Matches in SemOpenAlex for { <https://semopenalex.org/work/W2923138898> ?p ?o ?g. }
- W2923138898 endingPage "1203" @default.
- W2923138898 startingPage "1203" @default.
- W2923138898 abstract "Lignans from Schisandra chinensis (Turcz.) Baill can ameliorate cognitive impairment in animals with Alzheimer's disease (AD). However, the metabolism of absorbed ingredients and the potential targets of the lignans from S. chinensis in animals with AD have not been systematically investigated. Therefore, for the first time, we performed an in-vivo ingredient analysis and implemented a target-network pharmacology strategy to assess the effects of lignans from S. chinensis in rats with AD. Ten absorbed prototype constituents and 39 metabolites were identified or tentatively characterized in the plasma of dosed rats with AD using ultra high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Based on the results of analysis of the effective constituents in vivo, the potential therapeutic mechanism of the effective constituents in the rats with AD was investigated using a target-network pharmacology approach and independent experimental validation. The results showed that the treatment effects of lignans from S. chinensis on cognitive impairment might involve the regulation of amyloid precursor protein metabolism, neurofibrillary tangles, neurotransmitter metabolism, inflammatory response, and antioxidant system. Overall, we identified the effective components of lignans in S. chinensis that can improve the cognitive impairment induced by AD and proposed potential therapeutic metabolic pathways. The results might serve as the basis for a fundamental strategy to explore effective therapeutic drugs to treat AD." @default.
- W2923138898 created "2019-04-01" @default.
- W2923138898 creator A5000698319 @default.
- W2923138898 creator A5008391277 @default.
- W2923138898 creator A5025993925 @default.
- W2923138898 creator A5026941428 @default.
- W2923138898 creator A5036961411 @default.
- W2923138898 creator A5037920295 @default.
- W2923138898 creator A5043715354 @default.
- W2923138898 creator A5054464310 @default.
- W2923138898 creator A5060341807 @default.
- W2923138898 creator A5079681219 @default.
- W2923138898 creator A5088872065 @default.
- W2923138898 date "2019-03-27" @default.
- W2923138898 modified "2023-10-10" @default.
- W2923138898 title "Systematically Characterize the Anti-Alzheimer's Disease Mechanism of Lignans from S. chinensis based on In-Vivo Ingredient Analysis and Target-Network Pharmacology Strategy by UHPLC–Q-TOF-MS" @default.
- W2923138898 cites W1270834676 @default.
- W2923138898 cites W1515328725 @default.
- W2923138898 cites W1528790659 @default.
- W2923138898 cites W1547782763 @default.
- W2923138898 cites W1554862107 @default.
- W2923138898 cites W1621566533 @default.
- W2923138898 cites W1656193908 @default.
- W2923138898 cites W1662397621 @default.
- W2923138898 cites W166614110 @default.
- W2923138898 cites W1682771183 @default.
- W2923138898 cites W1807531660 @default.
- W2923138898 cites W1923384484 @default.
- W2923138898 cites W1966103710 @default.
- W2923138898 cites W1966652886 @default.
- W2923138898 cites W1973026127 @default.
- W2923138898 cites W1991723017 @default.
- W2923138898 cites W1993352447 @default.
- W2923138898 cites W1993617137 @default.
- W2923138898 cites W1994679297 @default.
- W2923138898 cites W1995079654 @default.
- W2923138898 cites W1999667172 @default.
- W2923138898 cites W2001405361 @default.
- W2923138898 cites W2001934912 @default.
- W2923138898 cites W2010383783 @default.
- W2923138898 cites W2014886338 @default.
- W2923138898 cites W2018806438 @default.
- W2923138898 cites W2019074857 @default.
- W2923138898 cites W2020941408 @default.
- W2923138898 cites W2022659965 @default.
- W2923138898 cites W2023465724 @default.
- W2923138898 cites W2024186664 @default.
- W2923138898 cites W2030065832 @default.
- W2923138898 cites W2034537627 @default.
- W2923138898 cites W2034887433 @default.
- W2923138898 cites W2038167014 @default.
- W2923138898 cites W2042952308 @default.
- W2923138898 cites W2044894914 @default.
- W2923138898 cites W2046556466 @default.
- W2923138898 cites W2048966170 @default.
- W2923138898 cites W2050051794 @default.
- W2923138898 cites W2050275393 @default.
- W2923138898 cites W2050897452 @default.
- W2923138898 cites W2052577790 @default.
- W2923138898 cites W2052850418 @default.
- W2923138898 cites W2054717744 @default.
- W2923138898 cites W2065286099 @default.
- W2923138898 cites W2070856983 @default.
- W2923138898 cites W2072552004 @default.
- W2923138898 cites W2076243086 @default.
- W2923138898 cites W2077000982 @default.
- W2923138898 cites W2079749054 @default.
- W2923138898 cites W2084776612 @default.
- W2923138898 cites W2091788870 @default.
- W2923138898 cites W2092598865 @default.
- W2923138898 cites W2103324311 @default.
- W2923138898 cites W2111078532 @default.
- W2923138898 cites W2116788801 @default.
- W2923138898 cites W2117573289 @default.
- W2923138898 cites W2123295289 @default.
- W2923138898 cites W2124679671 @default.
- W2923138898 cites W2126607520 @default.
- W2923138898 cites W2127582027 @default.
- W2923138898 cites W2127597456 @default.
- W2923138898 cites W2129692964 @default.
- W2923138898 cites W2130118447 @default.
- W2923138898 cites W2130625920 @default.
- W2923138898 cites W2131347449 @default.
- W2923138898 cites W2144003253 @default.
- W2923138898 cites W2146994504 @default.
- W2923138898 cites W2149021046 @default.
- W2923138898 cites W2151063521 @default.
- W2923138898 cites W2154473687 @default.
- W2923138898 cites W2156443053 @default.
- W2923138898 cites W2157248930 @default.
- W2923138898 cites W2165989868 @default.
- W2923138898 cites W2265231273 @default.
- W2923138898 cites W2323015725 @default.
- W2923138898 cites W2326500244 @default.
- W2923138898 cites W2401866878 @default.
- W2923138898 cites W2407146482 @default.
- W2923138898 cites W2527481200 @default.
- W2923138898 cites W2564704228 @default.