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• W2923343054 abstract "ABSTRACT Objective To evaluate and compare the performance of routine ultrasonographic estimated fetal weight (EFW) and fetal abdominal circumference (AC) at 31 + 0 to 33 + 6 and 35 + 0 to 36 + 6 weeks' gestation in the prediction of a small‐for‐gestational‐age (SGA) neonate. Methods This was a prospective study of 21 989 singleton pregnancies undergoing routine ultrasound examination at 31 + 0 to 33 + 6 weeks' gestation and 45 847 undergoing routine ultrasound examination at 35 + 0 to 36 + 6 weeks' gestation. In each case, the estimated fetal weight (EFW) from measurements of fetal head circumference, AC and femur length was calculated using the Hadlock formula and expressed as a percentile according to The Fetal Medicine Foundation fetal and neonatal population weight charts. The same charts were used for defining a SGA neonate with birth weight < 10 th and < 3 rd percentiles. For each gestational‐age window, the screen‐positive and detection rates, at different EFW percentile cut‐offs between the 10 th and 50 th percentiles, were calculated for prediction of delivery of a SGA neonate with birth weight < 10 th and < 3 rd percentiles within 2 weeks and at any stage after assessment. The areas under the receiver–operating characteristics curves (AUC) in screening for a SGA neonate by EFW and AC at 31 + 0 to 33 + 6 and at 35 + 0 to 36 + 6 weeks' gestation were compared. Results First, the AUCs in screening by EFW for a SGA neonate with birth weight < 10 th and < 3 rd percentiles delivered within 2 weeks and at any stage after screening at 35 + 0 to 36 + 6 weeks' gestation were significantly higher than those at 31 + 0 to 33 + 6 weeks ( P < 0.001). Second, at both 35 + 0 to 36 + 6 and 31 + 0 to 33 + 6 weeks' gestation, the predictive performance for a SGA neonate with birth weight < 10 th and < 3 rd percentiles born at any stage after screening was significantly higher using EFW Z ‐score than AC Z ‐score. Similarly, at 35 + 0 to 36 + 6 weeks, but not at 31 + 0 to 33 + 6 weeks, the predictive performance for a SGA neonate with birth weight < 10 th and < 3 rd percentiles born within 2 weeks after screening was significantly higher using EFW Z ‐score than AC Z ‐score. Third, screening by EFW < 10 th percentile at 35 + 0 to 36 + 6 weeks' gestation predicted 70% and 84% of neonates with birth weight < 10 th and < 3 rd percentiles, respectively, born within 2 weeks after assessment, and the respective values for a neonate born at any stage after assessment were 46% and 65%. Fourth, prediction of > 85% of SGA neonates with birth weight < 10 th percentile born at any stage after screening at 35 + 0 to 36 + 6 weeks' gestation requires use of EFW < 40 th percentile. Screening at this percentile cut‐off predicted 95% and 99% of neonates with birth weight < 10 th and < 3 rd percentiles, respectively, born within 2 weeks after assessment, and the respective values for a neonate born at any stage after assessment were 87% and 94%. Conclusions The predictive performance for a SGA neonate of routine ultrasonographic examination during the third trimester is higher if, first, the scan is carried out at 35 + 0 to 36 + 6 weeks' gestation than at 31 + 0 to 33 + 6 weeks, second, the method of screening is EFW than fetal AC, third, the outcome measure is birth weight < 3 rd than < 10 th percentile, and, fourth, if delivery occurs within 2 weeks than at any stage after assessment. Prediction of a SGA neonate by EFW < 10 th percentile is modest and prediction of > 85% of cases at 35 + 0 to 36 + 6 weeks' gestation necessitates use of EFW < 40 th percentile. Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd." @default.
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• W2923343054 date "2019-04-30" @default.
• W2923343054 modified "2023-10-16" @default.
• W2923343054 title "Routine ultrasound at 32 <i>vs</i> 36 weeks' gestation: prediction of small‐for‐gestational‐age neonates" @default.
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• W2923343054 doi "https://doi.org/10.1002/uog.20258" @default.
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