Matches in SemOpenAlex for { <https://semopenalex.org/work/W2923109630> ?p ?o ?g. }
- W2923109630 endingPage "7720" @default.
- W2923109630 startingPage "7707" @default.
- W2923109630 abstract "Peroxisome proliferator-activated receptor (PPAR)-γ has been implicated as a key player in the regulation of adiponectin levels via both transcriptional and posttranscriptional mechanisms. Herein, we show that PPAR-γ interacts with human antigen R (HuR) and that the PPAR-γ-HuR complex dissociates following activation of PPAR-γ by rosiglitazone, a specific ligand of PPAR-γ. This rosiglitazone-dependent dissociation of HuR from PPAR-γ leads to nucleocytoplasmic shuttling of HuR and its binding to the 3'-UTR of adiponectin mRNA. PPAR-γ with H321A and H447A double mutation (PPAR-γH321/447A), a mutant lacking ligand-binding activity, impaired HuR dissociation from the PPAR-γ-HuR complex, resulting in reduced nucleocytoplasmic shuttling, even in the presence of rosiglitazone. Consequently, rosiglitazone up-regulated adiponectin levels by modulating the stability of adiponectin mRNA, whereas these effects were abolished by HuR ablation or blocked in cells expressing the PPAR-γH321/447A mutant, indicating that the interaction of PPAR-γ and HuR is a critical event during adiponectin expression. Taken together, the findings demonstrate a novel mechanism for regulating adiponectin expression at the posttranscriptional level and suggest that ligand-mediated activation of PPAR-γ to interfere with interaction of HuR could offer a therapeutic strategy for inflammation-associated diseases that involve decreased adiponectin mRNA stability.-Hwang, J. S., Lee, W. J., Hur, J., Lee, H. G., Kim, E., Lee, G. H., Choi, M.-J., Lim, D.-S., Paek, K. S., Seo, H. G. Rosiglitazone-dependent dissociation of HuR from PPAR-γ regulates adiponectin expression at the posttranscriptional level." @default.
- W2923109630 created "2019-04-01" @default.
- W2923109630 creator A5006985836 @default.
- W2923109630 creator A5014493578 @default.
- W2923109630 creator A5020158238 @default.
- W2923109630 creator A5034021534 @default.
- W2923109630 creator A5047618827 @default.
- W2923109630 creator A5053495977 @default.
- W2923109630 creator A5057217216 @default.
- W2923109630 creator A5075620077 @default.
- W2923109630 creator A5077285430 @default.
- W2923109630 creator A5085877215 @default.
- W2923109630 date "2019-03-21" @default.
- W2923109630 modified "2023-10-15" @default.
- W2923109630 title "Rosiglitazone‐dependent dissociation of HuR from PPAR‐γ regulates adiponectin expression at the posttranscriptional level" @default.
- W2923109630 cites W1482159339 @default.
- W2923109630 cites W1947214230 @default.
- W2923109630 cites W1964631969 @default.
- W2923109630 cites W1971542373 @default.
- W2923109630 cites W1982925662 @default.
- W2923109630 cites W2002257350 @default.
- W2923109630 cites W2002415424 @default.
- W2923109630 cites W2003230246 @default.
- W2923109630 cites W2023459898 @default.
- W2923109630 cites W2024276071 @default.
- W2923109630 cites W2026088200 @default.
- W2923109630 cites W2027149291 @default.
- W2923109630 cites W2033665221 @default.
- W2923109630 cites W2038393880 @default.
- W2923109630 cites W2050400795 @default.
- W2923109630 cites W2054041854 @default.
- W2923109630 cites W2054277796 @default.
- W2923109630 cites W2058691182 @default.
- W2923109630 cites W2061730456 @default.
- W2923109630 cites W2062804183 @default.
- W2923109630 cites W2064513293 @default.
- W2923109630 cites W2069172141 @default.
- W2923109630 cites W2079596789 @default.
- W2923109630 cites W2089687829 @default.
- W2923109630 cites W2091416361 @default.
- W2923109630 cites W2096259566 @default.
- W2923109630 cites W2099518931 @default.
- W2923109630 cites W2101304778 @default.
- W2923109630 cites W2105448220 @default.
- W2923109630 cites W2106447612 @default.
- W2923109630 cites W2110919070 @default.
- W2923109630 cites W2117616262 @default.
- W2923109630 cites W2117854326 @default.
- W2923109630 cites W2118723490 @default.
- W2923109630 cites W2120549411 @default.
- W2923109630 cites W2121055029 @default.
- W2923109630 cites W2121140284 @default.
- W2923109630 cites W2125058279 @default.
- W2923109630 cites W2127934772 @default.
- W2923109630 cites W2131702141 @default.
- W2923109630 cites W2139509343 @default.
- W2923109630 cites W2151896530 @default.
- W2923109630 cites W2152897468 @default.
- W2923109630 cites W2162702313 @default.
- W2923109630 cites W2163160776 @default.
- W2923109630 cites W2163678936 @default.
- W2923109630 cites W2163785571 @default.
- W2923109630 cites W2164427376 @default.
- W2923109630 cites W2168760462 @default.
- W2923109630 cites W2538886154 @default.
- W2923109630 cites W2784914640 @default.
- W2923109630 cites W4238497443 @default.
- W2923109630 cites W610568945 @default.
- W2923109630 cites W79782691 @default.
- W2923109630 doi "https://doi.org/10.1096/fj.201802643r" @default.
- W2923109630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30897345" @default.
- W2923109630 hasPublicationYear "2019" @default.
- W2923109630 type Work @default.
- W2923109630 sameAs 2923109630 @default.
- W2923109630 citedByCount "8" @default.
- W2923109630 countsByYear W29231096302020 @default.
- W2923109630 countsByYear W29231096302021 @default.
- W2923109630 countsByYear W29231096302022 @default.
- W2923109630 countsByYear W29231096302023 @default.
- W2923109630 crossrefType "journal-article" @default.
- W2923109630 hasAuthorship W2923109630A5006985836 @default.
- W2923109630 hasAuthorship W2923109630A5014493578 @default.
- W2923109630 hasAuthorship W2923109630A5020158238 @default.
- W2923109630 hasAuthorship W2923109630A5034021534 @default.
- W2923109630 hasAuthorship W2923109630A5047618827 @default.
- W2923109630 hasAuthorship W2923109630A5053495977 @default.
- W2923109630 hasAuthorship W2923109630A5057217216 @default.
- W2923109630 hasAuthorship W2923109630A5075620077 @default.
- W2923109630 hasAuthorship W2923109630A5077285430 @default.
- W2923109630 hasAuthorship W2923109630A5085877215 @default.
- W2923109630 hasBestOaLocation W29231096301 @default.
- W2923109630 hasConcept C104317684 @default.
- W2923109630 hasConcept C105580179 @default.
- W2923109630 hasConcept C126322002 @default.
- W2923109630 hasConcept C127078168 @default.
- W2923109630 hasConcept C127561419 @default.
- W2923109630 hasConcept C134018914 @default.
- W2923109630 hasConcept C143065580 @default.