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- W2922809637 abstract "Background: Biomarkers in cognitively vulnerable populations like those with coronary artery disease (CAD) may inform earlier intervention in vascular neurodegeneration. Circulating ceramide C18:0 (CerC18:0) is associated with cognitive changes in early neurodegeneration and CAD progression. Objective: To investigate whether plasma CerC18:0 accumulation is associated with longitudinal declines in verbal memory in CAD.Methods: In addition to CerC18:0, we assessed its relative abundance to its precursors as ratios: to monohexosylceramide C18:0 (CerC18:0/MHxCer18:0), to sphingomyelin C18:0 (CerC18:0/SM18:0), and to sphingosine-1-phosphate (CerC18:0/S1P). In 60 CAD participants, we evaluated associations between baseline CerC18:0 and its ratios to changes in verbal memory, adjusted for potential confounders. Results: Increased baseline CerC18:0 (b[SE]=-0.91[0.30], p=0.003), CerC18:0/MHxCerC18:0 [(b[SE]=-0.90[0.40], p=0.03)], CerC18:0/SM18:0 (b[SE]=-1.11[0.36], p=0.004) correlated with steeper declines in verbal memory. Conclusions: Aberrant CerC18:0 metabolism may be an early neurobiological change in vascular neurodegeneration. Future studies should measure enzymatic activity responsible for conversion of precursors into CerC18:0.%%%%M.Sc." @default.
- W2922809637 created "2019-04-01" @default.
- W2922809637 creator A5033493014 @default.
- W2922809637 date "2018-06-01" @default.
- W2922809637 modified "2023-09-27" @default.
- W2922809637 title "Biomarkers of Ceramide Accumulation and Decline in Verbal Memory in Coronary Artery Disease" @default.
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