Matches in SemOpenAlex for { <https://semopenalex.org/work/W2923017843> ?p ?o ?g. }
Showing items 1 to 55 of
55
with 100 items per page.
- W2923017843 abstract "Chemistry of heterocyclic compounds is one of the most popular sector in organic chemistry. Scientists allocate among them a class of derivatives of 1,2,4-triazole. This class of compounds attracts attention his broad spectrum of biological activity. There are antiviral, anti-inflammatory, anti-tubercular, antimicrobial, antioxidant, actoprotective, anti-cancer and other activities. The derivatives of 1,2,4-triazole have one more important advantage. It is low toxicity. This properties do this class of derivatives promising for researches their chemical structure and biological activity and purposeful search of biologically active substances.
 The purpose of the work is synthesis of 5-(4-(tert-butyl)phenyl)-4-((R)amino)-4H-1,2,4-triazoles-3-thiols from appropriate ylidene derivatives of 4-amino-5-(4 (tert-butyl)phenyl)-4H-1,2,4-triazoles-3-thiol and research of their physical and chemical properties.
 The objects of research were 10 new compounds, derivatives of 4-amino-5-(4-(tert-butyl)phenyl)-4H-1,2,4-triazoles-3-thiol. These compounds are the crystal substances which are odorless, insoluble in water and soluble in organic solvents. Investigation of the physical and chemical properties of this compounds was carried out according to the methods listed in the State Pharmacopoeia of Ukraine. The melting temperature of synthesized compounds was determined by device OptiMelt Stanford Research Systems MPA100. The structure of the compound was confirmed by 1H-NMR spectroscopy (Mercury 400) and gas chromatography-mass spectrometry (Agilent 1260 Infinity HPLC).
 10 new compounds, derivatives of 4-amino-5-(4-(tert-butyl)phenyl)-4H-1,2,4-triazoles-3-thiol, were synthesized in a study. The chemical structure of the new compounds was confirmed by modern instrumental methods of analysis. Results of the done work can be use in the future search of biologically active substances." @default.
- W2923017843 created "2019-04-01" @default.
- W2923017843 creator A5002110192 @default.
- W2923017843 creator A5029544461 @default.
- W2923017843 creator A5059920970 @default.
- W2923017843 date "2018-08-14" @default.
- W2923017843 modified "2023-10-14" @default.
- W2923017843 title "Synthesis and structural features of 5-(4-(tert-butyl) phenyl)-4-((R)amino)-4H-1,2,4-triazole-3-thiols" @default.
- W2923017843 doi "https://doi.org/10.32352/0367-3057.6.16.03" @default.
- W2923017843 hasPublicationYear "2018" @default.
- W2923017843 type Work @default.
- W2923017843 sameAs 2923017843 @default.
- W2923017843 citedByCount "0" @default.
- W2923017843 crossrefType "journal-article" @default.
- W2923017843 hasAuthorship W2923017843A5002110192 @default.
- W2923017843 hasAuthorship W2923017843A5029544461 @default.
- W2923017843 hasAuthorship W2923017843A5059920970 @default.
- W2923017843 hasBestOaLocation W29230178431 @default.
- W2923017843 hasConcept C116073593 @default.
- W2923017843 hasConcept C175528265 @default.
- W2923017843 hasConcept C178790620 @default.
- W2923017843 hasConcept C185592680 @default.
- W2923017843 hasConcept C202751555 @default.
- W2923017843 hasConcept C21951064 @default.
- W2923017843 hasConcept C2780020378 @default.
- W2923017843 hasConcept C2781324293 @default.
- W2923017843 hasConcept C4937899 @default.
- W2923017843 hasConcept C55493867 @default.
- W2923017843 hasConceptScore W2923017843C116073593 @default.
- W2923017843 hasConceptScore W2923017843C175528265 @default.
- W2923017843 hasConceptScore W2923017843C178790620 @default.
- W2923017843 hasConceptScore W2923017843C185592680 @default.
- W2923017843 hasConceptScore W2923017843C202751555 @default.
- W2923017843 hasConceptScore W2923017843C21951064 @default.
- W2923017843 hasConceptScore W2923017843C2780020378 @default.
- W2923017843 hasConceptScore W2923017843C2781324293 @default.
- W2923017843 hasConceptScore W2923017843C4937899 @default.
- W2923017843 hasConceptScore W2923017843C55493867 @default.
- W2923017843 hasLocation W29230178431 @default.
- W2923017843 hasOpenAccess W2923017843 @default.
- W2923017843 hasPrimaryLocation W29230178431 @default.
- W2923017843 hasRelatedWork W2027005679 @default.
- W2923017843 hasRelatedWork W2329028845 @default.
- W2923017843 hasRelatedWork W2604336025 @default.
- W2923017843 hasRelatedWork W2923017843 @default.
- W2923017843 hasRelatedWork W2950489693 @default.
- W2923017843 hasRelatedWork W2951982830 @default.
- W2923017843 hasRelatedWork W3199365510 @default.
- W2923017843 hasRelatedWork W3202333443 @default.
- W2923017843 hasRelatedWork W3215767296 @default.
- W2923017843 hasRelatedWork W2738691209 @default.
- W2923017843 isParatext "false" @default.
- W2923017843 isRetracted "false" @default.
- W2923017843 magId "2923017843" @default.
- W2923017843 workType "article" @default.