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• W2922992011 abstract "We use a two and three-dimensional cellular Potts model (CPM) to represent the behaviour of an epithelial cell layer and describe its dynamics in response to a microscopic wound and a single modified cell. The energy function of the CPM describes mechanical properties of the cells and it was found that the interaction between contractile tension on cell membranes and the adhesion interactions between cells and substrate surfaces play an important role in the cell morphology, the closure of a wound and extrusion of a cell in the monolayer. Our results suggest that, depending on the balance between cell-cell adhesion and junctional tension, mechanics of the monolayer can either correspond to a hard or a soft regime that determines cell morphology and polygonal organisation in the monolayer.The presence of a wound in a hard regime, where junctional tension is significant, or soft regime, where cell-cell adhesion dominates, can determine whether a wound will close or not. Theoretical approximations and simulations allowed us to determine the thresholds in the values of cell-cell adhesion and initial wound size that allow the system to lead to wound closure. Additional mechanisms, such as adhesion between the substrate and cells and apical perimeter contraction can shift where the threshold between the hard and soft regimes occurs. Overall, our results suggest that changes in the balance between contraction and adhesion around the site of injury determine whether or not non-monotonous wound closure occurs.The extrusion of a single cell is only present if that cell adhesion and contractile tension is modified to differ from that of its neighbours and the interaction of the neighbouring cells' cell-cell adhesion and contraction lead to remove the cell from the monolayer and close of the void left by the modified cell. Theoretical approximations and simulations give a clearer picture of the interaction between different mechanisms and the condition of which the cell needs to be extruded." @default.
• W2922992011 created "2019-04-01" @default.
• W2922992011 creator A5069278322 @default.
• W2922992011 date "2019-03-05" @default.
• W2922992011 modified "2023-09-24" @default.
• W2922992011 title "Simulating the collective behaviour of a monolayer of epithelial cells using a cellular Potts model" @default.
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• W2922992011 doi "https://doi.org/10.14264/uql.2019.102" @default.
• W2922992011 hasPublicationYear "2019" @default.
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