FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922989408> ?p ?o ?g. }

• W2922989408 abstract "The introduction of the classification of brain tumours based on their DNA methylation profile has significantly changed the diagnostic approach for cases with ambiguous histology, non-informative or contradictory molecular profiles or for entities where methylation profiling provides useful information for patient risk stratification, for example in medulloblastoma and ependymoma. We present our experience that combines a conventional molecular diagnostic approach with the complementary use of a DNA methylation-based classification tool, for adult brain tumours originating from local as well as national referrals. We report the frequency of IDH mutations in a large cohort of nearly 1550 patients, EGFR amplifications in almost 1900 IDH-wildtype glioblastomas, and histone mutations in 70 adult gliomas. We demonstrate how additional methylation-based classification has changed and improved our diagnostic approach. Of the 325 cases referred for methylome testing, 179 (56%) had a calibrated score of 0.84 and higher and were included in the evaluation. In these 179 samples, the diagnosis was changed in 45 (25%), refined in 86 (48%) and confirmed in 44 cases (25%). In addition, the methylation arrays contain copy number information that usefully complements the methylation profile. For example, EGFR amplification which is 95% concordant with our Real-Time PCR-based copy number assays. We propose here a diagnostic algorithm that integrates histology, conventional molecular tests and methylation arrays." @default.
• W2922989408 created "2019-04-01" @default.
• W2922989408 creator A5005354758 @default.
• W2922989408 creator A5025751964 @default.
• W2922989408 creator A5029113835 @default.
• W2922989408 creator A5039647180 @default.
• W2922989408 creator A5041096535 @default.
• W2922989408 creator A5052657395 @default.
• W2922989408 creator A5063134863 @default.
• W2922989408 creator A5064456190 @default.
• W2922989408 creator A5090815387 @default.
• W2922989408 creator A5091294404 @default.
• W2922989408 date "2019-02-20" @default.
• W2922989408 modified "2023-10-14" @default.
• W2922989408 title "Methylation array profiling of adult brain tumours: diagnostic outcomes in a large, single centre" @default.
• W2922989408 cites W1836650925 @default.
• W2922989408 cites W1949037014 @default.
• W2922989408 cites W1964609356 @default.
• W2922989408 cites W1997502785 @default.
• W2922989408 cites W2011570504 @default.
• W2922989408 cites W2028643362 @default.
• W2922989408 cites W2033130827 @default.
• W2922989408 cites W2038924704 @default.
• W2922989408 cites W2040584053 @default.
• W2922989408 cites W2048796627 @default.
• W2922989408 cites W2076644266 @default.
• W2922989408 cites W2101775250 @default.
• W2922989408 cites W2105348749 @default.
• W2922989408 cites W2114570899 @default.
• W2922989408 cites W2120963683 @default.
• W2922989408 cites W2122404743 @default.
• W2922989408 cites W2127643721 @default.
• W2922989408 cites W2146267855 @default.
• W2922989408 cites W2165541556 @default.
• W2922989408 cites W2168784615 @default.
• W2922989408 cites W2169301285 @default.
• W2922989408 cites W2210813576 @default.
• W2922989408 cites W2263522623 @default.
• W2922989408 cites W2270206867 @default.
• W2922989408 cites W2286322195 @default.
• W2922989408 cites W2329293517 @default.
• W2922989408 cites W2366536035 @default.
• W2922989408 cites W2553451383 @default.
• W2922989408 cites W2598133926 @default.
• W2922989408 cites W2618958001 @default.
• W2922989408 cites W2724967061 @default.
• W2922989408 cites W2781062741 @default.
• W2922989408 cites W2787816121 @default.
• W2922989408 cites W2791150552 @default.
• W2922989408 cites W2793833695 @default.
• W2922989408 cites W2802818144 @default.
• W2922989408 cites W2803972431 @default.
• W2922989408 cites W2811036728 @default.
• W2922989408 cites W2891763428 @default.
• W2922989408 cites W2897033359 @default.
• W2922989408 cites W564708804 @default.
• W2922989408 cites W571060166 @default.
• W2922989408 doi "https://doi.org/10.1186/s40478-019-0668-8" @default.
• W2922989408 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6381711" @default.
• W2922989408 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30786920" @default.
• W2922989408 hasPublicationYear "2019" @default.
• W2922989408 type Work @default.
• W2922989408 sameAs 2922989408 @default.
• W2922989408 citedByCount "92" @default.
• W2922989408 countsByYear W29229894082019 @default.
• W2922989408 countsByYear W29229894082020 @default.
• W2922989408 countsByYear W29229894082021 @default.
• W2922989408 countsByYear W29229894082022 @default.
• W2922989408 countsByYear W29229894082023 @default.
• W2922989408 crossrefType "journal-article" @default.
• W2922989408 hasAuthorship W2922989408A5005354758 @default.
• W2922989408 hasAuthorship W2922989408A5025751964 @default.
• W2922989408 hasAuthorship W2922989408A5029113835 @default.
• W2922989408 hasAuthorship W2922989408A5039647180 @default.
• W2922989408 hasAuthorship W2922989408A5041096535 @default.
• W2922989408 hasAuthorship W2922989408A5052657395 @default.
• W2922989408 hasAuthorship W2922989408A5063134863 @default.
• W2922989408 hasAuthorship W2922989408A5064456190 @default.
• W2922989408 hasAuthorship W2922989408A5090815387 @default.
• W2922989408 hasAuthorship W2922989408A5091294404 @default.
• W2922989408 hasBestOaLocation W29229894081 @default.
• W2922989408 hasConcept C104317684 @default.
• W2922989408 hasConcept C142724271 @default.
• W2922989408 hasConcept C143998085 @default.
• W2922989408 hasConcept C150194340 @default.
• W2922989408 hasConcept C190727270 @default.
• W2922989408 hasConcept C2779130545 @default.
• W2922989408 hasConcept C2780789225 @default.
• W2922989408 hasConcept C2781432949 @default.
• W2922989408 hasConcept C33288867 @default.
• W2922989408 hasConcept C54355233 @default.
• W2922989408 hasConcept C552990157 @default.
• W2922989408 hasConcept C60644358 @default.
• W2922989408 hasConcept C70721500 @default.
• W2922989408 hasConcept C71924100 @default.
• W2922989408 hasConcept C86803240 @default.
• W2922989408 hasConceptScore W2922989408C104317684 @default.
• W2922989408 hasConceptScore W2922989408C142724271 @default.
• W2922989408 hasConceptScore W2922989408C143998085 @default.
• W2922989408 hasConceptScore W2922989408C150194340 @default.

• next