Matches in SemOpenAlex for { <https://semopenalex.org/work/W2923185775> ?p ?o ?g. }
- W2923185775 endingPage "869" @default.
- W2923185775 startingPage "857" @default.
- W2923185775 abstract "Spermatogonial stem cells (SSCs) are essential for spermatogenesis and male fertility. MicroRNAs (miRs) are key regulators of gene expression involved in self-renewal, differentiation, and apoptosis. However, the function and mechanisms of individual miR in regulating self-renewal and differentiation of SSCs remain unclear. Here, we report for the first time that miR-322 regulates self-renewal of SSCs. Functional assays revealed that miR-322 was essential for SSC self-renewal. Mechanistically, miR-322 promoted SSC self-renewal by targeting RASSF8 (ras association domain family 8). Moreover, the WNT/β-catenin signaling pathway was involved in the miR-322-mediated regulation. Furthermore, miR-322 overexpression increased GFRα1, ETV5 and PLZF expression but decreased STRA8, C-KIT and BCL6 expression. Our study provides not only a novel insight into molecular mechanisms regulating SSC self-renewal but also a basis for the diagnosis, treatment, and prevention of male infertility." @default.
- W2923185775 created "2019-04-01" @default.
- W2923185775 creator A5027371446 @default.
- W2923185775 creator A5036347970 @default.
- W2923185775 creator A5039229244 @default.
- W2923185775 creator A5079071782 @default.
- W2923185775 creator A5079962049 @default.
- W2923185775 date "2019-01-01" @default.
- W2923185775 modified "2023-10-03" @default.
- W2923185775 title "MicroRNA-322 Regulates Self-renewal of Mouse Spermatogonial Stem Cells through <i>Rassf8</i>" @default.
- W2923185775 cites W1480699894 @default.
- W2923185775 cites W1843736399 @default.
- W2923185775 cites W1981979988 @default.
- W2923185775 cites W1987414734 @default.
- W2923185775 cites W1991026868 @default.
- W2923185775 cites W1993245361 @default.
- W2923185775 cites W2000331857 @default.
- W2923185775 cites W2011612823 @default.
- W2923185775 cites W2021397187 @default.
- W2923185775 cites W2029040687 @default.
- W2923185775 cites W2034240230 @default.
- W2923185775 cites W2037979286 @default.
- W2923185775 cites W2041369934 @default.
- W2923185775 cites W2042500162 @default.
- W2923185775 cites W2046930479 @default.
- W2923185775 cites W2053834034 @default.
- W2923185775 cites W2059033739 @default.
- W2923185775 cites W2059382687 @default.
- W2923185775 cites W2063907721 @default.
- W2923185775 cites W2067924039 @default.
- W2923185775 cites W2070300493 @default.
- W2923185775 cites W2073738799 @default.
- W2923185775 cites W2084675240 @default.
- W2923185775 cites W2086809547 @default.
- W2923185775 cites W2091365246 @default.
- W2923185775 cites W2092018614 @default.
- W2923185775 cites W2101987836 @default.
- W2923185775 cites W2107449283 @default.
- W2923185775 cites W2113083989 @default.
- W2923185775 cites W2117533395 @default.
- W2923185775 cites W2119284420 @default.
- W2923185775 cites W2126768340 @default.
- W2923185775 cites W2127730759 @default.
- W2923185775 cites W2128996975 @default.
- W2923185775 cites W2142565421 @default.
- W2923185775 cites W2147898515 @default.
- W2923185775 cites W2153769630 @default.
- W2923185775 cites W2157822813 @default.
- W2923185775 cites W2167112938 @default.
- W2923185775 cites W2168405256 @default.
- W2923185775 cites W2254944169 @default.
- W2923185775 cites W2264123110 @default.
- W2923185775 cites W2319235871 @default.
- W2923185775 cites W2351333099 @default.
- W2923185775 cites W2488433037 @default.
- W2923185775 cites W2564406489 @default.
- W2923185775 cites W2567346568 @default.
- W2923185775 cites W2610038606 @default.
- W2923185775 cites W2620609617 @default.
- W2923185775 cites W2743047499 @default.
- W2923185775 cites W2800887739 @default.
- W2923185775 doi "https://doi.org/10.7150/ijbs.30611" @default.
- W2923185775 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6429012" @default.
- W2923185775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30906216" @default.
- W2923185775 hasPublicationYear "2019" @default.
- W2923185775 type Work @default.
- W2923185775 sameAs 2923185775 @default.
- W2923185775 citedByCount "25" @default.
- W2923185775 countsByYear W29231857752019 @default.
- W2923185775 countsByYear W29231857752020 @default.
- W2923185775 countsByYear W29231857752021 @default.
- W2923185775 countsByYear W29231857752022 @default.
- W2923185775 countsByYear W29231857752023 @default.
- W2923185775 crossrefType "journal-article" @default.
- W2923185775 hasAuthorship W2923185775A5027371446 @default.
- W2923185775 hasAuthorship W2923185775A5036347970 @default.
- W2923185775 hasAuthorship W2923185775A5039229244 @default.
- W2923185775 hasAuthorship W2923185775A5079071782 @default.
- W2923185775 hasAuthorship W2923185775A5079962049 @default.
- W2923185775 hasBestOaLocation W29231857751 @default.
- W2923185775 hasConcept C104317684 @default.
- W2923185775 hasConcept C137620995 @default.
- W2923185775 hasConcept C145059251 @default.
- W2923185775 hasConcept C165864922 @default.
- W2923185775 hasConcept C28328180 @default.
- W2923185775 hasConcept C54355233 @default.
- W2923185775 hasConcept C62478195 @default.
- W2923185775 hasConcept C86803240 @default.
- W2923185775 hasConcept C95444343 @default.
- W2923185775 hasConceptScore W2923185775C104317684 @default.
- W2923185775 hasConceptScore W2923185775C137620995 @default.
- W2923185775 hasConceptScore W2923185775C145059251 @default.
- W2923185775 hasConceptScore W2923185775C165864922 @default.
- W2923185775 hasConceptScore W2923185775C28328180 @default.
- W2923185775 hasConceptScore W2923185775C54355233 @default.
- W2923185775 hasConceptScore W2923185775C62478195 @default.
- W2923185775 hasConceptScore W2923185775C86803240 @default.
- W2923185775 hasConceptScore W2923185775C95444343 @default.