FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922915037> ?p ?o ?g. }

• W2922915037 endingPage "325" @default.
• W2922915037 startingPage "311" @default.
• W2922915037 abstract "Non-small cell lung cancer (NSCLC) is the most common type of lung cancer with a poor prognosis. We previously found that protein disulfide isomerase family 6 (PDIA6) is upregulated in lung squamous cell carcinoma (LSCC). This study aimed to elucidate the clinical relevance, biological functions, and molecular mechanisms of PDIA6 in NSCLC.The expression of PDIA6 in NSCLC was assessed using the TCGA database, western blotting, and immunohistochemistry. Correlations of PDIA6 expression with clinicopathological and survival features were evaluated. The functions of PDIA6 in regulating NSCLC cell growth, apoptosis, and autophagy were investigated using gain-and loss-of-function strategies in vitro or in vivo. The underlying molecular mechanisms of PDIA6 function were examined by human phospho-kinase array and co-immunoprecipitation.PDIA6 expression was upregulated in NSCLC compared with adjacent normal tissues, and the higher PDIA6 expression was correlated with poor prognosis. PDIA6 knockdown decreased NSCLC cell proliferation and increased cisplatin-induced intrinsic apoptosis, while PDIA6 overexpression had the opposite effects. In addition, PDIA6 regulated cisplatin-induced autophagy, and this contributed to PDIA6-mediated apoptosis in NSCLC cells. Mechanistically, PDIA6 reduced the phosphorylation levels of JNK and c-Jun. Moreover, PDIA6 interacted with MAP4K1 and inhibited its phosphorylation, ultimately inhibiting the JNK/c-Jun signaling pathway.PDIA6 is overexpressed in NSCLC and inhibits cisplatin-induced NSCLC cell apoptosis and autophagy via the MAP4K1/JNK/c-Jun signaling pathway, suggesting that PDIA6 may serve as a biomarker and therapeutic target for NSCLC patients. FUND: National Natural Science Foundation of China and Institutions of higher learning of innovation team from Liaoning province." @default.
• W2922915037 created "2019-04-01" @default.
• W2922915037 creator A5006294670 @default.
• W2922915037 creator A5008736880 @default.
• W2922915037 creator A5020095522 @default.
• W2922915037 creator A5021823717 @default.
• W2922915037 creator A5026259727 @default.
• W2922915037 creator A5027937292 @default.
• W2922915037 creator A5029397237 @default.
• W2922915037 creator A5032499168 @default.
• W2922915037 creator A5045525984 @default.
• W2922915037 creator A5046350940 @default.
• W2922915037 creator A5051862250 @default.
• W2922915037 creator A5057633505 @default.
• W2922915037 creator A5068691811 @default.
• W2922915037 creator A5073315881 @default.
• W2922915037 creator A5075659421 @default.
• W2922915037 creator A5076873621 @default.
• W2922915037 creator A5077679037 @default.
• W2922915037 date "2019-04-01" @default.
• W2922915037 modified "2023-10-18" @default.
• W2922915037 title "PDIA6 modulates apoptosis and autophagy of non-small cell lung cancer cells via the MAP4K1/JNK signaling pathway" @default.
• W2922915037 cites W1528485412 @default.
• W2922915037 cites W161910285 @default.
• W2922915037 cites W1789901929 @default.
• W2922915037 cites W1846719279 @default.
• W2922915037 cites W1968867081 @default.
• W2922915037 cites W1969393277 @default.
• W2922915037 cites W1971967721 @default.
• W2922915037 cites W1978505234 @default.
• W2922915037 cites W1979842763 @default.
• W2922915037 cites W1983917564 @default.
• W2922915037 cites W1984903682 @default.
• W2922915037 cites W1987604182 @default.
• W2922915037 cites W1988740497 @default.
• W2922915037 cites W1990228733 @default.
• W2922915037 cites W1990239056 @default.
• W2922915037 cites W2002439304 @default.
• W2922915037 cites W2002642746 @default.
• W2922915037 cites W2004457956 @default.
• W2922915037 cites W2007154778 @default.
• W2922915037 cites W2009101631 @default.
• W2922915037 cites W2009183786 @default.
• W2922915037 cites W2014235417 @default.
• W2922915037 cites W2019093886 @default.
• W2922915037 cites W2022724942 @default.
• W2922915037 cites W2034213169 @default.
• W2922915037 cites W2034586348 @default.
• W2922915037 cites W2038272987 @default.
• W2922915037 cites W2041943889 @default.
• W2922915037 cites W2045457634 @default.
• W2922915037 cites W2045601601 @default.
• W2922915037 cites W2052627330 @default.
• W2922915037 cites W2056274991 @default.
• W2922915037 cites W2061932411 @default.
• W2922915037 cites W2062943475 @default.
• W2922915037 cites W2063635860 @default.
• W2922915037 cites W2063761428 @default.
• W2922915037 cites W2066964642 @default.
• W2922915037 cites W2069529251 @default.
• W2922915037 cites W2070142059 @default.
• W2922915037 cites W2078911476 @default.
• W2922915037 cites W2079282879 @default.
• W2922915037 cites W2079351077 @default.
• W2922915037 cites W2079492794 @default.
• W2922915037 cites W2080389159 @default.
• W2922915037 cites W2085169607 @default.
• W2922915037 cites W2104504726 @default.
• W2922915037 cites W2110806257 @default.
• W2922915037 cites W2112737323 @default.
• W2922915037 cites W2119683782 @default.
• W2922915037 cites W2121429373 @default.
• W2922915037 cites W2135296179 @default.
• W2922915037 cites W2164998112 @default.
• W2922915037 cites W2275094803 @default.
• W2922915037 cites W2417836321 @default.
• W2922915037 cites W2537642000 @default.
• W2922915037 cites W2748992543 @default.
• W2922915037 cites W2760931277 @default.
• W2922915037 cites W2781525129 @default.
• W2922915037 cites W2788640168 @default.
• W2922915037 cites W2895492364 @default.
• W2922915037 cites W2902488470 @default.
• W2922915037 cites W1964184380 @default.
• W2922915037 doi "https://doi.org/10.1016/j.ebiom.2019.03.045" @default.
• W2922915037 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6491656" @default.
• W2922915037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30922965" @default.
• W2922915037 hasPublicationYear "2019" @default.
• W2922915037 type Work @default.
• W2922915037 sameAs 2922915037 @default.
• W2922915037 citedByCount "53" @default.
• W2922915037 countsByYear W29229150372019 @default.
• W2922915037 countsByYear W29229150372020 @default.
• W2922915037 countsByYear W29229150372021 @default.
• W2922915037 countsByYear W29229150372022 @default.
• W2922915037 countsByYear W29229150372023 @default.
• W2922915037 crossrefType "journal-article" @default.
• W2922915037 hasAuthorship W2922915037A5006294670 @default.

• next