Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922987091> ?p ?o ?g. }
- W2922987091 abstract "Prostate cancer is the most frequently diagnosed cancer among men, with an incidence rate of 1 in 7. The mechanisms regulating its abnormal growth and metastasis are not fully understood. Transforming Growth Factor-Beta (TGF-β) has been described as both a negative prognostic indicator and a growth promoter in prostate cancer. The p21-Activated kinase 2 (Pak2) enzyme regulates growth and migration of normal cells and has been shown to be activated by TGF-β. My hypothesis proposes that Pak2 regulates the aberrant migratory properties of prostate cancer. Multiple prostate cancer cell lines, representing multiple stages in disease development were used to define protein and gene expression levels within the Pak2 signaling cascade. P-Merlin levels were used to determine Pak2 activity. There is a shift in the ratio of Pak2 stimulatory proteins with a dominance of CDC42 corresponding with disease progression. The ratio of Merlin to Erbin is altered in all prostate cancer cells. There is an increase in P-Merlin levels corresponding to progression of the disease, indicating an increase in basal Pak2 activity. Pak2 inhibition blocked TGF-β promoted migration in highly metastatic prostate cancer cells PC-3 and DU145. These results demonstrate the Pak2 signaling pathway is not only aberrantly active but that regulates TGF-β induced migration in prostate cancer." @default.
- W2922987091 created "2019-04-01" @default.
- W2922987091 creator A5054273046 @default.
- W2922987091 date "2017-05-01" @default.
- W2922987091 modified "2023-09-23" @default.
- W2922987091 title "Characterization of regulatory proteins within the Pak2 signaling pathway on prostate cancer migration" @default.
- W2922987091 cites W11138111 @default.
- W2922987091 cites W1534406877 @default.
- W2922987091 cites W1551498481 @default.
- W2922987091 cites W1590842919 @default.
- W2922987091 cites W1857101486 @default.
- W2922987091 cites W1914050750 @default.
- W2922987091 cites W1963767618 @default.
- W2922987091 cites W1963935560 @default.
- W2922987091 cites W1968538228 @default.
- W2922987091 cites W1969393277 @default.
- W2922987091 cites W1970094818 @default.
- W2922987091 cites W1972383646 @default.
- W2922987091 cites W1973268693 @default.
- W2922987091 cites W1975577875 @default.
- W2922987091 cites W1976718543 @default.
- W2922987091 cites W1979346765 @default.
- W2922987091 cites W1980516263 @default.
- W2922987091 cites W1983628734 @default.
- W2922987091 cites W1988268462 @default.
- W2922987091 cites W1992239016 @default.
- W2922987091 cites W1992468405 @default.
- W2922987091 cites W1994898579 @default.
- W2922987091 cites W2004542452 @default.
- W2922987091 cites W2005252392 @default.
- W2922987091 cites W2005591572 @default.
- W2922987091 cites W2007473681 @default.
- W2922987091 cites W2008537833 @default.
- W2922987091 cites W2015169702 @default.
- W2922987091 cites W2018836208 @default.
- W2922987091 cites W2019050177 @default.
- W2922987091 cites W2027636469 @default.
- W2922987091 cites W2027810531 @default.
- W2922987091 cites W2029976610 @default.
- W2922987091 cites W2030366802 @default.
- W2922987091 cites W2031036670 @default.
- W2922987091 cites W2031383072 @default.
- W2922987091 cites W2041421563 @default.
- W2922987091 cites W2044399712 @default.
- W2922987091 cites W2050542154 @default.
- W2922987091 cites W2057161685 @default.
- W2922987091 cites W2059072734 @default.
- W2922987091 cites W2060020667 @default.
- W2922987091 cites W2060797107 @default.
- W2922987091 cites W2061385217 @default.
- W2922987091 cites W2063011414 @default.
- W2922987091 cites W2063639626 @default.
- W2922987091 cites W2064117760 @default.
- W2922987091 cites W2064293531 @default.
- W2922987091 cites W2066419333 @default.
- W2922987091 cites W2066845679 @default.
- W2922987091 cites W2079337167 @default.
- W2922987091 cites W2080006316 @default.
- W2922987091 cites W2083713591 @default.
- W2922987091 cites W2085040862 @default.
- W2922987091 cites W2090369455 @default.
- W2922987091 cites W2096071102 @default.
- W2922987091 cites W2097930500 @default.
- W2922987091 cites W2099361912 @default.
- W2922987091 cites W2101791298 @default.
- W2922987091 cites W2103164402 @default.
- W2922987091 cites W2104308710 @default.
- W2922987091 cites W2105445695 @default.
- W2922987091 cites W2107363136 @default.
- W2922987091 cites W2111704207 @default.
- W2922987091 cites W2111778006 @default.
- W2922987091 cites W2117367533 @default.
- W2922987091 cites W2118164479 @default.
- W2922987091 cites W2124281312 @default.
- W2922987091 cites W2128021675 @default.
- W2922987091 cites W2129124145 @default.
- W2922987091 cites W2129191533 @default.
- W2922987091 cites W2129277563 @default.
- W2922987091 cites W2134073082 @default.
- W2922987091 cites W2136280424 @default.
- W2922987091 cites W2137280750 @default.
- W2922987091 cites W2138938916 @default.
- W2922987091 cites W2140016888 @default.
- W2922987091 cites W2146378617 @default.
- W2922987091 cites W2147018670 @default.
- W2922987091 cites W2150418339 @default.
- W2922987091 cites W2151487166 @default.
- W2922987091 cites W2154608911 @default.
- W2922987091 cites W2161340336 @default.
- W2922987091 cites W2163997162 @default.
- W2922987091 cites W2168890170 @default.
- W2922987091 cites W2199765576 @default.
- W2922987091 cites W2200965921 @default.
- W2922987091 cites W2206283434 @default.
- W2922987091 cites W2208898580 @default.
- W2922987091 cites W2214508683 @default.
- W2922987091 cites W2515433063 @default.
- W2922987091 cites W91582749 @default.
- W2922987091 hasPublicationYear "2017" @default.
- W2922987091 type Work @default.