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- W2923343391 abstract "The effect of breed on cruciate ligament rupture (CR) presentation suggests that genetic factors play a role in CR pathogenesis. Identification of valid genetic risk factors influencing CR may lead to the discovery of targets for medical intervention and aid in the development of a predictive genetic test for the condition. The genetic factors that influence complex traits are typically composed of many small-effect mutations and fewer large-effect mutations that contribute predominantly additively to phenotypic variation. Complete discovery of genetic variants contributing to CR will likely require a combination of complementary analyses including candidate gene analyses, large-scale genome-wide association studies (GWAS), and next-generation sequencing. The young (human) female athlete is another cohort that shares characteristics of the CR phenotype found in dogs. The overlap between the results of canine, equine, and human discovery research implicating ACAN (aggrecan) in susceptibility to anterior cruciate ligament (ACL) rupture makes ACAN a particularly interesting target for further genetic investigation." @default.
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- W2923343391 date "2017-01-17" @default.
- W2923343391 modified "2023-09-27" @default.
- W2923343391 title "Genetics of Cruciate Ligament Rupture" @default.
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- W2923343391 doi "https://doi.org/10.1002/9781119261728.ch7" @default.
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