FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2923032795> ?p ?o ?g. }

• W2923032795 endingPage "404" @default.
• W2923032795 startingPage "393" @default.
• W2923032795 abstract "Immune system evasion is essential for tumor cell survival and is mediated by the immunosuppressive tumor microenvironment and the activation of inhibitory immune checkpoints. While immune checkpoint-based therapy yielded impressive results in several advanced solid malignancies such as melanoma and non-small cell lung cancer, its role in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) is still evolving. Areas covered: Here we review the immunology in the tumor microenvironment in the bone marrow and discuss the current preclinical and clinical data for immune checkpoint-based therapy in myeloid neoplasms. Expert commentary: Clinical trials of immune checkpoint inhibitors (ICI) in AML and MDS are still in early stages and reported results so far have been modest especially for monotherapy use in the refractory settings. However, there are preliminary data for synergistic effects for combination of multiple ICI with hypomethylating agents and conventional chemotherapy. ICI might also be effective in eradicating minimal residual disease and to prevent relapse following induction chemotherapy or hematopoietic stem cell transplant. Additional trials to provide insight into the efficacy and safety profile of immune checkpoint-based therapy, its optimal timing and potential combination with other types of therapy as well as identification of predictive biomarkers are needed." @default.
• W2923032795 created "2019-04-01" @default.
• W2923032795 creator A5013969487 @default.
• W2923032795 creator A5067521829 @default.
• W2923032795 creator A5084588977 @default.
• W2923032795 date "2019-03-19" @default.
• W2923032795 modified "2023-10-14" @default.
• W2923032795 title "Immune checkpoint-based therapy in myeloid malignancies: a promise yet to be fulfilled" @default.
• W2923032795 cites W1544829530 @default.
• W2923032795 cites W1574888913 @default.
• W2923032795 cites W1661441964 @default.
• W2923032795 cites W1678477267 @default.
• W2923032795 cites W1763981524 @default.
• W2923032795 cites W1827923022 @default.
• W2923032795 cites W1916138910 @default.
• W2923032795 cites W1917543987 @default.
• W2923032795 cites W1953890763 @default.
• W2923032795 cites W1962016368 @default.
• W2923032795 cites W1971641493 @default.
• W2923032795 cites W1975516216 @default.
• W2923032795 cites W1976105607 @default.
• W2923032795 cites W1983973479 @default.
• W2923032795 cites W1997731331 @default.
• W2923032795 cites W1998256451 @default.
• W2923032795 cites W2000112238 @default.
• W2923032795 cites W2001732035 @default.
• W2923032795 cites W2002478729 @default.
• W2923032795 cites W2005401733 @default.
• W2923032795 cites W2016983859 @default.
• W2923032795 cites W2019525376 @default.
• W2923032795 cites W2020242768 @default.
• W2923032795 cites W2021588881 @default.
• W2923032795 cites W2022952467 @default.
• W2923032795 cites W2028824678 @default.
• W2923032795 cites W2029299243 @default.
• W2923032795 cites W2032554897 @default.
• W2923032795 cites W2035740887 @default.
• W2923032795 cites W2044224425 @default.
• W2923032795 cites W2048797618 @default.
• W2923032795 cites W2053999133 @default.
• W2923032795 cites W2055056105 @default.
• W2923032795 cites W2058043365 @default.
• W2923032795 cites W2059123794 @default.
• W2923032795 cites W2062745346 @default.
• W2923032795 cites W2064837930 @default.
• W2923032795 cites W2067948267 @default.
• W2923032795 cites W2070211690 @default.
• W2923032795 cites W2071523891 @default.
• W2923032795 cites W2071908402 @default.
• W2923032795 cites W2095864883 @default.
• W2923032795 cites W2097126393 @default.
• W2923032795 cites W2097995306 @default.
• W2923032795 cites W2103746815 @default.
• W2923032795 cites W2104347254 @default.
• W2923032795 cites W2104885590 @default.
• W2923032795 cites W2109150359 @default.
• W2923032795 cites W2109485845 @default.
• W2923032795 cites W2115721890 @default.
• W2923032795 cites W2117247812 @default.
• W2923032795 cites W2117692326 @default.
• W2923032795 cites W2118471749 @default.
• W2923032795 cites W2118546263 @default.
• W2923032795 cites W2118725525 @default.
• W2923032795 cites W2125616358 @default.
• W2923032795 cites W2126448969 @default.
• W2923032795 cites W2128035403 @default.
• W2923032795 cites W2130338247 @default.
• W2923032795 cites W2130473166 @default.
• W2923032795 cites W2130822830 @default.
• W2923032795 cites W2137074525 @default.
• W2923032795 cites W2139276258 @default.
• W2923032795 cites W2156353875 @default.
• W2923032795 cites W2157326360 @default.
• W2923032795 cites W2168631000 @default.
• W2923032795 cites W2170513194 @default.
• W2923032795 cites W2265134611 @default.
• W2923032795 cites W2289712604 @default.
• W2923032795 cites W2412725897 @default.
• W2923032795 cites W2465734185 @default.
• W2923032795 cites W2490824689 @default.
• W2923032795 cites W2510286120 @default.
• W2923032795 cites W2521479161 @default.
• W2923032795 cites W2546632559 @default.
• W2923032795 cites W2550646651 @default.
• W2923032795 cites W2558231679 @default.
• W2923032795 cites W2559063149 @default.
• W2923032795 cites W2560367415 @default.
• W2923032795 cites W2566018578 @default.
• W2923032795 cites W2566677727 @default.
• W2923032795 cites W2570232776 @default.
• W2923032795 cites W2572174216 @default.
• W2923032795 cites W2590534615 @default.
• W2923032795 cites W2592575609 @default.
• W2923032795 cites W2593059553 @default.
• W2923032795 cites W2594496276 @default.
• W2923032795 cites W2594967879 @default.
• W2923032795 cites W2598169592 @default.
• W2923032795 cites W2604291631 @default.

• next