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• W2923087300 abstract "Foxp3+ regulatory T cells (Tregs) play a major role in acquired immune tolerance to allogenic transplants. Their suppressive activity is thought to require T cell receptor (TCR)-driven antigen recognition; little, however, is known about the fraction of Tregs able to recognize alloantigens within this T cell subset primarily educated against self-antigens. Performing transfer experiments of Tregs or conventional T cells (Tconv) into both lymphoreplete and lymphopenic mice, we observed a similarly high proportion of cells signaling through their TCR and proliferating in allogenic hosts. Furthermore, using an in vivo proliferation assay with limited T cell numbers infused into lymphopenic mice, we found that the overall frequency of alloreactive Tregs was similar if not higher to that of alloreactive Tconv. Overall our study highlights a noticeably high level of alloreactive Foxp3+ regulatory T cells accounting for their predominant role in transplantation tolerance." @default.
• W2923087300 created "2019-04-01" @default.
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• W2923087300 date "2019-03-19" @default.
• W2923087300 modified "2023-10-13" @default.
• W2923087300 title "Foxp3+ Regulatory and Conventional CD4+ T Cells Display Similarly High Frequencies of Alloantigen-Reactive Cells" @default.
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• W2923087300 doi "https://doi.org/10.3389/fimmu.2019.00521" @default.
• W2923087300 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6434998" @default.
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