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• W2922819162 abstract "Abstract Purpose To evaluate the effect of conbercept on the expression of long noncoding RNA s (lnc RNA s) and mRNA s in the fibrovascular membranes of proliferative diabetic retinopathy ( PDR ) patients. Methods Twenty patients, diagnosed with PDR , who underwent pars plana vitrectomy ( PPV ), were recruited for this study. Ten patients were treated for PPV alone (Control Group), and the others received conbercept injections before PPV (Treated Group). The fibrovascular membranes were harvested during surgery. Expression of lnc RNA s and mRNA s in the membranes was tested using lnc RNA Arrays. Bioinformatics analyses were performed to identify the related biological modules and pathways of the differentially expressed genes. A lnc RNA / mRNA coexpression network was built to identify the correlations between lnc RNA s and mRNA s. Real‐time PCR was conducted to verify the microarray results. Results We identified 427 differentially expressed lnc RNA s, of which 263 were upregulated and 164 were downregulated. Gene ontology ( GO ) analysis indicated that these lnc RNA s–coexpressed mRNA s targeted various metabolic processes, especially the gluconeogenesis. Kyoto Encyclopaedia of Genes and Genomes (KEGG) results indicated that 16 pathways had significant differences in gene expression, including gluconeogenesis, HIF ‐1 signalling pathway, NOD ‐like receptor pathway, etc. The lnc RNA / mRNA coexpression network revealed that many differentially expressed lnc RNA s were enriched in the HIF ‐1, TNF ‐ α and NOD ‐like receptor pathways. Linc RNA s were the largest category and further bioinformatics analysis implied that these linc RNA s–coexpressed mRNA s were mainly involved in PDR ‐related biological processes and pathological pathways. Conclusion Conbercept treatment can change the expression profiles of lnc RNA s and mRNA s in the fibrovascular membranes of PDR patients. A complete understanding of the relationship between lnc RNA s and anti‐ VEGF drugs may contribute to new therapeutic regimen for PDR ." @default.
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• W2922819162 date "2019-03-22" @default.
• W2922819162 modified "2023-10-04" @default.
• W2922819162 title "Effect of intravitreal conbercept treatment on the expression of Long Noncoding <scp>RNA</scp> s and <scp>mRNA</scp> s in Proliferative Diabetic Retinopathy Patients" @default.
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• W2922819162 doi "https://doi.org/10.1111/aos.14083" @default.
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