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- W29230890 endingPage "223" @default.
- W29230890 startingPage "203" @default.
- W29230890 abstract "Unlike pluripotent stem cells in the early embryo, many types of somatic stem cells in the adult, such as hematopoietic, neural, and hair follicle stem cells, appear to have a limited life span. There are a number of different intrinsic and extrinsic factors that can affect the regulation of somatic stem cell life span, including the accumulation of DNA damage, oxidative stress from reactive oxygen species, the attrition of telomeres, aberrant changes in gene expression driven by age-related epigenetic shifts, and loss of function of the stem cell niche with age. There are also a number of potential events that define the end-point to stem cell life span, namely cell senescence, apoptosis, terminal differentiation, and tumorigenic transformation. The principal factors affecting the rate of aging in a somatic stem cell as well as the mechanism of life span termination are dependent on the type of stem cell. The development of new methods to extend or attenuate somatic stem cell life span holds substantial promise as effective means to treat the age-related or disease-specific decline in numbers of certain stem cells, or to eliminate cancer stem cells as an anticancer therapy, respectively." @default.
- W29230890 created "2016-06-24" @default.
- W29230890 creator A5056586542 @default.
- W29230890 creator A5069643898 @default.
- W29230890 date "2011-01-01" @default.
- W29230890 modified "2023-10-03" @default.
- W29230890 title "Regulation of Life Span in Adult Stem Cells" @default.
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