases such as chronic kidney disease remains challenging. Here, we used inbred rat models of kidney damage associated with elevated blood pressure for the comprehensive analysis of a major albuminuria susceptibility locus detected in these models. We characterized its genomic architecture by congenic substitution mapping, targeted next-generation sequencing, and compartment-specific RNA sequencing analysis in isolated glomeruli. This led to prioritization of transmembrane protein Tmem63c as a novel potential target. Tmem63c is differentially expressed in glomeruli of allele-specific rat models during onset of albuminuria. Patients with focal segmental glomerulosclerosis exhibited specific TMEM63C loss in podocytes. Functional analysis in zebrafish revealed a role for tmem63c in mediating the glomerular filtration barrier function. Our data demonstrate that integrative analysis of the genomic architecture of a complex trait locus is a powerful tool for identification of new targets such as Tmem63c for further translational investigation." @default.
- W2922807795 created "2019-04-01" @default.
- W2922807795 creator A5002097111 @default.
- W2922807795 creator A5004743827 @default.
- W2922807795 creator A5018132916 @default.
- W2922807795 creator A5020604194 @default.
- W2922807795 creator A5021254433 @default.
- W2922807795 creator A5024324678 @default.
- W2922807795 creator A5025610581 @default.
- W2922807795 creator A5026432045 @default.
- W2922807795 creator A5027111313 @default.
- W2922807795 creator A5028714079 @default.
- W2922807795 creator A5029109689 @default.
- W2922807795 creator A5030608412 @default.
- W2922807795 creator A5033439567 @default.
- W2922807795 creator A5038455945 @default.
- W2922807795 creator A5058028736 @default.
- W2922807795 creator A5063361829 @default.
- W2922807795 creator A5085897629 @default.
- W2922807795 creator A5091113082 @default.
- W2922807795 creator A5091895035 @default.
- W2922807795 date "2019-03-22" @default.
- W2922807795 modified "2023-10-18" @default.
- W2922807795 title "Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage" @default.
- W2922807795 cites W1561757020 @default.
- W2922807795 cites W1779614964 @default.
- W2922807795 cites W1838763289 @default.
- W2922807795 cites W1875965364 @default.
- W2922807795 cites W1919257374 @default.
- W2922807795 cites W1964917997 @default.
- W2922807795 cites W1969194165 @default.
- W2922807795 cites W1971256560 @default.
- W2922807795 cites W1973477181 @default.
- W2922807795 cites W1991751528 @default.
- W2922807795 cites W1993074652 @default.
- W2922807795 cites W2008317079 @default.
- W2922807795 cites W2012034410 @default.
- W2922807795 cites W2020212337 @default.
- W2922807795 cites W2023358602 @default.
- W2922807795 cites W2027854295 @default.
- W2922807795 cites W2041467022 @default.
- W2922807795 cites W2054538825 @default.
- W2922807795 cites W2059061809 @default.
- W2922807795 cites W2070870822 @default.
- W2922807795 cites W2072500831 @default.
- W2922807795 cites W2089335658 @default.
- W2922807795 cites W2089355200 @default.
- W2922807795 cites W2090235291 @default.
- W2922807795 cites W2097065948 @default.
- W2922807795 cites W2097656361 @default.
- W2922807795 cites W2103441770 @default.
- W2922807795 cites W2105769855 @default.
- W2922807795 cites W2106578986 @default.
- W2922807795 cites W2106806242 @default.
- W2922807795 cites W2107196928 @default.
- W2922807795 cites W2108525019 @default.
- W2922807795 cites W2122941722 @default.
- W2922807795 cites W2125107211 @default.
- W2922807795 cites W2129416468 @default.
- W2922807795 cites W2133176024 @default.
- W2922807795 cites W2134340460 @default.
- W2922807795 cites W2135917011 @default.
- W2922807795 cites W2137509038 @default.
- W2922807795 cites W2140095783 @default.
- W2922807795 cites W2140784970 @default.
- W2922807795 cites W2141458291 @default.
- W2922807795 cites W2148663005 @default.
- W2922807795 cites W2149964263 @default.
- W2922807795 cites W2149992227 @default.
- W2922807795 cites W2150989567 @default.
- W2922807795 cites W2151367032 @default.
- W2922807795 cites W2163543028 @default.
- W2922807795 cites W2164076161 @default.
- W2922807795 cites W2164695230 @default.
- W2922807795 cites W2167279371 @default.
- W2922807795 cites W2167557672 @default.
- W2922807795 cites W2168450345 @default.
- W2922807795 cites W2168798091 @default.
- W2922807795 cites W2170551349 @default.
- W2922807795 cites W2179438025 @default.
- W2922807795 cites W2180226417 @default.
- W2922807795 cites W2183868793 @default.
- W2922807795 cites W2222574236 @default.
- W2922807795 cites W2241269383 @default.
- W2922807795 cites W2285849045 @default.
- W2922807795 cites W2337520510 @default.
- W2922807795 cites W2340761255 @default.
- W2922807795 cites W2343277111 @default.
- W2922807795 cites W2404974138 @default.
- W2922807795 cites W2413880999 @default.
- W2922807795 cites W2420607835 @default.
- W2922807795 cites W2464717012 @default.
- W2922807795 cites W2470282799 @default.
- W2922807795 cites W2519445944 @default.
- W2922807795 cites W2531928944 @default.
- W2922807795 cites W2556167715 @default.
- W2922807795 cites W2581246226 @default.
- W2922807795 cites W2581452190 @default.
- W2922807795 cites W2582089647 @default.
- W2922807795 cites W2724183530 @default.