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• W2923324495 abstract "Peripheral nerve injuries often induce neuropathic pain through inflammation. Cryptotanshinone isolated from Salvia miltiorrhiza Bunge has been found to exert anti-inflammatory and analgesic activities. Thus, this study aimed to determine whether cryptotanshinone inhibits chronic constriction injury (CCI)-induced neuropathic pain in rats and its mechanism of action. CCI was performed by applying four loose ligatures to rat sciatic nerve. Cryptotanshinone was orally administered using pre-surgery, acute or repeated post-surgery treatment. The pain behaviors were determined by recording paw withdrawal mechanical threshold (PWMT) and thermal withdrawal latency (TWL). ELISA kits were used to measure interleukin (IL)-6, IL-1β and tumor necrosis factor (TNF)-α levels. qRT-PCR were performed to detect IL-6, IL-1β, TNF-α, PI3K and Akt expression. The phosphorylation of PI3K/Akt signaling was assessed using western blotting. PWMT and TWL in CCI group were higher than those in the control and sham groups. The acute post-CCI cryptotanshinone treatment but not pre-surgery treatment reduced PWMT and TWL. The effect of cryptotanshinone is more prominent when it was repeatedly administered after CCI. The CCI-induced increase in IL-6, IL-1β, TNF-α, PI3K/Akt signaling and their phosphorylation was also suppressed by repeated post-CCI cryptotanshinone treatment. This study suggested that post-CCI cryptotanshinone treatment reduced the surgery-induced neuropathic pain by suppressing PI3K/Akt signaling therefore inhibited inflammation." @default.
• W2923324495 created "2019-04-01" @default.
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• W2923324495 date "2019-05-01" @default.
• W2923324495 modified "2023-10-14" @default.
• W2923324495 title "Antinociceptive and anti-inflammatory effects of cryptotanshinone through PI3K/Akt signaling pathway in a rat model of neuropathic pain" @default.
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• W2923324495 doi "https://doi.org/10.1016/j.cbi.2019.03.016" @default.
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