FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922896100> ?p ?o ?g. }

• W2922896100 abstract "Semaphorin 3A (sema3A) belongs to the sub-family of the immune semaphorins that function as regulators of immune-mediated inflammation. Sema3A is a membrane associated molecule on T regulatory cells and on B regulatory cells. Being transiently ligated to the cell surface of these cells it is suggested to be a useful marker for evaluating their functional status. In earlier studies, we found that reduced sema3A concentration in the serum of asthma patients as well as reduced expression by Treg cells correlates with asthma disease severity. Stimulation of Treg cells with recombinant sema3A induced a significant increase in FoxP3 and IL-10 expression. To find out if sema3A can be of benefit to asthma patients, we evaluated the effect of sema3A injection in a mouse model of asthma. BALBc-mice were sensitized using ovalbumin (OVA) + adjuvant for 15 days followed by OVA aerosol inhalation over five consecutive days. Four hours following air ways sensitization on each of the above days- 15 of these mice were injected intraperitoneally with 50 μg per mouse of recombinant human sema3A-FR and the remaining 15 mice were injected with a similarly purified vehicle. Five days later the mice were sacrificed, broncheo-alveolar lavage (BAL) was collected and formalin-fixed lung biopsies taken and analyzed. In sema3A treated mice, only 20% of the bronchioles and arterioles were infiltrated by inflammatory cells as compared to 90% in the control group (P=0.0079). In addition, eosinophil infiltration was also significantly increased in the control group as compared with the sema3A treated mice. In sema3A treated mice we noticed only a small number of mononuclear and neutrophil cells in the BAL while in the control mice, the BAL was enriched with mononuclear and neutrophil cells. Finally, in the control mice, angiogenesis was significantly increased in comparison with sema3A treated mice as evidenced by the reduced concentration of microvessels in the lungs of sema3A treated mice. To conclude, we find that in this asthma model, sema3A functions as a potent suppressor of asthma related inflammation that has the potential to be further developed as a new therapeutic for the treatment of asthma." @default.
• W2922896100 created "2019-04-01" @default.
• W2922896100 creator A5007064132 @default.
• W2922896100 creator A5030319856 @default.
• W2922896100 creator A5038599659 @default.
• W2922896100 creator A5044819086 @default.
• W2922896100 creator A5047697764 @default.
• W2922896100 creator A5074383267 @default.
• W2922896100 creator A5074589265 @default.
• W2922896100 creator A5084932868 @default.
• W2922896100 creator A5087975525 @default.
• W2922896100 date "2019-03-22" @default.
• W2922896100 modified "2023-10-03" @default.
• W2922896100 title "Semaphorin 3A Is Effective in Reducing Both Inflammation and Angiogenesis in a Mouse Model of Bronchial Asthma" @default.
• W2922896100 cites W1683374937 @default.
• W2922896100 cites W1977380429 @default.
• W2922896100 cites W1984145469 @default.
• W2922896100 cites W1985403743 @default.
• W2922896100 cites W1986877868 @default.
• W2922896100 cites W1992507453 @default.
• W2922896100 cites W2016875074 @default.
• W2922896100 cites W2017829703 @default.
• W2922896100 cites W2019406979 @default.
• W2922896100 cites W2037128222 @default.
• W2922896100 cites W2053553859 @default.
• W2922896100 cites W2055612012 @default.
• W2922896100 cites W2081454211 @default.
• W2922896100 cites W2087310183 @default.
• W2922896100 cites W2092068315 @default.
• W2922896100 cites W2102025068 @default.
• W2922896100 cites W2104085750 @default.
• W2922896100 cites W2149675391 @default.
• W2922896100 cites W2151287143 @default.
• W2922896100 cites W2156222533 @default.
• W2922896100 cites W2216267862 @default.
• W2922896100 cites W2518458556 @default.
• W2922896100 cites W2533218268 @default.
• W2922896100 cites W2553592838 @default.
• W2922896100 cites W2613520879 @default.
• W2922896100 cites W2620108622 @default.
• W2922896100 cites W2628117813 @default.
• W2922896100 cites W2764260555 @default.
• W2922896100 cites W2766788308 @default.
• W2922896100 cites W2772289015 @default.
• W2922896100 cites W2775629330 @default.
• W2922896100 cites W2796141357 @default.
• W2922896100 cites W2807847759 @default.
• W2922896100 cites W2889063029 @default.
• W2922896100 cites W2897426253 @default.
• W2922896100 cites W2906933620 @default.
• W2922896100 doi "https://doi.org/10.3389/fimmu.2019.00550" @default.
• W2922896100 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6439418" @default.
• W2922896100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30967873" @default.
• W2922896100 hasPublicationYear "2019" @default.
• W2922896100 type Work @default.
• W2922896100 sameAs 2922896100 @default.
• W2922896100 citedByCount "20" @default.
• W2922896100 countsByYear W29228961002019 @default.
• W2922896100 countsByYear W29228961002020 @default.
• W2922896100 countsByYear W29228961002021 @default.
• W2922896100 countsByYear W29228961002022 @default.
• W2922896100 countsByYear W29228961002023 @default.
• W2922896100 crossrefType "journal-article" @default.
• W2922896100 hasAuthorship W2922896100A5007064132 @default.
• W2922896100 hasAuthorship W2922896100A5030319856 @default.
• W2922896100 hasAuthorship W2922896100A5038599659 @default.
• W2922896100 hasAuthorship W2922896100A5044819086 @default.
• W2922896100 hasAuthorship W2922896100A5047697764 @default.
• W2922896100 hasAuthorship W2922896100A5074383267 @default.
• W2922896100 hasAuthorship W2922896100A5074589265 @default.
• W2922896100 hasAuthorship W2922896100A5084932868 @default.
• W2922896100 hasAuthorship W2922896100A5087975525 @default.
• W2922896100 hasBestOaLocation W29228961001 @default.
• W2922896100 hasConcept C126322002 @default.
• W2922896100 hasConcept C132538176 @default.
• W2922896100 hasConcept C170493617 @default.
• W2922896100 hasConcept C203014093 @default.
• W2922896100 hasConcept C2776042228 @default.
• W2922896100 hasConcept C2776217527 @default.
• W2922896100 hasConcept C2776805952 @default.
• W2922896100 hasConcept C2776914184 @default.
• W2922896100 hasConcept C2776946954 @default.
• W2922896100 hasConcept C2777037409 @default.
• W2922896100 hasConcept C2779675166 @default.
• W2922896100 hasConcept C2779727006 @default.
• W2922896100 hasConcept C71924100 @default.
• W2922896100 hasConcept C8891405 @default.
• W2922896100 hasConceptScore W2922896100C126322002 @default.
• W2922896100 hasConceptScore W2922896100C132538176 @default.
• W2922896100 hasConceptScore W2922896100C170493617 @default.
• W2922896100 hasConceptScore W2922896100C203014093 @default.
• W2922896100 hasConceptScore W2922896100C2776042228 @default.
• W2922896100 hasConceptScore W2922896100C2776217527 @default.
• W2922896100 hasConceptScore W2922896100C2776805952 @default.
• W2922896100 hasConceptScore W2922896100C2776914184 @default.
• W2922896100 hasConceptScore W2922896100C2776946954 @default.
• W2922896100 hasConceptScore W2922896100C2777037409 @default.
• W2922896100 hasConceptScore W2922896100C2779675166 @default.
• W2922896100 hasConceptScore W2922896100C2779727006 @default.
• W2922896100 hasConceptScore W2922896100C71924100 @default.

• next