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- W2922933922 startingPage "414" @default.
- W2922933922 abstract "The blood–brain barrier (BBB) plays an important role in brain homeostasis. Hypoxia/ischemia constitutes an important stress factor involved in several neurological disorders by inducing the disruption of the BBB, ultimately leading to cerebral edema formation. Yet, our current understanding of the cellular and molecular mechanisms underlying the BBB disruption following cerebral hypoxia/ischemia remains limited. Stem cell-based models of the human BBB present some potentials to address such issues. Yet, such models have not been validated in regard of its ability to respond to hypoxia/ischemia as existing models. In this study, we investigated the cellular response of two iPSC-derived brain microvascular endothelial cell (BMEC) monolayers to respond to oxygen-glucose deprivation (OGD) stress, using two induced pluripotent stem cells (iPSC) lines. iPSC-derived BMECs responded to prolonged (24 h) and acute (6 h) OGD by showing a decrease in the barrier function and a decrease in tight junction complexes. Such iPSC-derived BMECs responded to OGD stress via a partial activation of the HIF-1 pathway, whereas treatment with anti-angiogenic pharmacological inhibitors (sorafenib, sunitinib) during reoxygenation worsened the barrier function. Taken together, our results suggest such models can respond to hypoxia/ischemia similarly to existing in vitro models and support the possible use of this model as a screening platform for identifying novel drug candidates capable to restore the barrier function following hypoxic/ischemic injury." @default.
- W2922933922 created "2019-04-01" @default.
- W2922933922 creator A5002885033 @default.
- W2922933922 creator A5047910951 @default.
- W2922933922 creator A5057900193 @default.
- W2922933922 date "2019-03-26" @default.
- W2922933922 modified "2023-09-27" @default.
- W2922933922 title "Oxygen-Glucose Deprivation/Reoxygenation-Induced Barrier Disruption at the Human Blood–Brain Barrier is Partially Mediated Through the HIF-1 Pathway" @default.
- W2922933922 cites W1492624003 @default.
- W2922933922 cites W1561584024 @default.
- W2922933922 cites W1685239234 @default.
- W2922933922 cites W1837885345 @default.
- W2922933922 cites W1848460937 @default.
- W2922933922 cites W1884483916 @default.
- W2922933922 cites W1897292152 @default.
- W2922933922 cites W1902114397 @default.
- W2922933922 cites W1924217464 @default.
- W2922933922 cites W1964337161 @default.
- W2922933922 cites W1964508300 @default.
- W2922933922 cites W1966389744 @default.
- W2922933922 cites W1969794746 @default.
- W2922933922 cites W1971287132 @default.
- W2922933922 cites W1972975985 @default.
- W2922933922 cites W1975412808 @default.
- W2922933922 cites W1975535580 @default.
- W2922933922 cites W1975884974 @default.
- W2922933922 cites W1976916618 @default.
- W2922933922 cites W1985240641 @default.
- W2922933922 cites W1985455477 @default.
- W2922933922 cites W1988492326 @default.
- W2922933922 cites W1991425223 @default.
- W2922933922 cites W1992866322 @default.
- W2922933922 cites W1995364787 @default.
- W2922933922 cites W1998237791 @default.
- W2922933922 cites W2008336268 @default.
- W2922933922 cites W2010136682 @default.
- W2922933922 cites W2011076742 @default.
- W2922933922 cites W2011804660 @default.
- W2922933922 cites W2014386715 @default.
- W2922933922 cites W2021432629 @default.
- W2922933922 cites W2021850662 @default.
- W2922933922 cites W2024025249 @default.
- W2922933922 cites W2024486369 @default.
- W2922933922 cites W2026601790 @default.
- W2922933922 cites W2027261562 @default.
- W2922933922 cites W2028858227 @default.
- W2922933922 cites W2028879698 @default.
- W2922933922 cites W2029939672 @default.
- W2922933922 cites W2030982986 @default.
- W2922933922 cites W2042883482 @default.
- W2922933922 cites W2043752409 @default.
- W2922933922 cites W2046770236 @default.
- W2922933922 cites W2048468641 @default.
- W2922933922 cites W2051617804 @default.
- W2922933922 cites W2056155493 @default.
- W2922933922 cites W2060549911 @default.
- W2922933922 cites W2066343379 @default.
- W2922933922 cites W2068337543 @default.
- W2922933922 cites W2069589352 @default.
- W2922933922 cites W2070940233 @default.
- W2922933922 cites W2072182561 @default.
- W2922933922 cites W2080938528 @default.
- W2922933922 cites W2084498863 @default.
- W2922933922 cites W2086074238 @default.
- W2922933922 cites W2088479307 @default.
- W2922933922 cites W2088504232 @default.
- W2922933922 cites W2101957440 @default.
- W2922933922 cites W2103422183 @default.
- W2922933922 cites W2107798346 @default.
- W2922933922 cites W2109503237 @default.
- W2922933922 cites W2111149177 @default.
- W2922933922 cites W2116759862 @default.
- W2922933922 cites W2116881591 @default.
- W2922933922 cites W2119850253 @default.
- W2922933922 cites W2121212243 @default.
- W2922933922 cites W2121766795 @default.
- W2922933922 cites W2124116160 @default.
- W2922933922 cites W2133278451 @default.
- W2922933922 cites W2137038184 @default.
- W2922933922 cites W2139972598 @default.
- W2922933922 cites W2141957876 @default.
- W2922933922 cites W2142046859 @default.
- W2922933922 cites W2153508530 @default.
- W2922933922 cites W2159801053 @default.
- W2922933922 cites W2162189519 @default.
- W2922933922 cites W2164047895 @default.
- W2922933922 cites W2171768182 @default.
- W2922933922 cites W2192116454 @default.
- W2922933922 cites W2201221710 @default.
- W2922933922 cites W2223292741 @default.
- W2922933922 cites W2253301869 @default.
- W2922933922 cites W2260748729 @default.
- W2922933922 cites W2277219084 @default.
- W2922933922 cites W2294294416 @default.
- W2922933922 cites W2299568419 @default.
- W2922933922 cites W2302006867 @default.
- W2922933922 cites W2308060200 @default.
- W2922933922 cites W2315903706 @default.