FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922981517> ?p ?o ?g. }

• W2922981517 abstract "Objective: To describe clinical, radiologic manifestations and treatment outcomes in 107 patients with neurosarcoidosis. Background: Neurosarcoidosis (NS) is reported in less than 5[percnt] of patients with systemic sarcoidosis while isolated NS without systemic involvement represents 17[percnt] of NS. A definitive diagnosis requires histologic confirmation, which rarely is obtained in NS. Our current knowledge for diagnosis and treatment relies on case reports. Methods: The study setting was a large, integrated health care system serving southeastern Michigan. 107 patients seen from 1995-2015 were found to meet the criteria for definitive, probable or possible NS (Zajicek, 1999). Neurological symptoms, sociodemographic, laboratory, radiographic and treatment data were collected. Descriptive statistics and chi-square tests were conducted using SAS version 9.4. Results: Of 107 patients, 58[percnt] were male and 74[percnt] African American. Average age of presentation was 49.1 year. Brain was the most common site involved (50[percnt]), followed by cranial nerves (39[percnt]), spine (29[percnt]). Majority (81[percnt]) had multisystem sarcoidosis with lung most commonly involved (56[percnt]). For those with complete workup, blood ACE was elevated in half of patients and only a third had elevated CSF ACE (29[percnt]). Significantly higher rates of elevated blood ACE were seen in patients with multisystem involvement (p=0.005). Abnormal laboratory tests seen frequently were elevated CSF WBC (65[percnt]), elevated CSF protein (53[percnt]) and elevated serum C-reactive protein (75[percnt]). Most common clinical presentations were headache (20[percnt]), optic neuritis (13[percnt]), myelitis (13[percnt]) and Bell’s palsy (8[percnt]). Prednisone was used as initial treatment (93[percnt]) while methotrexate was the most common used long term immunosuppressant (35[percnt]). Conclusion: We present the largest described case series of NS. Clinical presentation was diverse with multi-system involvement in most cases. We found that certain laboratory tests may be useful tools for diagnosis. Further epidemiological analysis is needed to develop prediction models and better screening programs for early detection. Disclosure: Dr. Affan has nothing to disclose. Dr. Schultz has nothing to disclose. Dr. Cerghet has nothing to disclose. Dr. Elias has nothing to disclose." @default.
• W2922981517 created "2019-04-01" @default.
• W2922981517 creator A5021590878 @default.
• W2922981517 creator A5032387130 @default.
• W2922981517 creator A5062959009 @default.
• W2922981517 creator A5066820659 @default.
• W2922981517 date "2016-04-05" @default.
• W2922981517 modified "2023-09-26" @default.
• W2922981517 title "Clinical and Radiological Presentation of Neurosarcoidosis: Single Center Cohort Study of 107 Cases (P6.114)" @default.
• W2922981517 hasPublicationYear "2016" @default.
• W2922981517 type Work @default.
• W2922981517 sameAs 2922981517 @default.
• W2922981517 citedByCount "0" @default.
• W2922981517 crossrefType "journal-article" @default.
• W2922981517 hasAuthorship W2922981517A5021590878 @default.
• W2922981517 hasAuthorship W2922981517A5032387130 @default.
• W2922981517 hasAuthorship W2922981517A5062959009 @default.
• W2922981517 hasAuthorship W2922981517A5066820659 @default.
• W2922981517 hasConcept C126322002 @default.
• W2922981517 hasConcept C141071460 @default.
• W2922981517 hasConcept C187212893 @default.
• W2922981517 hasConcept C190892606 @default.
• W2922981517 hasConcept C2777601897 @default.
• W2922981517 hasConcept C2778335692 @default.
• W2922981517 hasConcept C2781301800 @default.
• W2922981517 hasConcept C71924100 @default.
• W2922981517 hasConcept C72563966 @default.
• W2922981517 hasConceptScore W2922981517C126322002 @default.
• W2922981517 hasConceptScore W2922981517C141071460 @default.
• W2922981517 hasConceptScore W2922981517C187212893 @default.
• W2922981517 hasConceptScore W2922981517C190892606 @default.
• W2922981517 hasConceptScore W2922981517C2777601897 @default.
• W2922981517 hasConceptScore W2922981517C2778335692 @default.
• W2922981517 hasConceptScore W2922981517C2781301800 @default.
• W2922981517 hasConceptScore W2922981517C71924100 @default.
• W2922981517 hasConceptScore W2922981517C72563966 @default.
• W2922981517 hasLocation W29229815171 @default.
• W2922981517 hasOpenAccess W2922981517 @default.
• W2922981517 hasPrimaryLocation W29229815171 @default.
• W2922981517 hasRelatedWork W1415334801 @default.
• W2922981517 hasRelatedWork W1514145731 @default.
• W2922981517 hasRelatedWork W1872831990 @default.
• W2922981517 hasRelatedWork W1930398478 @default.
• W2922981517 hasRelatedWork W2104761723 @default.
• W2922981517 hasRelatedWork W2321661780 @default.
• W2922981517 hasRelatedWork W2336774134 @default.
• W2922981517 hasRelatedWork W2474546753 @default.
• W2922981517 hasRelatedWork W2572683118 @default.
• W2922981517 hasRelatedWork W2755354852 @default.
• W2922981517 hasRelatedWork W2771779128 @default.
• W2922981517 hasRelatedWork W2793757941 @default.
• W2922981517 hasRelatedWork W2798254827 @default.
• W2922981517 hasRelatedWork W2896407659 @default.
• W2922981517 hasRelatedWork W2929012195 @default.
• W2922981517 hasRelatedWork W2947400229 @default.
• W2922981517 hasRelatedWork W2950341730 @default.
• W2922981517 hasRelatedWork W3174270532 @default.
• W2922981517 hasRelatedWork W570630557 @default.
• W2922981517 hasRelatedWork W908769252 @default.
• W2922981517 hasVolume "86" @default.
• W2922981517 isParatext "false" @default.
• W2922981517 isRetracted "false" @default.
• W2922981517 magId "2922981517" @default.
• W2922981517 workType "article" @default.